{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:47:42Z","timestamp":1788306462265,"version":"build-2803163510"},"reference-count":51,"publisher":"IOP Publishing","issue":"3","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objectives<\/jats:italic>\n                    : Prolonged suppression of gastric acid secretion by proton pump inhibitors (PPIs) may alter the bacterial microbiota of the upper gastrointestinal tract and lead to small bowel bacterial overgrowth (SBBO). Published reports have shown conflicting results on the association between PPI therapy and risk of SBBO development. We evaluated whether long-term PPI treatment is associated with presence of SBBO as determined by breath hydrogen (H\n                    <jats:sub>2<\/jats:sub>\n                    ) and methane (CH\n                    <jats:sub>4<\/jats:sub>\n                    ) excretion. We also assessed the differences in H\n                    <jats:sub>2<\/jats:sub>\n                    \/CH\n                    <jats:sub>4<\/jats:sub>\n                    excretion patterns in patients taking PPI compared with those not taking the medication and searched for the potential predictors of a positive breath test result.\n                    <jats:italic>Material and methods<\/jats:italic>\n                    : This was a prospective cohort study that included 67 PPI-treated patients (PPIT) and 62 not-receiving PPI (C, comparison). PPIT and C underwent a glucose H\n                    <jats:sub>2<\/jats:sub>\n                    \/CH\n                    <jats:sub>4<\/jats:sub>\n                    breath test (HMBT) to determine the presence of SBBO.\n                    <jats:italic>Results<\/jats:italic>\n                    : The prevalence of SBBO was significantly higher in PPIT compared to C (44.8% versus 21%, p\u00a0=\u00a00.005, OR\u00a0=\u00a03.06, 95% CI 1.40\u20136.66) as determined by H\n                    <jats:sub>2<\/jats:sub>\n                    and CH\n                    <jats:sub>4<\/jats:sub>\n                    excretion. We found that PPIT had all H\n                    <jats:sub>2<\/jats:sub>\n                    test parameters (baseline H\n                    <jats:sub>2<\/jats:sub>\n                    levels, maximum peak of H\n                    <jats:sub>2<\/jats:sub>\n                    as well as mean H\n                    <jats:sub>2<\/jats:sub>\n                    through the whole test) significantly higher than C. Even those PPIT who did not meet the criteria of breath test positivity had statistically higher breath H\n                    <jats:sub>2<\/jats:sub>\n                    levels compared to C. Although we did not observe significant differences in CH\n                    <jats:sub>4<\/jats:sub>\n                    excretion between groups, 19.4% of PPIT and 12.9% of C would have had a false-negative HMBT results had CH\n                    <jats:sub>4<\/jats:sub>\n                    not been taken into account.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : Long-term PPI use was found to be significantly associated with SBBO development as determined by breath H\n                    <jats:sub>2<\/jats:sub>\n                    and CH\n                    <jats:sub>4<\/jats:sub>\n                    excretion. CH\n                    <jats:sub>4<\/jats:sub>\n                    determination reduces the number of falsely negative test results.\n                  <\/jats:p>","DOI":"10.1088\/1752-7163\/aa9dcf","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T09:15:13Z","timestamp":1511860513000},"page":"036006","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Long-term proton pump inhibitor therapy leads to small bowel bacterial overgrowth as determined by breath hydrogen and methane excretion"],"prefix":"10.1088","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6109-2226","authenticated-orcid":false,"given":"Agnieszka","family":"Sieczkowska","sequence":"first","affiliation":[{"name":"Medical University of Gdansk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Landowski","sequence":"additional","affiliation":[{"name":"Medical University of Gdansk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Gibas","sequence":"additional","affiliation":[{"name":"Medical University of Gdansk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Kami\u0144ska","sequence":"additional","affiliation":[{"name":"Medical University of Gdansk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Lifschitz","sequence":"additional","affiliation":[{"name":"Section of Pediatric Gastroenterology, Hepatology and Transplantation, Hospital Italiano, Buenos Aires,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,3,12]]},"reference":[{"key":"jbraa9dcfbib1","type":"journal-article","volume":"36","author":"The Dutch Foundation for Pharmaceutical Statistics (SFK)","year":"2014","journal-title":"Facts and figures"},{"key":"jbraa9dcfbib2","doi-asserted-by":"publisher","first-page":"649","DOI":"10.17235\/reed.2015.4022\/2015","type":"journal-article","article-title":"PPIs: between overuse and underprescription when really necessary 2015","volume":"107","author":"Mart\u00edn de Argila de Prados","year":"2015","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"jbraa9dcfbib3","article-title":"100 Best-Selling, Most Prescribed Branded Drugs Through March","author":"Troy Brown","year":"2015","type":"other"},{"key":"jbraa9dcfbib4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/ajhp\/56.suppl_4.S11","type":"journal-article","article-title":"Safety profile of the proton pump inhibitors","volume":"56","author":"Relly","year":"1999","journal-title":"Am. J. Health. Syst. Pharm."},{"key":"jbraa9dcfbib5","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1097\/MEG.0b013e3282f52f95","type":"journal-article","article-title":"Inappropriate prescription of proton pump inhibitors on two pulmonary medicine wards","volume":"20","author":"van Vliet","year":"2008","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"jbraa9dcfbib6","doi-asserted-by":"publisher","first-page":"288","DOI":"10.2174\/157488410793352067","type":"journal-article","article-title":"Overuse of PPIs in patients at admission, during treatment, and at discharge in a tertiary Spanish hospital","volume":"5","author":"Ramirez","year":"2010","journal-title":"Curr. Clin. Pharmacol."},{"key":"jbraa9dcfbib7","first-page":"44","type":"journal-article","article-title":"Frequency of proton pump inhibitor prescription based in clinical practice guidelines in hospitalized patients in two academic hospitals in Lima Peru","volume":"32","author":"Bustamante Robles","year":"2012","journal-title":"Rev. Gastroenterol. Peru."},{"key":"jbraa9dcfbib8","first-page":"51","author":"Use and Appropriateness Study Mauriziano Hospital Group","year":"2015","type":"book"},{"key":"jbraa9dcfbib9","doi-asserted-by":"publisher","first-page":"e817","DOI":"10.1542\/peds.2005-1655","type":"journal-article","article-title":"Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children","volume":"116","author":"Working Group on Intestinal Infections of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP)","year":"2006","journal-title":"Pediatrics"},{"key":"jbraa9dcfbib10","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1503\/cmaj.071330","type":"journal-article","article-title":"Use of proton pump inhibitors and risk of osteoporosis-related fractures","volume":"179","author":"Targownik","year":"2008","journal-title":"CMAJ"},{"key":"jbraa9dcfbib11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2807\/1560-7917.ES2014.19.32.20873","type":"journal-article","article-title":"Potential association between the recent increase in campylobacteriosis incidence in the Netherlands and proton-pump inhibitor use\u2014an ecological study","volume":"19","author":"Bouwknegt","year":"2014","journal-title":"Eurosurv."},{"key":"jbraa9dcfbib12","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1111\/j.1572-0241.2007.01275.x","type":"journal-article","article-title":"Systemic review of the risk of enteric infection in patients taking acid suppression","volume":"102","author":"Leonard","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"jbraa9dcfbib13","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/ajg.2012.179","type":"journal-article","article-title":"Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis","volume":"107","author":"Janarthanan","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"jbraa9dcfbib14","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1001\/jamainternmed.2015.42","type":"journal-article","article-title":"Continuous proton pump inhibitor therapy and the associated risk of recurrent Clostridium difficile infection","volume":"175","author":"McDonald","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"jbraa9dcfbib15","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1111\/j.1365-2036.2011.04874.x","type":"journal-article","article-title":"Systemic review: the use of proton pump inhibitors and increased susceptibility to enteric infection","volume":"34","author":"Bavishi","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"jbraa9dcfbib16","first-page":"30","type":"journal-article","article-title":"Diagnosis of small intestinal bacterial overgrowth in the clinical practice","volume":"17","author":"Gabrielli","year":"2013","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"jbraa9dcfbib17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2036.2009.03951.x","type":"journal-article","article-title":"Methodology and indications of H2-breath testing in gastrointestinal diseases: the Rome Consensus Conference","volume":"29","author":"Bonazzi","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"jbraa9dcfbib18","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/7\/2\/024001","type":"journal-article","article-title":"The importance of methane breath testing: a review","volume":"7","author":"de Lacy Costello","year":"2013","journal-title":"J. Breath Res."},{"key":"jbraa9dcfbib19","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1007\/s10620-009-1012-0","type":"journal-article","article-title":"Methane and the gastrointestinal tract 2010","volume":"55","author":"Sahakian","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"jbraa9dcfbib20","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1136\/gut.26.1.69","type":"journal-article","article-title":"Methane excretion in man\u2014a study of breath, flatus and faeces","volume":"26","author":"McKay","year":"1985","journal-title":"Gut"},{"key":"jbraa9dcfbib21","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1136\/gut.31.3.300","type":"journal-article","article-title":"Breath hydrogen response to lactulose in healthy subjects: relationship to methane producing status","volume":"31","author":"Cloarac","year":"1990","journal-title":"Gut"},{"key":"jbraa9dcfbib22","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/ajg.2012.4","type":"journal-article","article-title":"Proton pump inhibitor therapy use does not predispose to small bowel bacterial overgrowth","volume":"107","author":"Ratuapli","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"jbraa9dcfbib23","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1007\/s10620-009-1010-2","type":"journal-article","article-title":"Proton Pump Inhibitor therapy does not affect Hydrogen production on lactulose breath test in subjects with IBS","volume":"55","author":"Law","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"jbraa9dcfbib24","first-page":"197","type":"journal-article","article-title":"Effect of the proton pump inhibitor on breath hydrogen and methane concentrations","volume":"22","author":"Ohbayashi","year":"1999","journal-title":"Teikyo Med. J."},{"key":"jbraa9dcfbib25","first-page":"268","type":"journal-article","article-title":"Association between chronic use of proton pump inhibitors and small- intestinal bacterial overgrowth assessed using lactulose hydrogen breath tests","volume":"62","author":"Fujiwara","year":"2015","journal-title":"Hepatogastroenterology"},{"key":"jbraa9dcfbib26","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.clinbiochem.2016.08.017","type":"journal-article","article-title":"Functional 13C-urea and glucose hydrogen\/methane breath tests reveal significant association of small intestinal bacterial overgrowth in individuals with active Helicobacter pylori infection","volume":"50","author":"Enko","year":"2017","journal-title":"Clin. Biochem"},{"key":"jbraa9dcfbib27","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/ajg.2017.46","type":"journal-article","article-title":"Hydrogen and methane-based breath testing in gastrointestinal disorders: The North American consensus","volume":"112","author":"Rezaie","year":"2017","journal-title":"Am J Gastroenterol."},{"key":"jbraa9dcfbib28","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1159\/000336174","type":"journal-article","article-title":"Comparison of lactulose and glucose breath test for diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome","volume":"85","author":"Rana","year":"2012","journal-title":"Digestion"},{"key":"jbraa9dcfbib29","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1136\/gut.35.1.23","type":"journal-article","article-title":"Duodenal bacterial overgrowth during treatment in outpatients with omeprazole","volume":"35","author":"Fried","year":"1994","journal-title":"Gut"},{"key":"jbraa9dcfbib30","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.cgh.2009.12.022","type":"journal-article","article-title":"Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy","volume":"8","author":"Lombardo","year":"2010","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"jbraa9dcfbib31","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/j.1365-2362.2010.02419.x","type":"journal-article","article-title":"Effects of long-term PPI treatment on producing bowel symptoms and SIBO","volume":"41","author":"Compare","year":"2011","journal-title":"Eur. J. Clin. Invest."},{"key":"jbraa9dcfbib32","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1111\/apt.12304","type":"journal-article","article-title":"Dysmotility and proton pump inhibitor use are independent risk factors for small intestinal bacterial and\/or fungal overgrowth","volume":"37","author":"Jacobs","year":"2013","journal-title":"Aliment. Pharmacol. Ther."},{"key":"jbraa9dcfbib33","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1097\/MCG.0b013e318267b55d","type":"journal-article","article-title":"The innovative potential of Lactobacillus rhamnosus LR06, Lactobacillus pentosus LPS01, Lactobacillus plantarum LP01, and Lactobacillus delbrueckii Subsp. delbrueckii LDD01 to restore the \u2018gastric barrier effect\u2019 in patients chronically treated with PPI: a pilot study","volume":"46","author":"Del Piano","year":"2012","journal-title":"J. Clin. Gastroenterol."},{"key":"jbraa9dcfbib34","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.jped.2012.12.005","type":"journal-article","article-title":"A double-blind placebo-controlled randomized trial on probiotics in small bowel bacterial overgrowth in children treated with omeprazole","volume":"89","author":"Hegar","year":"2013","journal-title":"J. Pediatr. (Rio J)"},{"key":"jbraa9dcfbib35","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1001\/jamapediatrics.2014.696","type":"journal-article","article-title":"Changes in gastric and lung microflora with acid suppression: acid suppression and bacterial growth","volume":"168","author":"Rosen","year":"2014","journal-title":"JAMA Pediatr."},{"key":"jbraa9dcfbib36","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/j.jpeds.2015.01.004","type":"journal-article","article-title":"Small bowel bacterial overgrowth associated with persistence of abdominal symptoms in children treated with a proton pump inhibitor","volume":"166","author":"Sieczkowska","year":"2015","journal-title":"J. Pediatr."},{"key":"jbraa9dcfbib37","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1097\/MEG.0000000000000815","type":"journal-article","article-title":"Short article: risk of small intestinal bacterial overgrowth with chronic use of proton pump inhibitors in children","volume":"29","author":"Cares","year":"2017","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"jbraa9dcfbib38","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1136\/gut.39.1.54","type":"journal-article","article-title":"Bacterial overgrowth during treatment with omeprazole compared with cimetidine: a prospective randomised double blind study","volume":"39","author":"Thorens","year":"1996","journal-title":"Gut"},{"key":"jbraa9dcfbib39","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1046\/j.1365-2036.1996.d01-506.x","type":"journal-article","article-title":"Altered bowel function and duodenal bacterial overgrowth in patients treated with omeprazole","volume":"10","author":"Lewis","year":"1996","journal-title":"Aliment. Pharmacol. Ther."},{"key":"jbraa9dcfbib40","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1046\/j.1365-2036.1998.00275.x","type":"journal-article","article-title":"Drug-induced hypochlorhydria causes high duodenal bacterial counts in the elderly","volume":"12","author":"Pereira","year":"1998","journal-title":"Aliment. Pharmacol. Ther."},{"key":"jbraa9dcfbib41","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1111\/j.1365-2036.2011.04625.x","type":"journal-article","article-title":"Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture","volume":"33","author":"Choung","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"jbraa9dcfbib42","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/ageing\/26.2.87","type":"journal-article","article-title":"The effect of long-term omeprazole on the glucose-hydrogen breath test in elderly patients","volume":"26","author":"Hutchinson","year":"1997","journal-title":"Age Ageing"},{"key":"jbraa9dcfbib43","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12876-016-0484-6","type":"journal-article","article-title":"Small intestinal bacterial overgrowth is associated with irritable bowel syndrome and is independent of proton pump inhibitor usage","volume":"16","author":"Giamarellos-Bourboulis","year":"2016","journal-title":"BMC Gastroenterol."},{"key":"jbraa9dcfbib44","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1038\/ajg.2012.257","type":"journal-article","article-title":"PPI Use and SIBO: predisposition or cause?","volume":"10","author":"Lombardo","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"jbraa9dcfbib45","doi-asserted-by":"publisher","first-page":"5932","DOI":"10.3748\/wjg.v18.i41.5932","type":"journal-article","article-title":"Methane production and small intestinal bacterial overgrowth in children living in a slum","volume":"18","author":"Mello","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"jbraa9dcfbib46","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1084\/jem.133.3.572","type":"journal-article","article-title":"Factors influencing pulmonary methane excretion in man. An indirect method of studying the in situ metabolism of the methane-producing colonic bacteria","volume":"133","author":"Bond","year":"1971","journal-title":"J. Exp. Med."},{"key":"jbraa9dcfbib47","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1023\/A:1021738515885","type":"journal-article","article-title":"Methane production during lactulose breath test is associated with gastrointestinal disease presentation","volume":"48","author":"Pimentel","year":"2003","journal-title":"Dig. Dis. Sci."},{"key":"jbraa9dcfbib48","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1007\/s10620-010-1276-4","type":"journal-article","article-title":"Abnormal breath testing in IBS: a meta-analysis","volume":"55","author":"Shah","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"jbraa9dcfbib49","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1097\/00005176-198508000-00013","type":"journal-article","article-title":"The development of methane production in childhood and adolescence","volume":"4","author":"Peled","year":"1985","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"jbraa9dcfbib50","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.cgh.2012.12.011","type":"journal-article","article-title":"Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: a meta-analysis","volume":"11","author":"Lo","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol"},{"key":"jbraa9dcfbib51","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s00535-017-1371-9","type":"journal-article","article-title":"Meta-analysis: proton pump inhibitors moderately increase the risk of small intestinal bacterial overgrowth","volume":"53","author":"Su","year":"2017","journal-title":"J Gastroenterol."}],"container-title":["Journal of Breath Research"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aa9dcf","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aa9dcf\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aa9dcf\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aa9dcf","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aa9dcf","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aa9dcf\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aa9dcf\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aa9dcf\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aa9dcf\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aa9dcf\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aa9dcf","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aa9dcf\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:03:32Z","timestamp":1783166612000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aa9dcf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,12]]},"references-count":51,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,12]]},"published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1752-7163\/aa9dcf","relation":{},"ISSN":["1752-7155","1752-7163"],"issn-type":[{"value":"1752-7155","type":"print"},{"value":"1752-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,12]]},"assertion":[{"value":"Long-term proton pump inhibitor therapy leads to small bowel bacterial overgrowth as determined by breath hydrogen and methane excretion","name":"article_title","label":"Article Title"},{"value":"Journal of Breath Research","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2018 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2017-10-28","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-11-28","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-03-12","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}