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Breath Res."],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Exhaled breath containing volatile organic compounds (VOCs) can be analysed non-invasively and has potential applications in disease diagnosis. Previous high-field asymmetric waveform ion mobility spectrometry (FAIMS)-based breath studies have primarily used low-resolution FAIMS with ion current detection rather than mass spectrometry (MS). Here, atmospheric pressure chemical ionisation (APCI) was coupled with high-resolution FAIMS-MS for direct breath analysis. APCI-FAIMS-MS increased the number of detected breath features by &gt;200% compared with APCI-MS alone and consistently detected 60\u2013130 breath features per sample. Within-participant heatmap consistency was comparable across the four participants based on structural similarity index analysis. Exploratory principal component analysis showed participant-associated clustering of breath profiles. These results demonstrate that high-resolution FAIMS substantially enhances breath feature detection and provides an orthogonal separation dimension for untargeted breath profiling. Future studies involving larger cohorts and disease-specific populations will determine whether the increased breath feature coverage afforded by high-resolution FAIMS can improve VOC-based classification and diagnostic performance.<\/jats:p>","DOI":"10.1088\/1752-7163\/aeabcd","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:51:45Z","timestamp":1790203905000},"page":"046005","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["High-resolution FAIMS-mass spectrometry for breath analysis using atmospheric pressure chemical ionisation"],"prefix":"10.1088","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1464-7644","authenticated-orcid":false,"given":"J Diana","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chemistry, University of New South 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