{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T13:06:39Z","timestamp":1779541599184,"version":"3.53.1"},"reference-count":55,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"tdm","delay-in-days":9,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["NRF-2017K2A9A2A08000171"],"award-info":[{"award-number":["NRF-2017K2A9A2A08000171"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biofabrication"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In this study, we developed a new system enabling rapid delivery of a multi-layered cell sheet by combining layer-by-layer (LBL) coating of a cell membrane and surface engineered thermally expandable hydrogel. Human dermal fibroblasts were LBL-coated with fibronectin (FN) and gelatin to form a multi-layered cell sheet in a single seeding step via spontaneous 3D cell\u2013cell interactions. FN was covalently immobilized onto the surface of a Tetronic\n                    <jats:sup>\u00ae<\/jats:sup>\n                    \u2014based hydrogel at two different concentrations (1 and 5\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) for stable adhesion of the multi-layered cell sheet, followed by polydopamine coating. In both conditions, a multi-layered cell sheet was stably formed. Then, the cell sheet on the hydrogel modified with 1\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    FN rapidly detached (&gt;90% efficiency) in response to the expansion of the hydrogel when temperature changed from 37 \u00b0C to 4 \u00b0C, while the other group had a reduced detachment due to excessive cell\u2013hydrogel interaction. The multi-layered cell sheet was evident in cell\u2013extracellular matrix and cell\u2013cell junction formation, and bFGF was continuously secreted over 7 days of\n                    <jats:italic>in vitro<\/jats:italic>\n                    culture. The multi-layered transplanted to the mouse subcutaneous tissue also exhibited evidence of vascular ingrowth, which collectively suggest that the delivery system maintaining cellular functions is applicable for regenerative medicine.\n                  <\/jats:p>","DOI":"10.1088\/1758-5090\/aa9d43","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T10:49:53Z","timestamp":1511779793000},"page":"025001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["One-step delivery of a functional multi-layered cell sheet using a thermally expandable hydrogel with controlled presentation of cell adhesive proteins"],"prefix":"10.1088","volume":"10","author":[{"given":"Yu Bin","family":"Lee","sequence":"first","affiliation":[{"name":"Hanyang University"},{"name":"Hanyang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong-yup","family":"Lee","sequence":"additional","affiliation":[{"name":"Hanyang University"},{"name":"Hanyang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayeon","family":"Byun","sequence":"additional","affiliation":[{"name":"Hanyang University"},{"name":"Hanyang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taufiq","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Hanyang University"},{"name":"Hanyang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Akashi","sequence":"additional","affiliation":[{"name":"Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiya","family":"Matsusaki","sequence":"additional","affiliation":[{"name":"Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9036-155X","authenticated-orcid":false,"given":"Heungsoo","family":"Shin","sequence":"additional","affiliation":[{"name":"Hanyang University"},{"name":"Hanyang University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"bfaa9d43bib1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/S1369-7021(04)00234-2","type":"journal-article","article-title":"Cell sheet engineering","volume":"7","author":"Yamato","year":"2004","journal-title":"Mater. Today"},{"key":"bfaa9d43bib2","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.jconrel.2014.05.024","type":"journal-article","article-title":"Cell sheet approach for tissue engineering and regenerative medicine","volume":"190","author":"Matsuura","year":"2014","journal-title":"J. Control. Release"},{"key":"bfaa9d43bib3","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.tibtech.2015.02.003","type":"journal-article","article-title":"Multiscale assembly for tissue engineering and regenerative medicine","volume":"33","author":"Guven","year":"2015","journal-title":"Trends Biotechnol."},{"key":"bfaa9d43bib4","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1056\/NEJMoa040455","type":"journal-article","article-title":"Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium","volume":"351","author":"Nishida","year":"2004","journal-title":"New Engl. J. Med."},{"key":"bfaa9d43bib5","doi-asserted-by":"publisher","first-page":"6716","DOI":"10.1038\/srep06716","type":"journal-article","article-title":"Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration","volume":"4","author":"Masumoto","year":"2014","journal-title":"Sci. Rep."},{"key":"bfaa9d43bib6","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.jhep.2016.01.004","type":"journal-article","article-title":"Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure","volume":"64","author":"Nagamoto","year":"2016","journal-title":"J. Hepatology"},{"key":"bfaa9d43bib7","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1136\/gut.2005.088518","type":"journal-article","article-title":"Treatment of oesophageal ulcerations using endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets in a canine model","volume":"55","author":"Ohki","year":"2006","journal-title":"Gut"},{"key":"bfaa9d43bib8","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1038\/ncomms2406","type":"journal-article","article-title":"In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels","volume":"4","author":"Sekine","year":"2013","journal-title":"Nat. Commun."},{"key":"bfaa9d43bib9","doi-asserted-by":"publisher","first-page":"16842","DOI":"10.1038\/srep16842","type":"journal-article","article-title":"Efficient long-term survival of cell grafts after myocardial infarction with thick viable cardiac tissue entirely from pluripotent stem cells","volume":"5","author":"Matsuo","year":"2015","journal-title":"Sci. Rep."},{"key":"bfaa9d43bib10","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/301279","type":"journal-article","article-title":"Preparation of three-dimensional vascularized MSC cell sheet constructs for tissue regeneration","volume":"2014","author":"Ren","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"bfaa9d43bib11","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1038\/nprot.2012.027","type":"journal-article","article-title":"Fabrication of functional three-dimensional tissues by stacking cell sheets in vitro","volume":"7","author":"Haraguchi","year":"2012","journal-title":"Nat. Protocols"},{"key":"bfaa9d43bib12","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.3390\/polym4031478","type":"journal-article","article-title":"Temperature-responsive polymer modified surface for cell sheet engineering","volume":"4","author":"Tang","year":"2012","journal-title":"Polymers"},{"key":"bfaa9d43bib13","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1002\/jbm.b.33148","type":"journal-article","article-title":"Facile cell sheet manipulation and transplantation by using in situ gelation method","volume":"102","author":"Akimoto","year":"2014","journal-title":"J. Biomed. Mater. Res. B"},{"key":"bfaa9d43bib14","doi-asserted-by":"publisher","first-page":"4689","DOI":"10.1002\/anie.200701089","type":"journal-article","article-title":"Fabrication of cellular multilayers with nanometer-sized extracellular matrix films","volume":"46","author":"Matsusaki","year":"2007","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"bfaa9d43bib15","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1246\/bcsj.20110194","type":"journal-article","article-title":"Development of three-dimensional tissue models based on hierarchical cell manipulation using nanofilms","volume":"85","author":"Matsusaki","year":"2012","journal-title":"Bull. Chem. Soc. Japan"},{"key":"bfaa9d43bib16","doi-asserted-by":"publisher","first-page":"3506","DOI":"10.1002\/adma.201101787","type":"journal-article","article-title":"Rapid construction of three-dimensional multilayered tissues with endothelial tube networks by the cell-accumulation technique","volume":"23","author":"Nishiguchi","year":"2011","journal-title":"Adv. Mater."},{"key":"bfaa9d43bib17","doi-asserted-by":"publisher","first-page":"7557","DOI":"10.1002\/anie.201008204","type":"journal-article","article-title":"Quantitative 3D analysis of nitric oxide diffusion in a 3D artery model using sensor particles","volume":"50","author":"Matsusaki","year":"2011","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"bfaa9d43bib18","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1002\/adhm.201500065","type":"journal-article","article-title":"Dynamic nano-interfaces enable harvesting of functional 3D-engineered tissues","volume":"4","author":"Nishiguchi","year":"2015","journal-title":"Adv. Healthcare Mater."},{"key":"bfaa9d43bib19","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.biomaterials.2015.03.016","type":"journal-article","article-title":"Transfer stamping of human mesenchymal stem cell patches using thermally expandable hydrogels with tunable cell-adhesive properties","volume":"54","author":"Jun","year":"2015","journal-title":"Biomaterials"},{"key":"bfaa9d43bib20","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1002\/adhm.201600210","type":"journal-article","article-title":"Facile cell sheet harvest and translocation mediated by a thermally expandable hydrogel with controlled cell adhesion","volume":"5","author":"Lee","year":"2016","journal-title":"Adv. Healthcare Mater."},{"key":"bfaa9d43bib21","doi-asserted-by":"publisher","first-page":"6012","DOI":"10.1039\/C6TB01057A","type":"journal-article","article-title":"Mussel adhesive protein inspired coatings on temperature-responsive hydrogels for cell sheet engineering","volume":"4","author":"Lee","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"bfaa9d43bib22","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1242\/bio.017632","type":"journal-article","article-title":"Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells","volume":"5","author":"Robinson","year":"2016","journal-title":"Biol. Open"},{"key":"bfaa9d43bib23","doi-asserted-by":"publisher","first-page":"4916","DOI":"10.1039\/c1nr10969c","type":"journal-article","article-title":"Polydopamine\u2014a nature-inspired polymer coating for biomedical science","volume":"3","author":"Lynge","year":"2011","journal-title":"Nanoscale"},{"key":"bfaa9d43bib24","doi-asserted-by":"publisher","first-page":"5057","DOI":"10.1021\/cr400407a","type":"journal-article","article-title":"Polydopamine and its derivative materials: synthesis and promising applications in energy, environmental, and biomedical fields","volume":"114","author":"Liu","year":"2014","journal-title":"Chem. Rev."},{"key":"bfaa9d43bib25","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.1021\/acs.biomac.5b00852","type":"journal-article","article-title":"Materials from mussel-inspired chemistry for cell and tissue engineering applications","volume":"16","author":"Perikamana","year":"2015","journal-title":"Biomacromolecules"},{"key":"bfaa9d43bib26","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1021\/bm9012875","type":"journal-article","article-title":"In situ forming hydrogels based on tyramine conjugated 4-Arm-PPO-PEO via enzymatic oxidative reaction","volume":"11","author":"Park","year":"2010","journal-title":"Biomacromolecules"},{"key":"bfaa9d43bib27","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/nnano.2007.380","type":"journal-article","article-title":"Layer-by-layer assembled charge-trap memory devices with adjustable electronic properties","volume":"2","author":"Lee","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"bfaa9d43bib28","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/pj.2014.20","type":"journal-article","article-title":"Control of extracellular microenvironments using polymer\/protein nanofilms for the development of three-dimensional human tissue chips","volume":"46","author":"Matsusaki","year":"2014","journal-title":"Polym. J."},{"key":"bfaa9d43bib29","doi-asserted-by":"publisher","first-page":"7362","DOI":"10.1021\/la303459v","type":"journal-article","article-title":"Effectiveness of nanometer-sized extracellular matrix layer-by-layer assembled films for a cell membrane coating protecting cells from physical stress","volume":"29","author":"Matsuzawa","year":"2013","journal-title":"Langmuir"},{"key":"bfaa9d43bib30","doi-asserted-by":"publisher","first-page":"5670","DOI":"10.1021\/la903738n","type":"journal-article","article-title":"Control of cell surface and functions by layer-by-layer nanofilms","volume":"26","author":"Kadowaki","year":"2010","journal-title":"Langmuir"},{"key":"bfaa9d43bib31","doi-asserted-by":"publisher","first-page":"8343","DOI":"10.1016\/j.biomaterials.2012.08.011","type":"journal-article","article-title":"Polydopamine-mediated immobilization of multiple bioactive molecules for the development of functional vascular graft materials","volume":"33","author":"Lee","year":"2012","journal-title":"Biomaterials"},{"key":"bfaa9d43bib32","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.msec.2016.03.001","type":"journal-article","article-title":"Anticoagulation and endothelial cell behaviors of heparin-loaded graphene oxide coating on titanium surface","volume":"63","author":"Pan","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"bfaa9d43bib33","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1155\/2010\/296094","type":"journal-article","article-title":"Surface engineered polymeric biomaterials with improved biocontact properties","volume":"2010","author":"Vladkova","year":"2010","journal-title":"Int. J. Polym. Sci."},{"key":"bfaa9d43bib34","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1021\/bm200083n","type":"journal-article","article-title":"Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review","volume":"12","author":"Van Vlierberghe","year":"2011","journal-title":"Biomacromolecules"},{"key":"bfaa9d43bib35","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.3390\/ma3031746","type":"journal-article","article-title":"Injectable, biodegradable hydrogels for tissue engineering applications","volume":"3","author":"Tan","year":"2010","journal-title":"Materials"},{"key":"bfaa9d43bib36","doi-asserted-by":"publisher","first-page":"8846","DOI":"10.1021\/ma035166+","type":"journal-article","article-title":"Surface-modified hydrogels for chemoselective bioconjugation","volume":"36","author":"Plunkett","year":"2003","journal-title":"Macromolecules"},{"key":"bfaa9d43bib37","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3390\/polym3010114","type":"journal-article","article-title":"Gelatin functionalization of biomaterial surfaces: strategies for immobilization and visualization","volume":"3","author":"Van Vlierberghe","year":"2011","journal-title":"Polymers"},{"key":"bfaa9d43bib38","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1002\/jbm.b.30131","type":"journal-article","article-title":"Corneal epithelial cell growth over tethered-protein\/peptide surface-modified hydrogels","volume":"72B","author":"Jacob","year":"2005","journal-title":"J. Biomed. Mater. Res. B"},{"key":"bfaa9d43bib39","doi-asserted-by":"publisher","first-page":"14443","DOI":"10.1002\/anie.201408454","type":"journal-article","article-title":"Cytoprotective alginate\/polydopamine core\/shell microcapsules in microbial encapsulation","volume":"53","author":"Kim","year":"2014","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"bfaa9d43bib40","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1002\/adhm.201670096","type":"journal-article","article-title":"Facile cell sheet harvest and translocation mediated by a thermally expandable hydrogel with controlled cell adhesion","volume":"5","author":"Lee","year":"2016","journal-title":"Adv. Healthcare Mater."},{"key":"bfaa9d43bib41","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.colsurfb.2012.02.026","type":"journal-article","article-title":"Low fibronectin concentration overcompensates for reduced initial fibroblasts adhesion to a nanoscale topography: single-cell force spectroscopy","volume":"95","author":"Elter","year":"2012","journal-title":"Colloids Surf. B"},{"key":"bfaa9d43bib42","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.1242\/jcs.023820","type":"journal-article","article-title":"The extracellular matrix at a glance","volume":"123","author":"Frantz","year":"2010","journal-title":"J. Cell Sci."},{"key":"bfaa9d43bib43","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.cardiores.2003.11.013","type":"journal-article","article-title":"Gap junctions and the connexin protein family","volume":"62","author":"Sohl","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"bfaa9d43bib44","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/nrc2780","type":"journal-article","article-title":"Fibroblast growth factor signalling: from development to cancer","volume":"10","author":"Turner","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"bfaa9d43bib45","doi-asserted-by":"publisher","first-page":"5869","DOI":"10.1002\/anie.201411386","type":"journal-article","article-title":"Photothermally induced local dissociation of collagens for harvesting of cell sheets","volume":"54","author":"Kim","year":"2015","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"bfaa9d43bib46","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1089\/ten.tea.2015.0124","type":"journal-article","article-title":"Delivery of a cell patch of cocultured endothelial cells and smooth muscle cells using thermoresponsive hydrogels for enhanced angiogenesis","volume":"22","author":"Bak","year":"2016","journal-title":"Tissue Eng. A"},{"key":"bfaa9d43bib47","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.biomaterials.2013.09.104","type":"journal-article","article-title":"Expression profiles of angiogenesis-related proteins in prevascular three-dimensional tissues using cell-sheet engineering","volume":"35","author":"Sasagawa","year":"2014","journal-title":"Biomaterials"},{"key":"bfaa9d43bib48","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1038\/srep01418","type":"journal-article","article-title":"iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis","volume":"3","author":"Kito","year":"2013","journal-title":"Sci. Rep."},{"key":"bfaa9d43bib49","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1007\/s00595-013-0528-2","type":"journal-article","article-title":"Impact of cardiac stem cell sheet transplantation on myocardial infarction","volume":"43","author":"Alshammary","year":"2013","journal-title":"Surg. Today"},{"key":"bfaa9d43bib50","doi-asserted-by":"publisher","first-page":"4781","DOI":"10.1038\/srep04781","type":"journal-article","article-title":"Induction of functional tissue-engineered skeletal muscle constructs by defined electrical stimulation","volume":"4","author":"Ito","year":"2014","journal-title":"Sci. Rep."},{"key":"bfaa9d43bib51","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1038\/srep01316","type":"journal-article","article-title":"In vitro engineering of vascularized tissue surrogates","volume":"3","author":"Sakaguchi","year":"2013","journal-title":"Sci. Rep."},{"key":"bfaa9d43bib52","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1089\/ten.2006.12.1553","type":"journal-article","article-title":"Polyelectrolyte nano-scaffolds for the design of layered cellular architectures","volume":"12","author":"Rajagopalan","year":"2006","journal-title":"Tissue Eng."},{"key":"bfaa9d43bib53","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1093\/jb\/mvp019","type":"journal-article","article-title":"Maturation of the extracellular matrix and cell adhesion molecules in layered co-cultures of HepG2 and endothelial cells","volume":"145","author":"Ohno","year":"2009","journal-title":"J. Biochem."},{"key":"bfaa9d43bib54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137494","type":"journal-article","article-title":"Time course of cell sheet adhesion to porcine heart tissue after transplantation","volume":"10","author":"Chang","year":"2015","journal-title":"PLoS One"},{"key":"bfaa9d43bib55","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/mt.2014.225","type":"journal-article","article-title":"Cell-sheet therapy with omentopexy promotes arteriogenesis and improves coronary circulation physiology in failing heart","volume":"23","author":"Kainuma","year":"2015","journal-title":"Mol. Ther."}],"container-title":["Biofabrication"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/aa9d43","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/aa9d43\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/aa9d43\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/aa9d43","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/aa9d43","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/aa9d43\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/aa9d43\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/aa9d43\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/aa9d43\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/aa9d43\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/aa9d43","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/aa9d43\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T12:31:59Z","timestamp":1779539519000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/aa9d43"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":55,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,1,10]]},"published-print":{"date-parts":[[2018,1,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1758-5090\/aa9d43","relation":{},"ISSN":["1758-5082","1758-5090"],"issn-type":[{"value":"1758-5082","type":"print"},{"value":"1758-5090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,1]]},"assertion":[{"value":"One-step delivery of a functional multi-layered cell sheet using a thermally expandable hydrogel with controlled presentation of cell adhesive proteins","name":"article_title","label":"Article Title"},{"value":"Biofabrication","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2018 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2017-04-18","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-11-27","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2018-01-10","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}