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Breath Res."],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hyperglycemia can shorten red blood cell (RBC) lifespan, leading to incorrectly measured glycated hemoglobin (HbA1c) values. Correcting for the impact of the RBC lifespan on HbA1c is a critical issue in clinical practice. Before establishing a generally accepted correction formula to account for the impact of RBC lifespan on HbA1c, it is necessary to investigate the duration necessary to emake the hyperglycemia-induced RBC lifespan shortening reverse to normal. This longitudinal clinical trial examined the RBC lifespan in 31 hospitalized patients with type 2 diabetes mellitus by measuring the concentration of exhaled endogenous carbon monoxide. The 31 non-smoking patients with type 2 diabetes were all admitted due to blood glucose (BG) imbalance, and their RBC lifespan was tested at admission, discharge (after \u223c2 weeks of intensive glycemic control), and 3 months after discharge. During the period from admission to three months after discharge, RBC lifespan significantly increased in the patients as they underwent drug treatment to control BG (<jats:italic>P<\/jats:italic> &lt; 0.05) effectively. HbA1c, fasting plasma glucose, and 2 h postprandial glucose decreased significantly. This study found that (i) a shortened RBC lifespan caused by hyperglycemia is reversible, and (ii) the time required for this reversal is three months of effective drug treatment to control BG.<\/jats:p>","DOI":"10.1088\/1752-7163\/adfe0d","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T22:51:08Z","timestamp":1755816668000},"page":"046006","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of the CO breath test to explore the reversibility of hyperglycemia\u2019s impact on erythrocyte lifespan"],"prefix":"10.1088","volume":"19","author":[{"given":"Chen-Fang","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4932-4562","authenticated-orcid":true,"given":"Yong-Jian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1837-5671","authenticated-orcid":true,"given":"Yong-Qiang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-Ling","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Yi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Ting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-He","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"jbradfe0dbib1","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1210\/jc.2007-2174","type":"journal-article","article-title":"A new look at screening and diagnosing diabetes mellitus","volume":"93","author":"Saudek","year":"2008","journal-title":"J. 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