{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:38:46Z","timestamp":1768808326956,"version":"3.49.0"},"reference-count":64,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"crossref","award":["T42OH008436"],"award-info":[{"award-number":["T42OH008436"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Inhalation of smoke is shown to be associated with adverse respiratory outcomes in firefighters. Due to invasiveness of procedures to obtain airways lining fluid, the immediate responses of the target organ (i.e. lung) are secondarily assessed through biomarkers in blood and urine. The objective of this study was to identify changes in metabolic profile of exhaled breath condensate (EBC) and lung function of firefighters exposed to wildfires smoke. A total of 29 subjects were studied over 16 events; 14 of these subjects provided cross-shift EBC samples. The predominant types of non-exchangeable hydrogen in EBC were saturated oxygenated hydrogen, aliphatic alkyl and allylic. Non-exchangeable allylic and oxygenated hydrogen concentrations decreased in post-exposure EBC samples. Longer exposures were correlated with increased abundance of oxidized carbon in ketones, acids and esters. Post-exposure lung function declines (forced expiratory volume in 1 s (FEV\n                    <jats:sub>1<\/jats:sub>\n                    ): 0.08 l, forced vital capacity (FVC): 0.07 l, FEV\n                    <jats:sub>1<\/jats:sub>\n                    \/FVC: 0.03 l, peak expiratory flow (PEF): 0.39 l s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) indicated airways inflammation. They were related to exposure intensity (FEV\n                    <jats:sub>1<\/jats:sub>\n                    and FVC) and exposure duration (PEF). This study showed that EBC characterization of non-exchangeable hydrogen types by NMR may provide insights on EBC molecular compositions in response to smoke inhalation and facilitate targeted analysis to identify specific biomarkers.\n                  <\/jats:p>","DOI":"10.1088\/1752-7163\/abb761","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T18:48:53Z","timestamp":1599763733000},"page":"046010","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Characterization of exhaled breath condensate (EBC) non-exchangeable hydrogen functional types and lung function of wildland firefighters"],"prefix":"10.1088","volume":"14","author":[{"given":"Jordan","family":"Nelson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Cecile G","family":"Chalbot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Pavicevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0436-3784","authenticated-orcid":false,"given":"Ilias G","family":"Kavouras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"jbrabb761bib1","article-title":"National report of wildland fires and acres burned by state","author":"NICC","year":"2017","type":"web-resource"},{"key":"jbrabb761bib2","type":"book","article-title":"Working group on the evaluation of carcinogenic risks to humans","volume":"98","author":"IARC","year":"2010"},{"key":"jbrabb761bib3","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1080\/152873901300343470","type":"journal-article","article-title":"Characterization of volatile organic compounds in smoke at municipal structural fires","volume":"63","author":"Austin","year":"2001","journal-title":"J. Toxicol. Environ. Health A"},{"key":"jbrabb761bib4","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1002\/ajim.10023","type":"journal-article","article-title":"Municipal firefighter exposure groups, time spent at fires and use of self-contained-breathing-apparatus","volume":"40","author":"Austin","year":"2001","journal-title":"Am. J. Ind. Med."},{"key":"jbrabb761bib5","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.envint.2008.08.011","type":"journal-article","article-title":"Australian firefighters\u2019 exposure to air toxics during bushfire burns of autumn 2005 and 2006","volume":"35","author":"Reisen","year":"2009","journal-title":"Environ. Int."},{"key":"jbrabb761bib6","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.envint.2010.09.005","type":"journal-article","article-title":"Environment International","volume":"37","author":"Reisen","year":"2011"},{"key":"jbrabb761bib7","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1080\/08958370600985875","type":"journal-article","article-title":"Woodsmoke health effects: a review","volume":"19","author":"Naeher","year":"2007","journal-title":"Inhalation Toxicol."},{"key":"jbrabb761bib8","doi-asserted-by":"publisher","first-page":"6013","DOI":"10.1080\/15459624.2014.895372","type":"journal-article","article-title":"Exposures and cross-shift lung function declines in wildland firefighters","volume":"11","author":"Gaughan","year":"2014","journal-title":"J. Occup. Environ. Hyg."},{"key":"jbrabb761bib9","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1164\/ajrccm\/146.6.1469","type":"journal-article","article-title":"The effect of smoke inhalation on lung function and airway responsiveness in wildland fire fighters","volume":"146","author":"Liu","year":"1992","journal-title":"Am. Rev. Respir. Dis."},{"key":"jbrabb761bib10","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.envres.2019.03.060","type":"journal-article","article-title":"Wildland firefighter smoke exposure and risk of lung cancer and cardiovascular disease mortality","volume":"173","author":"Navarro","year":"2019","journal-title":"Environ. Res."},{"key":"jbrabb761bib11","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1136\/oemed-2013-101662","type":"journal-article","article-title":"Mortality and cancer incidence in a pooled cohort of US firefighters from San Francisco, Chicago and Philadelphia (1950-2009)","volume":"71","author":"Daniels","year":"2014","journal-title":"Occup. Environ. Med."},{"key":"jbrabb761bib12","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/ajim.21012","type":"journal-article","article-title":"Acute respiratory effects in firefighters","volume":"55","author":"Greven","year":"2012","journal-title":"Am. J. Ind. Med."},{"key":"jbrabb761bib13","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1080\/089583701753403953","type":"journal-article","article-title":"Rapid decline in sputum IL-10 concentration following occupational smoke exposure","volume":"14","author":"Burgess","year":"2002","journal-title":"Inhalation Toxicol."},{"key":"jbrabb761bib14","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1002\/ajim.22331","type":"journal-article","article-title":"Arterial stiffness, oxidative stress, and smoke exposure in wildland firefighters","volume":"57","author":"Gaughan","year":"2014","journal-title":"Am. J. Ind. Med."},{"key":"jbrabb761bib15","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1097\/JOM.0b013e3181754161","type":"journal-article","article-title":"Acute upper and lower respiratory effects in wildland firefighters","volume":"50","author":"Gaughan","year":"2008","journal-title":"J. Occup. Environ. Med."},{"key":"jbrabb761bib16","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7163\/aa61c5","type":"journal-article","article-title":"Serum and exhaled breath condensate leptin levels in asthmatic and obesity children: a pilot study","volume":"11","author":"Bodini","year":"2017","journal-title":"J. Breath Res."},{"key":"jbrabb761bib17","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/1471-2466-14-111","type":"journal-article","article-title":"Parameters of lung inflammation in asthmatic as compared to healthy children in a contaminated city","volume":"14","author":"Linares","year":"2014","journal-title":"BMC Pulmon. Med."},{"key":"jbrabb761bib18","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1007\/s11306-015-0805-8","type":"journal-article","article-title":"Inflammatory metabolites in exhaled breath condensate characterize the obese respiratory phenotype","volume":"11","author":"Paris","year":"2015","journal-title":"Metabolomics"},{"key":"jbrabb761bib19","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.atmosenv.2015.08.072","type":"journal-article","article-title":"1H NMR studies of water- and alkaline-soluble organic matter from fine urban atmospheric aerosols","volume":"119","author":"Lopes","year":"2015","journal-title":"Atmos. Environ."},{"key":"jbrabb761bib20","doi-asserted-by":"publisher","first-page":"6107","DOI":"10.1021\/pr5010407","type":"journal-article","article-title":"NMR metabolomic analysis of exhaled breath condensate of asthmatic patients at two different temperatures","volume":"13","author":"Motta","year":"2014","journal-title":"J. Proteome Res."},{"key":"jbrabb761bib21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11306-013-0572-3","type":"journal-article","article-title":"Phenotyping COPD by 1H NMR metabolomics of exhaled breath condensate","volume":"10","author":"Bertini","year":"2013","journal-title":"Metabolomics"},{"key":"jbrabb761bib22","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1021\/pr301171p","type":"journal-article","article-title":"Separating smoking-related diseases using NMR-based metabolomics of exhaled breath condensate","volume":"12","author":"De Laurentiis","year":"2013","journal-title":"J. Proteome Res."},{"key":"jbrabb761bib23","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/403260","type":"journal-article","article-title":"Exploring airway diseases by nmr-based metabonomics: A review of application to exhaled breath condensate","volume":"2011","author":"Matteo","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"jbrabb761bib24","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1183\/09031936.00072408","type":"journal-article","article-title":"Metabonomic analysis of exhaled breath condensate in adults by nuclear magnetic resonance spectroscopy","volume":"32","author":"De Laurentiis","year":"2008","journal-title":"Eur. Respir. J."},{"key":"jbrabb761bib25","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1183\/1025448x.00019609","type":"journal-article","article-title":"Exhaled breath condensate: metabolomics","volume":"49","author":"Carraro","year":"2010","journal-title":"Eur. Respir. Mon."},{"key":"jbrabb761bib26","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/9\/3\/036001","type":"journal-article","article-title":"Biomarkers of inflammation in persons with chronic tetraplegia","volume":"9","author":"Radulovic","year":"2015","journal-title":"J. Breath Res."},{"key":"jbrabb761bib27","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3109\/1354750X.2014.988646","type":"journal-article","article-title":"Analysis of inflammatory cytokines in human blood, breath condensate, and urine using a multiplex immunoassay platform","volume":"20","author":"Stiegel","year":"2015","journal-title":"Biomarkers"},{"key":"jbrabb761bib28","doi-asserted-by":"publisher","first-page":"534","DOI":"10.5604\/12321966.1120597","type":"journal-article","article-title":"Change in airway inflammatory markers in Danish energy plant workers during a working week","volume":"21","author":"Zheng","year":"2014","journal-title":"Ann. Agric. Environ. Med."},{"key":"jbrabb761bib29","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/all.12063","type":"journal-article","article-title":"Asthma severity in childhood and metabolomic profiling of breath condensate","volume":"68","author":"Carraro","year":"2013","journal-title":"Allergy"},{"key":"jbrabb761bib30","doi-asserted-by":"publisher","first-page":"13894","DOI":"10.3390\/ijms131113894","type":"journal-article","article-title":"Profiling the proteome of exhaled breath condensate in healthy smokers and COPD patients by LC-MS\/MS","volume":"13","author":"Fumagalli","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"jbrabb761bib31","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.toxlet.2018.10.018","type":"journal-article","article-title":"Biomonitoring of workers using nuclear magnetic resonance-based metabolomics of exhaled breath condensate: A pilot study","volume":"298","author":"Maniscalco","year":"2018","journal-title":"Toxicol. Lett."},{"key":"jbrabb761bib32","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1080\/15287394.2012.690686","type":"journal-article","article-title":"Wildland smoke exposure values and exhaled breath indicators in firefighters","volume":"75","author":"Miranda","year":"2012","journal-title":"J. Toxicol. Environ. Health A"},{"key":"jbrabb761bib33","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1080\/19338244.2018.1562413","type":"journal-article","article-title":"Measuring acute pulmonary responses to occupational wildland fire smoke exposure using exhaled breath condensate","volume":"75","author":"Wu","year":"2020","journal-title":"Arch. Environ. Occup. Health"},{"key":"jbrabb761bib34","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/JOM.0000000000000688","type":"journal-article","article-title":"Measured pulmonary and systemic markers of inflammation and oxidative stress following wildland firefighter simulations","volume":"58","author":"Ferguson","year":"2016","journal-title":"J. Occup. Environ. Med."},{"key":"jbrabb761bib35","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1080\/15459620490490101","type":"journal-article","article-title":"Baseline measurements of smoke exposure among wildland firefighters","volume":"1","author":"Reinhardt","year":"2004","journal-title":"J. Occup. Environ. Hyg."},{"key":"jbrabb761bib36","doi-asserted-by":"publisher","DOI":"10.1007\/s12403-020-00366-5","type":"web-resource","article-title":"Physicochemical characterization of personal exposures to smoke aerosol and PAHs of wildland firefighters in prescribed fires","author":"Nelson","year":"2020"},{"key":"jbrabb761bib37","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/1465-9921-10-78","type":"journal-article","article-title":"Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients","volume":"10","author":"Koczulla","year":"2009","journal-title":"Respir. Res."},{"key":"jbrabb761bib38","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1039\/c3em30906a","type":"journal-article","article-title":"Characterization of a portable method for the collection of exhaled breath condesnate and subsequent analysis of metal content","volume":"15","author":"Fox","year":"2013","journal-title":"Environ. Sci. Process. Impacts"},{"key":"jbrabb761bib39","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.atmosenv.2015.12.067","type":"journal-article","article-title":"Characterization of water-soluble organic matter in urban aerosol by (1)H-NMR spectroscopy","volume":"128","author":"Chalbot","year":"2016","journal-title":"Atmos. Environ."},{"key":"jbrabb761bib40","doi-asserted-by":"publisher","DOI":"10.1177\/1934578x19849972","type":"journal-article","article-title":"Nuclear magnetic resonance characterization of water soluble organic carbon of atmospheric aerosol types","volume":"14","author":"Chalbot","year":"2019","journal-title":"Nat. Prod. Commun."},{"key":"jbrabb761bib41","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00965-2016","type":"journal-article","article-title":"A european respiratory society technical standard: exhaled biomarkers in lung disease","volume":"49","author":"Horv\u00e1th","year":"2017","journal-title":"Eur. Respir. J."},{"key":"jbrabb761bib42","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/chromsci\/bmt150","type":"journal-article","article-title":"Determining urea levels in exhaled breath condensate with minimal preparation steps and classic LC-MS.","volume":"52","author":"Pitiranggon","year":"2014","journal-title":"J. Chromatogr. Sci."},{"key":"jbrabb761bib43","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1164\/ajrccm.159.1.9712108","type":"journal-article","article-title":"Spirometric reference values from a sample of the general U.S. population","volume":"159","author":"Hankinson","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"jbrabb761bib44","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1136\/oem.2008.040857","type":"journal-article","article-title":"Lung function and indicators of exposure to indoor and outdoor particulate matter among asthma and COPD patients","volume":"67","author":"de Hartog","year":"2010","journal-title":"Occup. Environ. Med."},{"key":"jbrabb761bib45","doi-asserted-by":"publisher","first-page":"937","DOI":"10.2307\/2533554","type":"journal-article","article-title":"Sample size calculation for studies with correlated observations","volume":"53","author":"Liu","year":"1997","journal-title":"Biometrics"},{"key":"jbrabb761bib46","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1093\/ije\/dyt221","type":"journal-article","article-title":"Fixed effects analysis of repeated measures data","volume":"43","author":"Gunasekara","year":"2014","journal-title":"Int. J. Epidemiol."},{"key":"jbrabb761bib47","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.jth.2016.08.006","type":"journal-article","article-title":"Changes in walking, body mass index, and cardiometabolic risk factors following residential relocation: longitudinal results from the CARDIA study","volume":"3","author":"Braun","year":"2016","journal-title":"J. Transp. Health"},{"key":"jbrabb761bib48","doi-asserted-by":"publisher","first-page":"4079","DOI":"10.1029\/2001gl013418","type":"journal-article","article-title":"A simplified model of the water soluble organic component of atmospheric aerosols","volume":"28","author":"Fuzzi","year":"2001","journal-title":"Geophys. Res. Lett."},{"key":"jbrabb761bib49","doi-asserted-by":"publisher","first-page":"L953\u2013L961","DOI":"10.1152\/ajplung.00335.2014","type":"journal-article","article-title":"Lactate as substrate for mitochondrial respiration in alveolar epithelial type II cells","volume":"308","author":"Lottes","year":"2015","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"jbrabb761bib50","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1038\/ni1275","type":"journal-article","article-title":"Immune cell migration in inflammation: present and future therapeutic targets","volume":"6","author":"Luster","year":"2005","journal-title":"Nat. Immunol."},{"key":"jbrabb761bib51","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature11986","type":"journal-article","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"jbrabb761bib52","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1080\/13547500802688194","type":"journal-article","article-title":"Metabolomic analysis of bronchoalveolar lavage fluid from cystic fibrosis patients","volume":"14","author":"Wolak","year":"2009","journal-title":"Biomarkers"},{"key":"jbrabb761bib53","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1002\/tox.22369","type":"journal-article","article-title":"Particulate emissions from the combustion of birch, beech, and spruce logs cause different cytotoxic responses in A549 cells","volume":"32","author":"Kasurinen","year":"2017","journal-title":"Environ. Toxicol."},{"key":"jbrabb761bib54","doi-asserted-by":"publisher","first-page":"835","DOI":"10.3109\/08958378.2011.617790","type":"journal-article","article-title":"Lung function changes in wildland firefighters working at prescribed burns","volume":"23","author":"Adetona","year":"2011","journal-title":"Inhalation Toxicol."},{"key":"jbrabb761bib55","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1034\/j.1399-3003.2000.15b05.x","type":"journal-article","article-title":"Baseline airway hyperresponsiveness and its reversible component: role of airway inflammation and airway calibr","volume":"15","author":"Ichinose","year":"2000","journal-title":"Eur. Respir. J."},{"key":"jbrabb761bib56","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1164\/ajrccm.151.5.7735580","type":"journal-article","article-title":"Which Index of peak expiratory flow is most useful in the management of stable asthma?","volume":"151","author":"Reddel","year":"1995","journal-title":"Am J Respir Crit Care Med."},{"key":"jbrabb761bib57","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3109\/02770909709075654","type":"journal-article","article-title":"Comparison between peak expiratory flow and forced expiratory volume in one second (FEV1) during bronchoconstriction induced by different stimuli","volume":"34","author":"Giannini","year":"1997","journal-title":"J. Asthma"},{"key":"jbrabb761bib58","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1542\/peds.105.2.354","type":"journal-article","article-title":"Can peak expiratory flow predict airflow obstruction in children with asthma?","volume":"105","author":"Eid","year":"2000","journal-title":"Pediatrics"},{"key":"jbrabb761bib59","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1183\/09031936.94.07050881","type":"journal-article","article-title":"Factors influencing the occurence of airway hyperreactivity in the general population: the importance of atopy and airway calibre","volume":"7","author":"Britton","year":"1994","journal-title":"Eru. Respir. J."},{"key":"jbrabb761bib60","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0091-6749(88)90045-0","type":"journal-article","article-title":"Persisting airway obstruction in asymptomatic children with asthma with normal peak expiratoru flow rates","volume":"82","author":"Ferguson","year":"1987","journal-title":"J. Allergy Clin. Immunol."},{"key":"jbrabb761bib61","first-page":"438","type":"journal-article","article-title":"The italian working group on the use of peak expiratory flow rate (PEFR) in asthma","volume":"14","author":"Paggiaro","year":"1993","journal-title":"Eur. Respir. Rev."},{"key":"jbrabb761bib62","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1183\/09031936.93.02101008","type":"journal-article","article-title":"Fatal asthma in a young patient with severe broncial hyperresponsiveness but stable peak flow records","volume":"2","author":"Saetta","year":"1989","journal-title":"Eur. Respir. J."},{"key":"jbrabb761bib63","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1183\/09031936.04.00077803","type":"journal-article","article-title":"Parameters associated with persistent airflow obstruction in chronic severe asthma","volume":"24","author":"Bumbacea","year":"2004","journal-title":"Eur. Respir. J."},{"key":"jbrabb761bib64","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1002\/(sici)1097-0274(199705)31:5<503::aid-ajim3>3.0.co;2-u","type":"journal-article","article-title":"Pulmonary function and respiratory symptoms in forest firefighters","volume":"31","author":"Betchley","year":"1997","journal-title":"Am. J. Ind. Med."}],"container-title":["Journal of Breath Research"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/abb761","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/abb761\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/abb761","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/abb761\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/abb761\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/abb761","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/abb761\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/abb761\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/abb761\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/abb761\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/abb761\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/abb761","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T14:18:37Z","timestamp":1768659517000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/abb761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,24]]},"references-count":64,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,9,24]]},"published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1752-7163\/abb761","relation":{},"ISSN":["1752-7155","1752-7163"],"issn-type":[{"value":"1752-7155","type":"print"},{"value":"1752-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,24]]},"assertion":[{"value":"Characterization of exhaled breath condensate (EBC) non-exchangeable hydrogen functional types and lung function of wildland firefighters","name":"article_title","label":"Article Title"},{"value":"Journal of Breath Research","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2020 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-05-01","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-09-10","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-09-24","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}