{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:10:34Z","timestamp":1793373034052,"version":"4.5.0"},"reference-count":24,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100015803","name":"BC Cancer Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015803","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Exhaled breath volatile organic compounds (VOCs) are often collected and stored in sorbent tubes before thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS) analysis. Information about the stability of VOCs during storage is needed to account for potential artifacts and monitor for losses. Additionally, information about the stability of VOC standards in solution is required to assess their performance as quality control and internal standards. We evaluated the stability of a standard mixture of 42 VOCs in dual-sorbent tubes containing Tenax\u00ae TA and Carbotrap 1TD over 60 d at commonly used storage conditions: room temperature (\u223c21 \u00b0C), 4 \u00b0C, and \u221280 \u00b0C. The same 42 VOCs were also evaluated for their stability in methanol over 60 d while stored at \u221220 \u00b0C. All samples were analyzed using TD-GC-MS. During storage, most VOCs were stable on sorbent after 60 d: 36\/42 (86%), 39\/42 (93%), and 41\/42 (98%) had not statistically changed for room temperature, 4 \u00b0C and \u221280 \u00b0C, respectively, based on Spearman rank correlation coefficients and linear regression analysis. The isotopically labeled VOCs tested here are well-suited to serve as internal standards for pre-analysis or storage. Degradation of VOCs in solution was apparent after 60 d: 27\/42 (64%) of VOCs had statistically decreased. The total VOC mixture had dropped to 90% of its original intensity after \u223c22 d and a subset of VOCs typically used as internal standards dropped to 90% in \u223c16 d. Analysts using similar mixtures should make a fresh solution at least every two weeks to ensure analytical accuracy. This study provides important insights into storage practices for both sorbent tubes and standard solutions, guiding analysts toward improved reliability and accuracy in exhaled breath analysis.<\/jats:p>","DOI":"10.1088\/1752-7163\/ada05c","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T22:53:24Z","timestamp":1734476004000},"page":"026001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Stability of volatile organic compounds in thermal desorption tubes and in solution"],"prefix":"10.1088","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4511-8526","authenticated-orcid":true,"given":"Kristian J","family":"Kiland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0065-6407","authenticated-orcid":false,"given":"Lucas","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9748-1290","authenticated-orcid":true,"given":"Scott A","family":"Borden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3964-1492","authenticated-orcid":false,"given":"Stephen","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4898-2229","authenticated-orcid":true,"given":"Renelle","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"jbrada05cbib1","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1136\/thoraxjnl-2020-215667","article-title":"Breathomics for the clinician: the use of volatile organic compounds in respiratory diseases","volume":"76","author":"Ibrahim","year":"2021","journal-title":"Thorax"},{"key":"jbrada05cbib2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1295955","article-title":"GC-MS-based metabolomics of volatile organic compounds in exhaled breath: applications in health and disease. 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