{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:47:07Z","timestamp":1783154827618,"version":"3.54.6"},"reference-count":31,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Invasive aspergillosis and other invasive fungal infections are associated with significant morbidity and mortality in immunocompromised patients, in large part due to limitations of existing diagnostic methods for these infections. Detection of species-specific volatile sesquiterpene metabolites of fungal origin in the breath of patients with invasive fungal infections allows the diagnosis and monitoring of these infections\n                    <jats:italic>in vivo<\/jats:italic>\n                    , non-invasively and more rapidly than possible with current diagnostic methods. While detection of exogenous microbial volatile metabolites in the breath has opened up a new and exciting dimension of diagnostic research and development in infectious diseases, we discuss the daunting challenges to volatile diagnostic biomarker discovery and clinical development.\n                  <\/jats:p>","DOI":"10.1088\/1752-7163\/aa98a1","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T04:15:21Z","timestamp":1510028121000},"page":"027108","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Breath-based diagnosis of fungal infections"],"prefix":"10.1088","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2228-1507","authenticated-orcid":false,"given":"Mahesh J Thalavitiya","family":"Acharige","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Brigham and Women\u2019s Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115,"},{"name":"Harvard Medical School, 25 Shattuck St., Boston, MA 02115,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seena","family":"Koshy","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Brigham and Women\u2019s Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115,"},{"name":"Harvard Medical School, 25 Shattuck St., Boston, MA 02115,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Ismail","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Brigham and Women\u2019s Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115,"},{"name":"Harvard Medical School, 25 Shattuck St., Boston, MA 02115,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obadah","family":"Aloum","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Brigham and Women\u2019s Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115,"},{"name":"Harvard Medical School, 25 Shattuck St., Boston, MA 02115,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majd","family":"Jazaerly","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Brigham and Women\u2019s Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115,"},{"name":"Harvard Medical School, 25 Shattuck St., Boston, MA 02115,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Leon","family":"Astudillo","sequence":"additional","affiliation":[{"name":"Harvard Medical School, 25 Shattuck St., Boston, MA 02115,"},{"name":"Division of Respiratory Diseases, Boston Children\u2019s Hospital, 300 Longwood Ave., Boston, MA 02115,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Koo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Brigham and Women\u2019s Hospital, 181 Longwood Avenue, MCP642, Boston, MA 02115,"},{"name":"Harvard Medical School, 25 Shattuck St., Boston, MA 02115,"},{"name":"Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"jbraa98a1bib1","doi-asserted-by":"publisher","first-page":"8230","DOI":"10.3390\/s91008230","type":"journal-article","article-title":"Breath analysis using laser spectroscopic techniques: breath biomarkers, spectral fingerprints, and detection limits","volume":"9","author":"Wang","year":"2009","journal-title":"Sensors"},{"key":"jbraa98a1bib2","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1007\/s13361-016-1533-7","type":"journal-article","article-title":"Real-time quantitative analysis of valproic acid in exhaled breath by low temperature plasma ionization mass spectrometry","volume":"28","author":"Gong","year":"2016","journal-title":"J. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2017-08-29","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-11-07","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-02-06","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}