{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:09:19Z","timestamp":1787008159427,"version":"build-2736575974"},"reference-count":46,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/page\/copyright"},{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>\n                    <jats:bold>Abstract<\/jats:bold>\n                  <\/jats:title>\n                  <jats:p>\n                    Sarcoidosis is considered a T-helper (Th) 1 related disease, but a transition from Th1 to Th2 pathway activation has been postulated in sarcoidosis-associated pulmonary fibrosis (SAPF). Fraction of exhaled nitric oxide (F\n                    <jats:sub>E<\/jats:sub>\n                    NO) is a marker of Th2 airway inflammation, but alveolar concentration of nitric oxide (C\n                    <jats:sub>A<\/jats:sub>\n                    NO) can be measured to assess Th2 inflammation in the periphery of the lung. The aim of this study is to assess whether C\n                    <jats:sub>A<\/jats:sub>\n                    NO can be considered a biomarker of SAPF or active pulmonary sarcoidosis. In this single-center retrospective study, we compared exhaled NO levels of patients with pulmonary sarcoidosis without fibrosis (\n                    <jats:italic>N<\/jats:italic>\n                    = 11) with those obtained from patients with SAPF (\n                    <jats:italic>N<\/jats:italic>\n                    = 15). Clinical data, as well as respiratory function tests, were also analyzed. F\n                    <jats:sub>E<\/jats:sub>\n                    NO (28.5 \u00b1 16 ppb vs 30.9 \u00b1 17.2 ppb,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.72) and C\n                    <jats:sub>A<\/jats:sub>\n                    NO (4.4 \u00b1 3.5 ppb vs 3.2 \u00b1 1.7 ppb,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.73) levels did not differ significantly between patients with or without SAPF, even when dividing them according to treatment or disease activity. C\n                    <jats:sub>A<\/jats:sub>\n                    NO appeared reduced in patients with active sarcoidosis (2.1 \u00b1 0.8 ppb vs 4.1 \u00b1 3 ppb,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). In conclusion, C\n                    <jats:sub>A<\/jats:sub>\n                    NO cannot be considered a biomarker of SAPF. Its lower level in patients with active disease confirms the prevalence of Th1 inflammation in granuloma formation and suggests its potential role as a biomarker of active pulmonary sarcoidosis, but further studies with larger samples are needed to confirm this hypothesis.\n                  <\/jats:p>","DOI":"10.1088\/1752-7163\/adac82","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T17:51:33Z","timestamp":1737481893000},"page":"026003","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Alveolar nitric oxide concentration as a potential biomarker of fibrosis and active disease in pulmonary sarcoidosis: a pilot study"],"prefix":"10.1088","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5745-7701","authenticated-orcid":false,"given":"Stefano","family":"Levra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Giannoccaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Chernovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1866-5206","authenticated-orcid":false,"given":"Vitina","family":"Carriero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1976-7466","authenticated-orcid":true,"given":"Elisa","family":"Arrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-0394","authenticated-orcid":false,"given":"Francesca","family":"Bertolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8436-3655","authenticated-orcid":true,"given":"Maurizio","family":"Balbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pizzimenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3876-8587","authenticated-orcid":false,"given":"Giuseppe","family":"Guida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1826-5018","authenticated-orcid":true,"given":"Fabio L M","family":"Ricciardolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"jbradac82bib1","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1042\/bj3570593","article-title":"Nitric oxide synthases: structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2024-11-13","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-01-21","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-01-29","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}