{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:39:34Z","timestamp":1792503574619,"version":"4.5.0"},"reference-count":0,"publisher":"IOP Publishing","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Exhaled breath analysis is a non-invasive approach for assessing physiological alterations in obstructive sleep apnea (OSA). This study evaluated overnight changes in exhaled CO\u2082, O\u2082, and N\u2082O concentrations and their associations with OSA severity and polysomnographic parameters.&amp;#xD;Methods: In this prospective observational study, 62 adults undergoing diagnostic overnight polysomnography were enrolled and classified as having no OSA (n = 21), mild-to-moderate OSA (n = 21), or severe OSA (n = 20) according to the apnea\u2013hypopnea index. Exhaled CO\u2082, O\u2082, and N\u2082O concentrations were measured immediately before and after overnight polysomnography under standardized conditions.&amp;#xD;Results: Morning exhaled N\u2082O concentrations were significantly higher in patients with severe OSA than in the other groups (p = 0.001). Overnight changes in exhaled CO\u2082 (\u0394CO\u2082), N\u2082O (\u0394N\u2082O), and O\u2082 (\u0394O\u2082) differed significantly according to OSA severity (all p &lt; 0.001). Compared with the no OSA group, patients with OSA exhibited greater overnight increases in exhaled CO\u2082 and N\u2082O concentrations together with greater decreases in exhaled O\u2082 concentrations. Overnight \u0394N\u2082O and \u0394O\u2082 showed strong correlations with AHI (\u03c1 = \u22120.760 and 0.912, respectively; both p &lt; 0.001) and ODI (\u03c1 = \u22120.713 and 0.913, respectively; both p &lt; 0.001).&amp;#xD;Conclusion: Patients with OSA exhibited more pronounced overnight alterations in exhaled gas composition, particularly greater changes in exhaled O\u2082 and N\u2082O concentrations. These findings suggest that dynamic overnight exhaled gas changes may reflect physiological alterations associated with OSA severity and warrant further validation in larger prospective studies.&amp;#xD;<\/jats:p>","DOI":"10.1088\/1752-7163\/aeb686","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:48:28Z","timestamp":1792500508000},"source":"Crossref","is-referenced-by-count":0,"title":["Overnight changes in exhaled carbon dioxide, oxygen, and nitrous oxide in obstructive sleep apnea: associations with disease severity and polysomnographic findings"],"prefix":"10.1088","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-7982","authenticated-orcid":false,"given":"Mustafa Bu\u011fra Bu\u011fra","family":"Co\u015fkuner","sequence":"first","affiliation":[{"name":"Aksaray Universitesi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6048-1462","authenticated-orcid":false,"given":"Bu\u011fra","family":"Kerget","sequence":"additional","affiliation":[{"name":"Aksaray Universitesi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"S\u00f6nmez","sequence":"additional","affiliation":[{"name":"Aksaray Universitesi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0786-5077","authenticated-orcid":false,"given":"Huseyin","family":"Erdal","sequence":"additional","affiliation":[{"name":"Aksaray Universitesi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4512-8783","authenticated-orcid":false,"given":"\u0130smail","family":"Bayrakl\u0131","sequence":"additional","affiliation":[{"name":"Aksaray Universitesi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,10,20]]},"container-title":["Journal of Breath Research"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aeb686","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aeb686\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aeb686\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aeb686\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:48:28Z","timestamp":1792500508000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1752-7163\/aeb686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1088\/1752-7163\/aeb686","relation":{},"ISSN":["1752-7155","1752-7163"],"issn-type":[{"value":"1752-7155","type":"print"},{"value":"1752-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,20]]}}}