{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:08:49Z","timestamp":1787008129729,"version":"build-2736575974"},"reference-count":29,"publisher":"IOP Publishing","issue":"3","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The microparticle fraction of exhaled breath is of interest for developing clinical biomarkers. Exhaled particles may contain non-volatile components from all parts of the airway system, formed during normal breathing. This study aimed to evaluate a new, simple sampling device, based on impaction, for collecting microparticles from exhaled breath. Performance of the new device was compared with that of the existing SensAbues membrane filter device. The analytical work used liquid chromatography-tandem mass spectrometry methods. The new device collected three subsamples and these were separately analysed from eight individuals. No difference was observed between the centre position (0.91 ng\/sample) and the side positions (1.01 ng\/sample) using major phosphatidylcholine (PC) 16:0\/16:0 as the analyte. Exhaled breath was collected from eight patients on methadone maintenance treatment. The intra-individual variability in measured methadone concentration between the three collectors was 8.7%. In another experiment using patients on methadone maintenance treatment, the sampling efficiency was compared with an established filter device. Compared to the existing device, the efficiency of the new device was 121% greater for methadone and 1450% greater for DPPC. The data from lipid analysis also indicated that a larger fraction of the collected material was from the distal parts. Finally, a study using an optical particle counter indicated that the device preferentially collects the larger particle fraction. In conclusion, this study demonstrates the usefulness of the new device for collecting non-volatile components from exhaled breath. The performance of the device was superior to the filter device in several aspects.<\/jats:p>","DOI":"10.1088\/1752-7163\/aaaf24","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T04:45:10Z","timestamp":1518583510000},"page":"036005","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Evaluation of a new simple collection device for sampling of microparticles in exhaled breath"],"prefix":"10.1088","volume":"12","author":[{"given":"Sabina","family":"Seferaj","sequence":"first","affiliation":[{"name":"Karolinska University Laboratory"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Ullah","sequence":"additional","affiliation":[{"name":"Karolinska University Laboratory"},{"name":"Karolinska Institutet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Tinglev","sequence":"additional","affiliation":[{"name":"Karolinska Institutet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sten","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Dependence Clinic V\u00e4stmanland, V\u00e4ster\u00e5s,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Winberg","sequence":"additional","affiliation":[{"name":"Munkplast AB, Uppsala,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stambeck","sequence":"additional","affiliation":[{"name":"Munkplast AB, Uppsala,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3546-8872","authenticated-orcid":false,"given":"Olof","family":"Beck","sequence":"additional","affiliation":[{"name":"Karolinska University Laboratory"},{"name":"Karolinska Institutet"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,3,12]]},"reference":[{"key":"jbraaaf24bib1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1373\/clinchem.2015.239285","type":"journal-article","article-title":"Potential of mass spectrometry in developing clinical laboratory biomarkers of nonvolatiles in exhaled breath","volume":"62","author":"Beck","year":"2016","journal-title":"Clin. Chem."},{"key":"jbraaaf24bib2","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.1007\/s00204-016-1817-5","type":"journal-article","article-title":"Breath biomarkers in toxicology","volume":"90","author":"Pleil","year":"2016","journal-title":"Arch. Toxicol."},{"key":"jbraaaf24bib3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150481","type":"journal-article","article-title":"Collecting protein biomarkers in breath using electret filters: a preliminary method on new technical model and human study","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"key":"jbraaaf24bib4","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1373\/clinchem.2011.169235","type":"journal-article","article-title":"Exhaled endogenous particles contain lung proteins","volume":"58","author":"Bredberg","year":"2012","journal-title":"Clin. Chem."},{"key":"jbraaaf24bib5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1183\/09031936.00195610","type":"journal-article","article-title":"TOF-SIMS analysis of exhaled particles from patients with asthma and healthy controls","volume":"39","author":"Almstrand","year":"2012","journal-title":"Eur. Respir. J."},{"key":"jbraaaf24bib6","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1089\/jamp.2009.0809","type":"journal-article","article-title":"Characterization of exhaled particles from the healthy human lung\u2014a systematic analysis in relation to pulmonary function variables","volume":"23","author":"Schwarz","year":"2010","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"key":"jbraaaf24bib7","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1089\/jamp.2016.1330","type":"journal-article","article-title":"Exhaled particles after a standardized breathing maneuver","volume":"30","author":"Bake","year":"2017","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"key":"jbraaaf24bib8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aca.2013.07.049","type":"journal-article","article-title":"Exhaled breath condensate: determination of non-volatile compounds and their potential for clinical diagnosis and monitoring","volume":"805","author":"Kuban","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"jbraaaf24bib9","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1089\/jam.1997.10.105","type":"journal-article","article-title":"The size distribution of droplets in the exhaled breath of healthy human subjects","volume":"10","author":"Papineni","year":"1997","journal-title":"J. Aerosol Med."},{"key":"jbraaaf24bib10","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1089\/jamp.2013.1104","type":"journal-article","article-title":"Characterization of exhaled particles from the human lungs in airway obstruction","volume":"28","author":"Schwarz","year":"2015","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"key":"jbraaaf24bib11","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1021\/ac802055k","type":"journal-article","article-title":"Airway monitoring by collection and mass spectrometric analysis of exhaled particles","volume":"81","author":"Almstrand","year":"2009","journal-title":"Anal. Chem."},{"key":"jbraaaf24bib12","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/10\/2\/026001","type":"journal-article","article-title":"Characterization of exhaled breath particles collected by an electret filter technique","volume":"10","author":"Tinglev","year":"2016","journal-title":"J. Breath Res."},{"key":"jbraaaf24bib13","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/7\/2\/026006","type":"journal-article","article-title":"Detection of drugs of abuse in exhaled breath using a device for rapid collection: comparison with plasma, urine and self-reporting in 47 drug users","volume":"7","author":"Beck","year":"2013","journal-title":"J. Breath Res."},{"key":"jbraaaf24bib14","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7163\/aa8b25","type":"journal-article","article-title":"Two techniques to sample non-volatiles in breath\u2014exemplified by methadone","volume":"12","author":"Ljungkvist","year":"2017","journal-title":"J. Breath Res."},{"key":"jbraaaf24bib15","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1373\/clinchem.2013.207407","type":"journal-article","article-title":"Cannabinoids in exhaled breath following controlled administration of smoked cannabis","volume":"59","author":"Himes","year":"2013","journal-title":"Clin. Chem."},{"key":"jbraaaf24bib16","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.bcp.2015.09.008","type":"journal-article","article-title":"First report on the pharmacokinetics of tramadol and O-desmethyltramadol in exhaled breath compared to plasma and oral fluid after a single oral dose","volume":"98","author":"Meyer","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"jbraaaf24bib17","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0009-9120(83)90070-X","type":"journal-article","article-title":"The detection of delta-9-tetrahydrocannabinol in the breath of human subjects","volume":"16","author":"Manolis","year":"1983","journal-title":"Clin. Biochem."},{"key":"jbraaaf24bib18","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/jat\/34.5.233","type":"journal-article","article-title":"Amphetamines detected in exhaled breath from drug addicts: a new possible method for drugs-of-abuse testing","volume":"34","author":"Beck","year":"2010","journal-title":"J. Anal. Toxicol."},{"key":"jbraaaf24bib19","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.jchromb.2010.06.035","type":"journal-article","article-title":"Method for determination of methadone in exhaled breath collected from subjects undergoing methadone maintenance treatment","volume":"878","author":"Beck","year":"2010","journal-title":"J. Chromatogr. B"},{"key":"jbraaaf24bib20","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1093\/anatox\/35.8.541","type":"journal-article","article-title":"Detection of \u03949-tetrahydrocannabinol in exhaled breath collected from cannabis users","volume":"35","author":"Beck","year":"2011","journal-title":"J. Anal Toxicol."},{"key":"jbraaaf24bib21","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.clinbiochem.2016.06.003","type":"journal-article","article-title":"\u0394(9)-Tetrahydrocannabinol concentrations in exhaled breath and physiological effects following cannabis intake\u2014a pilot study using illicit cannabis","volume":"49","author":"Coucke","year":"2016","journal-title":"Clin. Biochem."},{"key":"jbraaaf24bib22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/FTD.0000000000000228","type":"journal-article","article-title":"Testing for drugs in exhaled breath collected with exabreath in a drug dependence population: comparison with data obtained in urine after liquid chromatographic-tandem mass spectrometric analyses","volume":"38","author":"Kintz","year":"2016","journal-title":"Ther. Drug Monit."},{"key":"jbraaaf24bib23","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1002\/rcm.7903","type":"journal-article","article-title":"Expanding analytical options in sports drug testing: mass spectrometric detection of prohibited substances in exhaled breath","volume":"31","author":"Thevis","year":"2017","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"jbraaaf24bib24","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jpba.2017.10.003","type":"journal-article","article-title":"A liquid chromatography and tandem mass spectrometry method to determine 28 non-volatile drugs of abuse in exhaled breath","volume":"148","author":"Ullah","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"jbraaaf24bib25","doi-asserted-by":"publisher","first-page":"11553","DOI":"10.1021\/acs.analchem.5b03433","type":"journal-article","article-title":"Measurement of lung phosphatidylcholines in exhaled breath particles by a convenient collection procedure","volume":"87","author":"Ullah","year":"2015","journal-title":"Anal. Chem."},{"key":"jbraaaf24bib26","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1002\/mas.21393","type":"journal-article","article-title":"Real-time monitoring of exhaled drugs by mass spectrometry","volume":"33","author":"Berchtold","year":"2014","journal-title":"Mass Spectrom. Rev."},{"key":"jbraaaf24bib27","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1021\/ac020361s","type":"journal-article","article-title":"Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS\/MS","volume":"75","author":"Matuszewski","year":"2003","journal-title":"Anal. Chem."},{"key":"jbraaaf24bib28","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1471-2466-14-10","type":"journal-article","article-title":"Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers","volume":"14","author":"Dushianthan","year":"2014","journal-title":"BMC Pulm. Med."},{"key":"jbraaaf24bib29","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S1095-6433(01)00306-3","type":"journal-article","article-title":"A comparison of the molecular species compositions of mammalian lung surfactant phospholipids","volume":"129","author":"Postle","year":"2001","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."}],"container-title":["Journal of Breath Research"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aaaf24","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aaaf24\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aaaf24\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aaaf24","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aaaf24","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aaaf24\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aaaf24\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aaaf24\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aaaf24\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aaaf24\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aaaf24","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aaaf24\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T12:33:22Z","timestamp":1779539602000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aaaf24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,12]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,12]]},"published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1752-7163\/aaaf24","relation":{},"ISSN":["1752-7155","1752-7163"],"issn-type":[{"value":"1752-7155","type":"print"},{"value":"1752-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,12]]},"assertion":[{"value":"Evaluation of a new simple collection device for sampling of microparticles in exhaled breath","name":"article_title","label":"Article Title"},{"value":"Journal of Breath Research","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2018 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2017-12-02","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-02-14","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-03-12","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}