{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:19:07Z","timestamp":1790651947542,"version":"4.1.0"},"reference-count":31,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The non-invasive biological marker exhaled nitric oxide (FE<jats:sub>NO<\/jats:sub>) is increasingly used in asthma, but its clinical role in COPD is less established. FE<jats:sub>NO<\/jats:sub> has been reported to be both high and low outside the COPD exacerbation period. The study aimed to follow FE<jats:sub>NO<\/jats:sub> values over two years during stable conditions in a cohort of COPD subjects participating in the TIE-study (Tools Identifying Exacerbation). The follow-up study included 353 subjects who attended three visits one year apart. The subjects that were ex-smokers (<jats:italic>n<\/jats:italic> = 265) had higher FE<jats:sub>NO,50<\/jats:sub> values (median and IQR) compared with current smokers (<jats:italic>n<\/jats:italic> = 88), at inclusion 15 (10, 24) versus 9 (7, 15) ppb, after one year 15 (10, 24) versus 10 (7, 18) ppb, and after two years 14 (9, 22) versus 10 (7, 17) ppb, all <jats:italic>p<\/jats:italic> &lt; 0.001. All subjects were further divided into two FE<jats:sub>NO<\/jats:sub> groups: &lt;20 ppb (72%) and \u2a7e20 ppb (28%). After one year, 81% of the participants remained in the low group and 65% in the high FE<jats:sub>NO<\/jats:sub> group. After two years, 71% remained in the low group and 52% in the high FE<jats:sub>NO<\/jats:sub> group. The persistent low FE<jats:sub>NO<\/jats:sub> group had statistically significantly lower FEV<jats:sub>1<\/jats:sub>%pred and FVC%pred compared to the high FE<jats:sub>NO<\/jats:sub> group for all three visits. Among the ex-smokers, the proportion of subjects reporting dyspnoea (mMRC \u2a7e 2) was higher in the persistent low FE<jats:sub>NO<\/jats:sub> group than in the persistent high FE<jats:sub>NO<\/jats:sub> group at all three visits. In conclusion, good consistency in FE<jats:sub>NO<\/jats:sub> over two years is promising for monitoring FE<jats:sub>NO<\/jats:sub> during stable disease. COPD subjects with persistent low FE<jats:sub>NO<\/jats:sub> had poorer lung function and reported more dyspnoea than subjects with persistent high FE<jats:sub>NO<\/jats:sub>.<\/jats:p>","DOI":"10.1088\/1752-7163\/adfd04","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T22:50:47Z","timestamp":1755643847000},"page":"046005","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Exhaled nitric oxide stability over two years in relation to COPD outcomes"],"prefix":"10.1088","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6392-6092","authenticated-orcid":true,"given":"Marieann","family":"H\u00f6gman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5093-6980","authenticated-orcid":false,"given":"Christer","family":"Janson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0590-0417","authenticated-orcid":false,"given":"Andreas","family":"Palm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8497-7326","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"St\u00e4llberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-5023","authenticated-orcid":true,"given":"Kristina","family":"Br\u00f6ms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3107-4462","authenticated-orcid":false,"given":"Karin","family":"Lisspers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3671-5046","authenticated-orcid":false,"given":"Maria","family":"H\u00e5rdstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5970-5836","authenticated-orcid":false,"given":"Amir","family":"Farkhooy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4098-7765","authenticated-orcid":true,"given":"Andrei","family":"Malinovschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"jbradfd04bib1","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1164\/rccm.9120-11ST","article-title":"An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications","volume":"184","author":"Dweik","year":"2011","journal-title":"Am. 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Published by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2025-06-16","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-08-19","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-08-29","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}