{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:42:56Z","timestamp":1792568576754,"version":"4.5.0"},"reference-count":43,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"}],"funder":[{"name":"TRANSSCAN-2","award":["ERA-NETTRANSSCAN\/02.2018"],"award-info":[{"award-number":["ERA-NETTRANSSCAN\/02.2018"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Irritable bowel syndrome (IBS) is heterogenous disorder of gut-brain interaction, with a key role for the dysregulated host-gut microbiota interplay. IBS subtyping is based only on symptoms of bowel habits, reflecting limited insight into underlying biological mechanisms. This study aimed to define microbiota-based IBS phenotypes and to compare these to traditional stool-based subtyping. The study utilized data from the Maastricht IBS cohort. Gut microbiota composition was analysed using shotgun metagenomic sequencing. Faecal volatile organic compounds (VOCs) were measured by gas chromatography mass spectrometry. Dietary intake and gastrointestinal and mental health symptoms were assessed using a food frequency questionnaire, the Dutch Healthy Diet-15 index, the gastrointestinal symptom rating scale, and hospital anxiety and depression scores, respectively. Machine-learning approaches were applied to identify microbiota-based phenotypical clusters, which were compared with established Rome III subtypes, and associated with faecal VOCs, gastrointestinal symptom severity, diet and mental health. 178 IBS patients and 134 healthy controls were included. Gut microbiota composition distinguished IBS patients from healthy controls with an AUCROC 0 \u00b7 8. This discriminatory profile was not associated with Rome III subtypes, while statistically significant associations were found with faecal VOCs profiles (i.e.\n                    <jats:italic>R<\/jats:italic>\n                    = 0 \u00b7 67,\n                    <jats:italic>p<\/jats:italic>\n                    = 4 \u00b7 46e-4) and symptom severity scores of abdominal pain (\n                    <jats:italic>p<\/jats:italic>\n                    = 0 \u00b7 05), reflux (\n                    <jats:italic>p<\/jats:italic>\n                    = 0 \u00b7 03), diarrhoea (\n                    <jats:italic>p<\/jats:italic>\n                    = 0 \u00b7 01) and depression (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0 \u00b7 001). Dietary associations varied across clusters. These results suggest that gut microbiota profiling might provide a basis to define relevant IBS endotypes. Further exploration and validation efforts into this direction are needed using longitudinal studies to refine IBS patient stratification ultimately.\n                  <\/jats:p>","DOI":"10.1088\/1752-7163\/aeb043","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:49:28Z","timestamp":1791240568000},"page":"046009","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the presence of microbiota-based phenotypes in irritable bowel syndrome"],"prefix":"10.1088","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1953-0207","authenticated-orcid":true,"given":"Robert van","family":"Vorstenbosch","sequence":"first","affiliation":[{"name":"Maastricht University"},{"name":"NUTRIM, Institute of Nutrition & Translational Research in Metabolism, Maastricht University"},{"name":"Institute of Risk Assessment Sciences, Population Health Sciences, Utrecht University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8807-1624","authenticated-orcid":true,"given":"Ekaterina E","family":"Esenkova","sequence":"additional","affiliation":[{"name":"Maastricht University"},{"name":"NUTRIM, Institute of Nutrition & Translational Research in Metabolism, Maastricht University"},{"name":"Department of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz"},{"name":"German Center for Cardiovascular Research (DZHK)"},{"name":"Clinical Epidemiology and Systems Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy M A E","family":"Jonkers","sequence":"additional","affiliation":[{"name":"NUTRIM, Institute of Nutrition & Translational Research in Metabolism, Maastricht University"},{"name":"Maastricht University Medical Centre (MUMC+)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0664-7579","authenticated-orcid":true,"given":"Montserrat Elizalde","family":"Vilalta","sequence":"additional","affiliation":[{"name":"NUTRIM, Institute of Nutrition & Translational Research in Metabolism, Maastricht University"},{"name":"Maastricht University Medical Centre (MUMC+)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5427-8038","authenticated-orcid":true,"given":"Marlijne de","family":"Graaf","sequence":"additional","affiliation":[{"name":"NUTRIM, Institute of Nutrition & Translational Research in Metabolism, Maastricht University"},{"name":"Maastricht University Medical Centre (MUMC+)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Keszthelyi","sequence":"additional","affiliation":[{"name":"NUTRIM, Institute of Nutrition & Translational Research in Metabolism, Maastricht University"},{"name":"Maastricht University Medical Centre (MUMC+)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00eblle","family":"Pachen","sequence":"additional","affiliation":[{"name":"Maastricht University"},{"name":"NUTRIM, Institute of Nutrition & Translational Research in Metabolism, Maastricht University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8111-8198","authenticated-orcid":true,"given":"Frederik-Jan van","family":"Schooten","sequence":"additional","affiliation":[{"name":"Maastricht University"},{"name":"NUTRIM, Institute of Nutrition & Translational Research in Metabolism, Maastricht University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5211-0381","authenticated-orcid":true,"given":"Zlatan","family":"Mujagic","sequence":"additional","affiliation":[{"name":"NUTRIM, Institute of Nutrition & Translational Research in Metabolism, Maastricht University"},{"name":"Maastricht University Medical Centre (MUMC+)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1412-4544","authenticated-orcid":true,"given":"Agnieszka","family":"Smolinska","sequence":"additional","affiliation":[{"name":"Maastricht University"},{"name":"NUTRIM, Institute of Nutrition & Translational Research in Metabolism, Maastricht University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"jbraeb043bib1","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/S2468-1253(20)30217-X","type":"journal-article","article-title":"Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis","volume":"5","author":"Oka","year":"2020","journal-title":"Lancet Gastroenterol. 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