{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:01:18Z","timestamp":1787590878639,"version":"build-2736575974"},"reference-count":41,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["88881.982471\/2024-01"],"award-info":[{"award-number":["88881.982471\/2024-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["305654\/2023\u20133"],"award-info":[{"award-number":["305654\/2023\u20133"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Halitosis, commonly known as bad breath, is a highly prevalent condition often associated with volatile sulfur compounds (VSCs) produced by oral anaerobic bacteria. While intraoral halitosis is the most frequent type, its psychosocial impact remains underexplored in terms of its correlation with objective diagnostic markers. This study investigated the association between VSC concentrations and halitosis-related quality of life using the Halitosis Associated Life-Quality Test (HALT). In this cross-sectional study, 40 adults self-reporting halitosis were assessed using OralChroma\u2122, a portable gas chromatograph that quantifies hydrogen sulfide, methyl mercaptan, and dimethyl sulfide. Breath samples were collected at baseline and after an L-cysteine oral rinse challenge. Participants completed the HALT questionnaire to assess emotional, social, and functional impacts. Statistical analyses included descriptive metrics, Pearson\u2019s correlation, and multiple linear regression. Model assumptions were tested for validity. At baseline, 25% of participants had VSC levels above diagnostic thresholds; after L-cysteine administration, this proportion increased to 87.5%, indicating the presence of latent halitosis. Methyl mercaptan concentration before the challenge showed a significant correlation with HALT scores (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.353;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.025) and was the only significant predictor in the final regression model (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    = 1.03;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.025;\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0.125). Elevated HALT scores were also observed in participants without clinically confirmed halitosis, suggesting that self-perception and emotional distress play a central role in patient experience. These findings highlight the relevance of combining objective VSC measurements with validated, condition-specific quality-of-life instruments to better understand and manage halitosis. Methyl mercaptan may serve as a biochemical marker of halitosis severity and also as a potential mediator of its psychosocial consequences.\n                  <\/jats:p>","DOI":"10.1088\/1752-7163\/ae3f4a","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:49:44Z","timestamp":1769726984000},"page":"016011","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Psychosocial burden of halitosis: association between volatile sulfur compounds and quality of life in adults"],"prefix":"10.1088","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3952-6002","authenticated-orcid":true,"given":"Mailon Cury","family":"Carneiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0549-1846","authenticated-orcid":false,"given":"Maria L\u00edvia Rodrigues","family":"de Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8361-3894","authenticated-orcid":false,"given":"Raquel D\u2019Aquino Garcia","family":"Caminha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4906-7698","authenticated-orcid":false,"given":"Marcelo","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0674-3759","authenticated-orcid":false,"given":"Paulo S\u00e9rgio da Silva","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"jbrae3f4abib1","doi-asserted-by":"publisher","first-page":"564","DOI":"10.3390\/medicina59030564","type":"journal-article","article-title":"Emotional and social impact of halitosis on adolescents and young adults: a systematic review","volume":"59","author":"Briceag","year":"2023","journal-title":"Medicina"},{"key":"jbrae3f4abib2","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.4314\/ahs.v20i4.62","type":"journal-article","article-title":"Self-reported halitosis and oral health related quality of life in adolescent students from a suburban community in Nigeria","volume":"20","author":"Alade","year":"2020","journal-title":"Afr. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2025-06-17","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-01-29","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-02-10","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}