{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:16:27Z","timestamp":1792804587186,"version":"4.5.0"},"reference-count":58,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biofabrication"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We used 3D cell printing to emulate an airway coupled with a naturally-derived blood vessel network\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Decellularized extracellular matrix bioink derived from porcine tracheal mucosa (tmdECM) was used to encapsulate and print endothelial cells and fibroblasts within a designated polycarprolactone (PCL) frame. Providing a niche that emulates conditions\n                    <jats:italic>in vivo<\/jats:italic>\n                    , tmdECM gradually drives endothelial re-orientation, which leads to the formation of a lumen and blood vessel network. A fully-differentiated\n                    <jats:italic>in vitro<\/jats:italic>\n                    airway model was assembled with the printed vascular platform, and collectively reproduced a functional interface between the airway epithelium and the vascular network. The model presented respiratory symptoms including asthmatic airway inflammation and allergen-induced asthma exacerbation in physiological context. Because of the adaptable and automated nature of direct 3D cell printing, we expect that this will have relevance\n                    <jats:italic>in vivo<\/jats:italic>\n                    and high reproducibility for production of high-content platforms for preclinical trials in biomedical research.\n                  <\/jats:p>","DOI":"10.1088\/1758-5090\/aae545","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T05:30:15Z","timestamp":1538371815000},"page":"015002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":135,"title":["Development of a functional airway-on-a-chip by 3D cell printing"],"prefix":"10.1088","volume":"11","author":[{"given":"Ju Young","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunryul","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byungjun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Heon","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjun","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suryong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Yun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5334-5238","authenticated-orcid":false,"given":"Noo Li","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5869-4330","authenticated-orcid":false,"given":"Dong-Woo","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"bfaae545bib1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1745-6673-1-11","type":"journal-article","article-title":"Chronic obstructive pulmonary disease (COPD) and occupational exposures","volume":"1","author":"Boschetto","year":"2006","journal-title":"J. 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