{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:11:13Z","timestamp":1788606673012,"version":"build-2803163510"},"reference-count":23,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/page\/copyright"},{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100007316","name":"Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"crossref","award":["5R44CA203019 \u2013 02"],"award-info":[{"award-number":["5R44CA203019 \u2013 02"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Previous studies have reported volatile organic compounds (VOCs) in the breath as biomarkers of breast cancer. These biomarkers may be derived from cancer-associated fibroblasts, in which oxidative stress degrades polyunsaturated fatty acids to volatile alkanes and methylated alkane derivatives that are excreted in the breath. We evaluated a rapid point-of-care test for breath VOC biomarkers as predictors of breast cancer and abnormal mammograms. We studied 593 women aged\n                    <jats:inline-formula>\n                      <jats:tex-math>\n                        \n                      <\/jats:tex-math>\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" overflow=\"scroll\">\n                        <mml:mrow>\n                          <mml:mtext>\u2a7e<\/mml:mtext>\n                        <\/mml:mrow>\n                      <\/mml:math>\n                    <\/jats:inline-formula>\n                    18 yr referred to three sites for mammography for a symptomatic breast-related concern (e.g. breast mass, nipple discharge). A rapid point-of-care breath testing system collected and concentrated alveolar breath VOCs on a sorbent trap and analyzed them with gas chromatography and surface acoustic wave detection in &lt;6 min. Breath VOC chromatograms were randomly assigned to a training set or to a validation set. Monte Carlo analysis identified significant breath VOC biomarkers of breast cancer and abnormal mammograms in the training set, and these biomarkers were incorporated into a multivariate algorithm to predict disease in the validation set.\n                    <jats:italic>Prediction of breast cancer:<\/jats:italic>\n                    50 women had biopsy-proven breast cancer (invasive cancer 41, ductal non-invasive cancer 9)\n                    <jats:italic>Unsplit data set:<\/jats:italic>\n                    breath VOCs identified breast cancer with 83% accuracy (area under curve of receiver operating characteristic), 82% sensitivity and 77.1% specificity.\n                    <jats:italic>Split data sets:<\/jats:italic>\n                    training set breath VOCs identified breast cancer with 80.3% accuracy, 84% sensitivity and 74.3% specificity. Corresponding values in the validation set were 68%% accuracy, 72.4% sensitivity and 61.5% specificity.\n                    <jats:italic>Prediction of BIRADS 4 and 5 mammograms (versus BIRADS 1, 2 and 3): unsplit data set:<\/jats:italic>\n                    breath VOCs identified abnormal mammograms with 76.2% accuracy.\n                    <jats:italic>Split data sets:<\/jats:italic>\n                    breath VOCs identified abnormal mammograms with 74.2% accuracy, 73.3% sensitivity and 60% specificity. Corresponding values in the validation set were 60.5% accuracy, 64.2% sensitivity and 51% specificity. A rapid point-of-care test for breath VOC biomarkers predicted risk of breast cancer and abnormal mammograms in women with breast-related symptoms.\n                  <\/jats:p>","DOI":"10.1088\/1752-7163\/ad7a20","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T19:10:30Z","timestamp":1726168230000},"page":"046011","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Rapid point-of-care breath test predicts breast cancer and abnormal mammograms in symptomatic women"],"prefix":"10.1088","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9889-131X","authenticated-orcid":true,"given":"Michael","family":"Phillips","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese B","family":"Bevers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda Hovanessian","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Pappas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"jbrad7a20bib1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1046\/j.1524-4741.2003.09309.x","article-title":"Volatile markers of breast cancer in the breath","volume":"9","author":"Phillips","year":"2003","journal-title":"Breast J."},{"key":"jbrad7a20bib2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s10549-006-9176-1","article-title":"Prediction of breast cancer using volatile biomarkers in the breath","volume":"99","author":"Phillips","year":"2006","journal-title":"Breast Cancer Res. Treat."},{"key":"jbrad7a20bib3","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/4\/2\/026003","article-title":"Volatile biomarkers in the breath of women with breast cancer","volume":"4","author":"Phillips","year":"2010","journal-title":"J. Breath Res."},{"key":"jbrad7a20bib4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090226","article-title":"Rapid point-of-care breath test for biomarkers of breast cancer and abnormal mammograms","volume":"9","author":"Phillips","year":"2014","journal-title":"PLoS One"},{"key":"jbrad7a20bib5","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7163\/aa549b","article-title":"Breath mass ion biomarkers of breast cancer","volume":"11","author":"Phillips","year":"2016","journal-title":"J. Breath Res."},{"key":"jbrad7a20bib6","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/sj.bjc.6605810","article-title":"Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors","volume":"103","author":"Peng","year":"2010","journal-title":"Br. J. Cancer"},{"key":"jbrad7a20bib7","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1002\/stem.2412","article-title":"Mesenchymal stem cells are recruited and activated into carcinoma-associated fibroblasts by prostate cancer microenvironment-derived TGF-beta1","volume":"34","author":"Barcellos-de-souza","year":"2016","journal-title":"Stem Cells"},{"key":"jbrad7a20bib8","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.diff.2017.07.002","article-title":"Interaction of prostate carcinoma-associated fibroblasts with human epithelial cell lines in vivo","volume":"96","author":"Sasaki","year":"2017","journal-title":"Differentiation"},{"key":"jbrad7a20bib9","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1080\/10715762.2017.1285024","article-title":"Torulene and torularhodin, protects human prostate stromal cells from hydrogen peroxide-induced oxidative stress damage through the regulation of Bcl-2\/Bax mediated apoptosis","volume":"51","author":"Du","year":"2017","journal-title":"Free Radical Res."},{"key":"jbrad7a20bib10","first-page":"163","article-title":"The hydrocarbon breath test in the study of lipid peroxidation: principles and practice","volume":"15","author":"Kneepkens","year":"1992","journal-title":"Clin. Invest. Med."},{"key":"jbrad7a20bib11","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0891-5849(94)90110-4","article-title":"The potential of the hydrocarbon breath test as a measure of lipid peroxidation","volume":"17","author":"Kneepkens","year":"1994","journal-title":"Free Radical Biol. Med."},{"key":"jbrad7a20bib12","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3390\/cancers2010032","article-title":"Oxidative stress and exhaled breath analysis: a promising tool for detection of lung cancer","volume":"2","author":"Chan","year":"2010","journal-title":"Cancers"},{"key":"jbrad7a20bib13","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/S0891-5849(00)00189-1","article-title":"Breath alkanes as a marker of oxidative stress in different clinical conditions","volume":"28","author":"Aghdassi","year":"2000","journal-title":"Free Radical Biol. Med."},{"key":"jbrad7a20bib14","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.tube.2012.04.002","article-title":"Point-of-care breath test for biomarkers of active pulmonary tuberculosis","volume":"92","author":"Phillips","year":"2012","journal-title":"Tuberculosis"},{"key":"jbrad7a20bib15","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.cca.2008.02.021","article-title":"Detection of lung cancer using weighted digital analysis of breath biomarkers","volume":"393","author":"Phillips","year":"2008","journal-title":"Clin. Chim. Acta"},{"key":"jbrad7a20bib16","first-page":"575","article-title":"Diet and oxidative stress in breast, colon and prostate cancer patients: a case-control study","volume":"48","author":"Hietanen","year":"1994","journal-title":"Eur. J. Clin. Nutrition"},{"key":"jbrad7a20bib17","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1177\/000313481107700632","article-title":"Breath analysis by mass spectrometry: a new tool for breast cancer detection?","volume":"77","author":"Patterson","year":"2011","journal-title":"Am. Surg."},{"key":"jbrad7a20bib18","first-page":"730","article-title":"Volatile organic compounds (VOCs) in exhaled breath of patients with breast cancer in a clinical setting","volume":"83","author":"Mangler","year":"2012","journal-title":"Ginekol. Polska"},{"key":"jbrad7a20bib19","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1166\/jbn.2013.1651","article-title":"Detection and identification of breast cancer volatile organic compounds biomarkers using highly-sensitive single nanowire array on a chip","volume":"9","author":"Xu","year":"2013","journal-title":"J. Biomed. Nanotechnol."},{"key":"jbrad7a20bib20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1177\/1534735405285096","article-title":"Diagnostic accuracy of canine scent detection in early- and late-stage lung and breast cancers","volume":"5","author":"McCulloch","year":"2006","journal-title":"Integr. Cancer Ther."},{"key":"jbrad7a20bib21","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/B978-0-12-407190-2.00003-4","article-title":"Role of oxidative stress and the microenvironment in breast cancer development and progression","volume":"119","author":"Jezierska-Drutel","year":"2013","journal-title":"Adv. Cancer Res."},{"key":"jbrad7a20bib22","doi-asserted-by":"publisher","DOI":"10.1038\/srep43969","article-title":"Volatile metabolomic signature of human breast cancer cell lines","volume":"7","author":"Silva","year":"2017","journal-title":"Sci. Rep."},{"key":"jbrad7a20bib23","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/6\/3\/036007","article-title":"Data interpretation in breath biomarker research: pitfalls and directions","volume":"6","author":"Miekisch","year":"2012","journal-title":"J. Breath Res."}],"container-title":["Journal of Breath Research"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/ad7a20","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/ad7a20\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/ad7a20","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/ad7a20\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/ad7a20\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/ad7a20\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/ad7a20\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/ad7a20\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T08:21:01Z","timestamp":1727079661000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/ad7a20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,23]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,9,23]]},"published-print":{"date-parts":[[2024,10,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1752-7163\/ad7a20","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.04.07.20042895","asserted-by":"object"}]},"ISSN":["1752-7155","1752-7163"],"issn-type":[{"value":"1752-7155","type":"print"},{"value":"1752-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,23]]},"assertion":[{"value":"Rapid point-of-care breath test predicts breast cancer and abnormal mammograms in symptomatic women","name":"article_title","label":"Article Title"},{"value":"Journal of Breath Research","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2024 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2024-02-27","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-09-12","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-09-23","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}