{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T08:36:53Z","timestamp":1794645413707,"version":"4.9.1"},"reference-count":47,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81800967"],"award-info":[{"award-number":["81800967"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:italic>Aim<\/jats:italic>: This study aims to assess the microbiome variations related to intraoral halitosis and its relationship with volatile sulfur compounds (VSCs) among periodontally healthy Chinese adults. <jats:italic>Material and methods<\/jats:italic>: Tongue coating samples were collected from 28 periodontally healthy subjects (16 subjects with halitosis and 12 subjects without halitosis) who fulfilled the selection criteria. The organoleptic score (OS) was used to evaluate the halitosis status. The characterization of associated microbial communities was performed using 16S rRNA gene pyrosequencing and metagenomics methods. <jats:italic>Results<\/jats:italic>: A wide range of microbial communities, including 13 phyla, 23 classes, 37 orders, 134 genera, 266 species and 349 operational taxonomic units (OTUs), were detected. The Shannon index values were significantly higher in the halitosis group. Genera, such as <jats:italic>Prevotella, Alloprevotella, Leptotrichia, Peptostreptococcus<\/jats:italic> and <jats:italic>Stomatobaculum<\/jats:italic>, exhibited significantly higher relative percentages in halitosis samples, when compared to healthy samples. <jats:italic>Peptostreptococcus<\/jats:italic>, <jats:italic>Alloprevotella<\/jats:italic>, <jats:italic>Eubacterium nodatum<\/jats:italic> and <jats:italic>Stomatobaculum<\/jats:italic> exhibited significantly positive correlations with the total number of VSCs. <jats:italic>Prevotella<\/jats:italic>, <jats:italic>Peptostreptococcus<\/jats:italic>, <jats:italic>Eubacterium nodatum<\/jats:italic> and <jats:italic>Alloprevotella<\/jats:italic> were correlated with increased H<jats:sub>2<\/jats:sub>S and CH<jats:sub>3<\/jats:sub>SH concentration values. <jats:italic>Bergeyella<\/jats:italic> was correlated with decreased total VSC, H<jats:sub>2<\/jats:sub>S and CH<jats:sub>3<\/jats:sub>SH concentration values. <jats:italic>Conclusion<\/jats:italic>: Microbial diversity was higher in the halitosis group than in the control group, and several bacteria were significantly correlated to halitosis. Furthermore, there were correlations between tongue bacterial composition structure and VSC gases. Tongue coating microbiota can offer important clues in the investigation of the pathogenesis and treatment of halitosis.<\/jats:p>","DOI":"10.1088\/1752-7163\/ab47b4","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T22:15:59Z","timestamp":1569449759000},"page":"016005","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":60,"title":["Relationship of tongue coating microbiome on volatile sulfur compounds in healthy and halitosis adults"],"prefix":"10.1088","volume":"14","author":[{"given":"Wei","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0401-3768","authenticated-orcid":false,"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4587-6394","authenticated-orcid":false,"given":"Xi-Ping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"jbrab47b4bib1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7163\/aaa3a1","article-title":"Tongue coating: its characteristics and role in intra-oral halitosis and general health-a review","volume":"12","author":"Seerangaiyan","year":"2018","journal-title":"J. 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