{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T20:54:42Z","timestamp":1768942482593,"version":"3.49.0"},"reference-count":13,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"}],"funder":[{"name":"Innovate UK Grant"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The feasibility of using a novel, non-invasive breath-based diagnostic test for detecting Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was evaluated in a real-world clinical setting. The study aimed to assess the device\u2019s performance, usability and integration into routine point-of-care pathways, while also obtaining preliminary diagnostic accuracy metrics to inform future validation studies. This was a cross-sectional study performed in a single National Health Service hospital. Participants in cohort A were recruited with prior knowledge of their PCR swab results. Cohort B were sequential participants in a prospective \u2018real-world\u2019 evaluation. 385 participants were recruited, with 214 participants achieving a suitable sample for analysis. Of 179 participants in cohort A, 60 (33.5%) had clinically suspected SARS-CoV-2 confirmed with a positive PCR swab, 31 (17.3%) had clinically suspected SARS-CoV-2, but a negative PCR swab, 22 (12.3%) were asymptomatic but with a positive PCR swab and 66 (36.9%) had a low clinical suspicion of SARS-CoV-2 and negative PCR swab. Across all participants with a suitable sample for analysis, the Exhalation Technology Limited (ETL) CoronaCheck\u00ae had a sensitivity of 99% and specificity of 96%. Cohen\u2019s\n                    <jats:italic>K<\/jats:italic>\n                    score confirmed an excellent agreement between a positive vs negative CoronaCheck outcome against a positive vs negative PCR result (\n                    <jats:italic>k<\/jats:italic>\n                    = 0.990, 99%, SE:0.10). The CoronaCheck demonstrated an excellent predictive value for a positive PCR result, with low variability (both cohorts: ROC = 0.98 (CI:94%\u2013100%)). Most participants (88%) reported the CoronaCheck was easy to use, highlighting its potential utility in clinical practice. This study demonstrates it is feasible to use exhaled breath condensate and the ETL CoronaCheck\u00ae device to detect SARS-CoV-2 in a rapid point-of-care test.\n                  <\/jats:p>","DOI":"10.1088\/1752-7163\/ae2f94","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T22:52:09Z","timestamp":1766184729000},"page":"016008","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A feasibility study using the ETL CoronaCheck\u00ae device to identify incident cases of SARS-CoV-2: FIND SARS-CoV-2"],"prefix":"10.1088","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6152-2107","authenticated-orcid":true,"given":"Lauren","family":"Fox","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9584-0621","authenticated-orcid":true,"given":"Sharon","family":"Glaysher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6242-4587","authenticated-orcid":true,"given":"Milan AJ","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4936-6903","authenticated-orcid":false,"given":"Jane","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6849-3962","authenticated-orcid":false,"given":"Jonathan C","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6413-2454","authenticated-orcid":false,"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0546-6734","authenticated-orcid":true,"given":"Rebecca","family":"Stores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-6114","authenticated-orcid":false,"given":"Anoop J","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-4719","authenticated-orcid":false,"given":"Thomas P","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"jbrae2f94bib1","article-title":"World Health Organization 2023 data.who.int, WHO Coronavirus (COVID-19) dashboard","author":"WHO","type":"web-resource"},{"key":"jbrae2f94bib2","doi-asserted-by":"publisher","first-page":"m3862","DOI":"10.1136\/bmj.m3862","type":"journal-article","article-title":"Virology, transmission, and pathogenesis of SARS-CoV-2","volume":"371","author":"Cevik","year":"2020","journal-title":"BMJ"},{"key":"jbrae2f94bib3","article-title":"Rapid evaluation of Lateral Flow Viral Antigen detection devices (LFDs) for mass community testing:","author":"Joint PHE Porton Down & University of Oxford SARS-CoV-2 LFD test development and validation cell","year":"2020","type":"web-resource"},{"key":"jbrae2f94bib4","article-title":"Antigen-detection in the diagnosis of SARS-CoV-2 infection using rapid immunoassays","author":"WHO","year":"2020","type":"web-resource"},{"key":"jbrae2f94bib5","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1136\/thoraxjnl-2020-215705","type":"journal-article","article-title":"Use of exhaled breath condensate (EBC) in the diagnosis of SARS-COV-2 (COVID-19)","volume":"76","author":"Ryan","year":"2021","journal-title":"Thorax"},{"key":"jbrae2f94bib6","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.4155\/bio-2020-0083","type":"journal-article","article-title":"Exhaled breath condensate as a potential specimen for diagnosing COVID-19","volume":"12","author":"Khoubnasabjafari","year":"2020","journal-title":"Bioanalysis"},{"key":"jbrae2f94bib7","doi-asserted-by":"publisher","first-page":"6411","DOI":"10.1007\/s00216-018-1259-4","type":"journal-article","article-title":"Non-volatile compounds in exhaled breath condensate: review of methodological aspects","volume":"410","author":"Rahimpour","year":"2018","journal-title":"Anal. 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Published by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2025-05-02","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-12-19","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-01-20","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}