{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T13:06:52Z","timestamp":1779541612305,"version":"3.53.1"},"reference-count":37,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Background &amp; Aims.<\/jats:italic>\n                    Increased nitric oxide is involved in abnormal hemodynamic parameters and respiratory function of cirrhotic patients. We aimed to quantify partitioning exhaled nitric oxide measurements in exhaled air in liver transplantation (LT) candidates and evaluate their relationships with chronotropic incompetence and aerobic capacity.\n                    <jats:italic>Methods.<\/jats:italic>\n                    We compared exhaled nitric oxide (NO) measurements, heart rate response and peak oxygen uptake during incremental exercise in liver transplantation candidates to those of controls.\n                    <jats:italic>Results.<\/jats:italic>\n                    As opposed to healthy control subjects, LT candidates displayed elevated alveolar NO, blunted chronotropic response and reduced\n                    <jats:italic>V<\/jats:italic>\n                    \u2032O\n                    <jats:sub>2<\/jats:sub>\n                    at maximal exercise. In LT candidates, median peak\n                    <jats:italic>V<\/jats:italic>\n                    \u2032O\n                    <jats:sub>2<\/jats:sub>\n                    was 18.7 ml kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    (interquartile range (IQR) 16.2; 21.8), corresponding to 65% (IQR 57; 72) of the predicted value. Compared with controls, LT candidates had increased levels of alveolar NO (median (IQR) 2.0 (1.2; 2.2) versus 3.1 (2.3; 4.5), p\u00a0&lt;\u00a00.001). In controls, no relations were found between alveolar NO and\n                    <jats:italic>V<\/jats:italic>\n                    \u2032O\n                    <jats:sub>2<\/jats:sub>\n                    peak or heart rate reserve whereas in cirrhotic patients, negative correlations and negative slopes were found between alveolar NO and\n                    <jats:italic>V<\/jats:italic>\n                    \u2032O\n                    <jats:sub>2<\/jats:sub>\n                    peak and heart rate reserve decrease.\n                    <jats:italic>Conclusions.<\/jats:italic>\n                    Increasing alveolar NO could be a specific pathophysiological condition limiting aerobic capacity in LT candidates.\n                  <\/jats:p>","DOI":"10.1088\/1752-7163\/aad847","type":"journal-article","created":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T09:45:27Z","timestamp":1533548727000},"page":"046008","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Elevated alveolar nitric oxide is linked to poor aerobic capacity and chronotropic incompetence in liver transplant candidates"],"prefix":"10.1088","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-9974","authenticated-orcid":false,"given":"S","family":"Hulo","sequence":"first","affiliation":[{"name":"Service d\u2019Explorations Fonctionnelles Respiratoires, H\u00f4pital Calmette, CHU Lille, F-59000,"},{"name":"Univ. Lille IMPECS IMPact de l\u2019Environnement Chimique sur la Sant\u00e9 humaine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J L","family":"Edme","sequence":"additional","affiliation":[{"name":"Service d\u2019Explorations Fonctionnelles Respiratoires, H\u00f4pital Calmette, CHU Lille, F-59000,"},{"name":"Univ. Lille IMPECS IMPact de l\u2019Environnement Chimique sur la Sant\u00e9 humaine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Inamo","sequence":"additional","affiliation":[{"name":"Martinique\u2014Facult\u00e9 de M\u00e9decine\u2014Universit\u00e9 des Antilles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Van Bulck","sequence":"additional","affiliation":[{"name":"Service d\u2019Explorations Fonctionnelles Respiratoires, H\u00f4pital Calmette, CHU Lille, F-59000,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Dharancy","sequence":"additional","affiliation":[{"name":"Service des Maladies de l\u2019Appareil Digestif et de la Nutrition, H\u00f4pital Huriez CHU Lille, F-59000,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Neviere","sequence":"additional","affiliation":[{"name":"Service d\u2019Explorations Fonctionnelles Respiratoires, H\u00f4pital Calmette, CHU Lille, F-59000,"},{"name":"Martinique\u2014Facult\u00e9 de M\u00e9decine\u2014Universit\u00e9 des Antilles"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,8,21]]},"reference":[{"key":"jbraad847bib1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1002\/lt.22472","type":"journal-article","article-title":"Exercise capacity and muscle strength in patients with cirrhosis","volume":"18","author":"Jones","year":"2012","journal-title":"Liver Transplant Off. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2017-09-15","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-08-06","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-08-21","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}