{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:23:45Z","timestamp":1785860625906,"version":"3.56.0"},"reference-count":72,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100007114","name":"Ralph W. and Grace M. Showalter Research Trust Fund","doi-asserted-by":"crossref","award":["Grant 41000747"],"award-info":[{"award-number":["Grant 41000747"]}],"id":[{"id":"10.13039\/100007114","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tetrachloroethylene (PCE) is a widely utilized volatile chemical in industrial applications, including dry cleaning and metal degreasing. Exposure to PCE potentially presents a significant health risk to workers as well as communities near contamination sites. Adverse health effects arise not only from PCE, but also from PCE degradation products, such as trichloroethylene (TCE) and vinyl chloride (VC). PCE, TCE, and VC can contaminate water, soil, and air, leading to exposure through multiple pathways, including inhalation, ingestion, and dermal contact. This study focused on a community setting in Martinsville, Indiana, a working-class Midwestern community in the United States, where extensive PCE contamination has occurred due to multiple contamination sites (referring to \u2018plumes\u2019), including a Superfund site. Utilizing proton transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS), PCE, TCE, and VC concentrations were measured in the exhaled breath of 73 residents from both within and outside the plume areas. PCE was detected in 66 samples, TCE in 26 samples, and VC in 68 samples. Our results revealed a significant positive correlation between the concentrations of these compounds in exhaled breath and indoor air (Pearson correlation coefficients: PCE = 0.75, TCE = 0.71, and VC = 0.89). This study confirms the presence of PCE and its degradation products in exhaled breath in a community exposure investigation, demonstrating the potential of using exhaled breath analysis in monitoring exposure to environmental contaminants. This study showed the feasibility of utilizing PTR-TOF-MS in community investigations to assess exposure to PCE and its degradation products by measuring these compounds in exhaled breath and indoor air.<\/jats:p>","DOI":"10.1088\/1752-7163\/ad67fd","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T22:51:00Z","timestamp":1722034260000},"page":"046008","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of tetrachloroethylene (PCE) and its degradation products in human exhaled breath and indoor air in a community setting"],"prefix":"10.1088","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9067-3449","authenticated-orcid":true,"given":"Jung Hyun","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaina K","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8412-5323","authenticated-orcid":true,"given":"Marwan","family":"Alajlouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1011-4100","authenticated-orcid":true,"given":"Brandon E","family":"Boor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9767-5343","authenticated-orcid":false,"given":"Antonios","family":"Tasoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8121-6927","authenticated-orcid":false,"given":"Sa","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"jbrad67fdbib1","author":"National Research Council, Division on Earth, Life Studies, Commission on Geosciences and Committee on Ground Water Cleanup Alternatives","year":"1994"},{"key":"jbrad67fdbib2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/rem.20178","article-title":"Integrated approach to PCE\u2010impacted site characterization, site management, and enhanced bioremediation","volume":"18","author":"Davis","year":"2008","journal-title":"Remediation"},{"key":"jbrad67fdbib3","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.ntt.2012.04.001","article-title":"Adult neuropsychological performance following prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water","volume":"34","author":"Janulewicz","year":"2012","journal-title":"Neurotoxicol. 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