{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:38:13Z","timestamp":1793655493701,"version":"4.5.1"},"reference-count":65,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003654","name":"Korea Environmental Industry and Technology Institute","doi-asserted-by":"crossref","award":["RE202001059"],"award-info":[{"award-number":["RE202001059"]}],"id":[{"id":"10.13039\/501100003654","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["(NRF-2018R1A2A3074613"],"award-info":[{"award-number":["(NRF-2018R1A2A3074613"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biofabrication"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Conventional 2D or even 3D\n                    <jats:italic>in vitro<\/jats:italic>\n                    culture models for human reproductive organs cannot properly recapitulate the bidirectional endocrine crosstalk between the uterine endometrium and the ovary. This crosstalk is essential for maintaining the various physiological features and functions of each tissue. Moreover, most\n                    <jats:italic>in vitro<\/jats:italic>\n                    models for the female reproductive tract also fail to mimic its multicellular structure. We therefore developed a novel \u2018dual reproductive organ on a chip\u2019 that reflects the bidirectional endocrine cross-talk and the complex multicellular structures by integrating various cellular components of both the human uterine endometrium and the ovary with several biodegradable natural polymers. Indeed, the bidirectional endocrine crosstalk between these two tissues is achieved through media sharing between channels, and it can markedly improve the viability of loaded cells within each chamber of the chip platform. In addition, we also identified a reliable reproductive toxicity marker, SERPINB2, which is significantly increased in response to various toxic exposures in both endometrial and ovarian follicular cells. Based on these findings, we next established a SERPINB2 luciferase reporter system that was specifically designed for detecting and quantifying the toxicity of certain substances. By introducing this SERPINB2 luciferase reporter system into the loaded cells within the chip platform, we ultimately developed an effective \u2018dual reproductive organ-on-chip\u2019 that was successfully used to predict the reproductive toxicity of various hazardous materials.\n                  <\/jats:p>","DOI":"10.1088\/1758-5090\/abbd29","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T18:37:55Z","timestamp":1601491075000},"page":"015001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":47,"title":["Development of a novel dual reproductive organ on a chip: recapitulating bidirectional endocrine crosstalk between the uterine endometrium and the ovary"],"prefix":"10.1088","volume":"13","author":[{"given":"Se-Ra","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Rim","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4245-9381","authenticated-orcid":false,"given":"Jin Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4917-0177","authenticated-orcid":false,"given":"Chan Hum","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook-Joon","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Joo","family":"Chon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3267-0127","authenticated-orcid":false,"given":"In-Sun","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"bfabbd29bib1","doi-asserted-by":"publisher","first-page":"3822","DOI":"10.3390\/ijms20153822","type":"journal-article","article-title":"Progesterone and estrogen signaling in the endometrium: what goes wrong in endometriosis?","volume":"20","author":"Marquardt","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"bfabbd29bib2","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1038\/nm.3012","type":"journal-article","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat. Med."},{"key":"bfabbd29bib3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40104-018-0259-8","type":"journal-article","article-title":"Endometrial response to conceptus-derived estrogen and interleukin-1beta at the time of implantation in pigs","volume":"9","author":"Ka","year":"2018","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"bfabbd29bib4","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/208103","type":"journal-article","article-title":"Interleukins affect equine endometrial cell function: modulatory action of ovarian steroids","volume":"2014","author":"Szostek","year":"2014","journal-title":"Mediators Inflammation"},{"key":"bfabbd29bib5","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13048-014-0102-6","type":"journal-article","article-title":"Ultrastructural changes in oocytes during folliculogenesis in domestic mammals","volume":"7","author":"Paulini","year":"2014","journal-title":"J. Ovarian Res."},{"key":"bfabbd29bib6","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1210\/en.2005-0880","type":"journal-article","article-title":"Molecular cloning and spatiotemporal expression of prostaglandin F synthase and microsomal prostaglandin E synthase-1 in porcine endometrium","volume":"147","author":"Waclawik","year":"2006","journal-title":"Endocrinology"},{"key":"bfabbd29bib7","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1677\/JOE-07-0155","type":"journal-article","article-title":"Differential expression of prostaglandin (PG) synthesis enzymes in conceptus during peri-implantation period and endometrial expression of carbonyl reductase\/PG 9-ketoreductase in the pig","volume":"194","author":"Waclawik","year":"2007","journal-title":"J. Endocrinol."},{"key":"bfabbd29bib8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12958-018-0359-5","type":"journal-article","article-title":"Prostaglandin E2 involvement in mammalian female fertility: ovulation, fertilization, embryo development and early implantation","volume":"16","author":"Niringiyumukiza","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"bfabbd29bib9","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s10735-013-9501-z","type":"journal-article","article-title":"Expression and regulation of Runx3 in mouse uterus during the peri-implantation period","volume":"44","author":"Bai","year":"2013","journal-title":"J. Mol. Histol."},{"key":"bfabbd29bib10","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1093\/molehr\/gat031","type":"journal-article","article-title":"Uterine glands: development, function and experimental model systems","volume":"19","author":"Cooke","year":"2013","journal-title":"Mol. Hum. Reprod."},{"key":"bfabbd29bib11","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1186\/1471-2105-8-S7-S4","type":"journal-article","article-title":"Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats","volume":"8","author":"Mei","year":"2007","journal-title":"BMC Bioinform."},{"key":"bfabbd29bib12","doi-asserted-by":"publisher","first-page":"5 32 1","DOI":"10.1002\/cpns.27","type":"journal-article","article-title":"Quantitative high-throughput screening using a coincidence reporter biocircuit","volume":"79","author":"Schuck","year":"2017","journal-title":"Curr. Protoc. Neurosci."},{"key":"bfabbd29bib13","doi-asserted-by":"publisher","first-page":"1087-100","DOI":"10.1016\/j.ymthe.2019.03.010","type":"journal-article","article-title":"Sonic hedgehog, a novel endogenous damage signal, activates multiple beneficial functions of human endometrial stem cells","volume":"27","author":"Park","year":"2019","journal-title":"Mol. Ther."},{"key":"bfabbd29bib14","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1210\/jc.2011-1229","type":"journal-article","article-title":"Gonadotropin-releasing hormone-I or -II interacts with IGF-I\/Akt but not connexin 43 in human granulosa cell apoptosis","volume":"97","author":"Hong","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"bfabbd29bib15","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0303-7207(96)03835-X","type":"journal-article","article-title":"Long-term growth and steroidogenic potential of human granulosa-lutein cells immortalized with SV40 large T antigen","volume":"120","author":"Lie","year":"1996","journal-title":"Mol. Cell. Endocrinol."},{"key":"bfabbd29bib16","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/sj.onc.1205014","type":"journal-article","article-title":"Comparison of human mammary epithelial cells immortalized by simian virus 40 T-Antigen or by the telomerase catalytic subunit","volume":"21","author":"Toouli","year":"2002","journal-title":"Oncogene"},{"key":"bfabbd29bib17","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1038\/s41467-018-03759-y","type":"journal-article","article-title":"Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing","volume":"9","author":"Kim","year":"2018","journal-title":"Nat. Commun."},{"key":"bfabbd29bib18","doi-asserted-by":"publisher","DOI":"10.1038\/srep22966","type":"journal-article","article-title":"The Wnt\/beta-catenin signaling\/Id2 cascade mediates the effects of hypoxia on the hierarchy of colorectal-cancer stem cells","volume":"6","author":"Dong","year":"2016","journal-title":"Sci. Rep."},{"key":"bfabbd29bib19","doi-asserted-by":"publisher","first-page":"D562","DOI":"10.1093\/nar\/gki022","type":"journal-article","article-title":"NCBI GEO: mining millions of expression profiles\u2013database and tools","volume":"33","author":"Barrett","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"bfabbd29bib20","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","type":"journal-article","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"bfabbd29bib21","first-page":"175","type":"journal-article","article-title":"Mining microarray data at NCBI\u2019s gene expression omnibus (GEO)*","volume":"338","author":"Barrett","year":"2006","journal-title":"Methods Mol. Biol."},{"key":"bfabbd29bib22","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.bbrc.2012.07.120","type":"journal-article","article-title":"Inhibition of Wnt1 expression reduces the enrichment of cancer stem cells in a mouse model of breast cancer","volume":"425","author":"Choi","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"bfabbd29bib23","doi-asserted-by":"publisher","first-page":"8624","DOI":"10.1038\/s41598-017-09201-5","type":"journal-article","article-title":"Precise stacking of decellularized extracellular matrix based 3D cell-laden constructs by a 3D cell printing system equipped with heating modules","volume":"7","author":"Ahn","year":"2017","journal-title":"Sci. Rep."},{"key":"bfabbd29bib24","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/8\/3\/035020","type":"journal-article","article-title":"Effect of bioink properties on printability and cell viability for 3D bioplotting of embryonic stem cells","volume":"8","author":"Ouyang","year":"2016","journal-title":"Biofabrication"},{"key":"bfabbd29bib25","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1177\/1933719114537715","type":"journal-article","article-title":"Uterine infusion with bone marrow mesenchymal stem cells improves endometrium thickness in a rat model of thin endometrium","volume":"22","author":"Zhao","year":"2019","journal-title":"Reprod. Sci."},{"key":"bfabbd29bib26","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13244-020-0841-4","type":"journal-article","article-title":"Assessment of early damage of endometrium after artificial abortion by shear wave elastography","volume":"11","author":"Jiao","year":"2020","journal-title":"Insights Imaging"},{"key":"bfabbd29bib27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13630-015-0020-2","type":"journal-article","article-title":"Culture and detection of primary cilia in endothelial cell models","volume":"4","author":"Lim","year":"2015","journal-title":"Cilia"},{"key":"bfabbd29bib28","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.mce.2009.09.003","type":"journal-article","article-title":"Hormones in synergy: regulation of the pituitary gonadotropin genes","volume":"314","author":"Thackray","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"bfabbd29bib29","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1095\/biolreprod.106.051540","type":"journal-article","article-title":"Sex steroids are involved in the regulation of gonadotropin-releasing hormone and dopamine D2 receptors in female tilapia pituitary","volume":"75","author":"Levavi-Sivan","year":"2006","journal-title":"Biol. Reprod."},{"key":"bfabbd29bib30","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1210\/en.2013-2096","type":"journal-article","article-title":"Prostaglandin E2 (EP) receptors mediate PGE2-specific events in ovulation and luteinization within primate ovarian follicles","volume":"155","author":"Kim","year":"2014","journal-title":"Endocrinology"},{"key":"bfabbd29bib31","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/s41419-018-0748-x","type":"journal-article","article-title":"SERPINB2 is a novel indicator of stem cell toxicity","volume":"9","author":"Lee","year":"2018","journal-title":"Cell Death Dis."},{"key":"bfabbd29bib32","doi-asserted-by":"publisher","first-page":"499","DOI":"10.3390\/cancers11040499","type":"journal-article","article-title":"SERPINB2 is a novel indicator of cancer stem cell tumorigenicity in multiple cancer types","volume":"11","author":"Lee","year":"2019","journal-title":"Cancers"},{"key":"bfabbd29bib33","first-page":"6999","type":"journal-article","article-title":"Three-dimensional cell culture: A powerful tool in tumor research and drug discovery","volume":"14","author":"Lv","year":"2017","journal-title":"Oncol. Lett."},{"key":"bfabbd29bib34","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1089\/adt.2014.573","type":"journal-article","article-title":"Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors","volume":"12","author":"Edmondson","year":"2014","journal-title":"Assay Drug Dev. Technol."},{"key":"bfabbd29bib35","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1517\/17460441.2012.708334","type":"journal-article","article-title":"The multicellular tumor spheroid model for high-throughput cancer drug discovery","volume":"7","author":"LaBarbera","year":"2012","journal-title":"Expert Opin. Drug Discovery"},{"key":"bfabbd29bib36","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1007\/s10439-017-1797-5","type":"journal-article","article-title":"Compartmentalized culture of perivascular stroma and endothelial cells in a microfluidic model of the human endometrium","volume":"45","author":"Gnecco","year":"2017","journal-title":"Ann. Biomed. Eng."},{"key":"bfabbd29bib37","doi-asserted-by":"publisher","first-page":"e1926-e35","DOI":"10.1002\/term.2623","type":"journal-article","article-title":"Evaluation of an ovary-on-a-chip in large mammalian models: species specificity and influence of follicle isolation status","volume":"12","author":"Nagashima","year":"2018","journal-title":"J. Tissue Eng. Regener. Med."},{"key":"bfabbd29bib38","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1039\/c2ib00172a","type":"journal-article","article-title":"Co-cultured endometrial stromal cells and peritoneal mesothelial cells for an in vitro model of endometriosis","volume":"4","author":"Chen","year":"2012","journal-title":"Integr. Biol."},{"key":"bfabbd29bib39","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14584","type":"journal-article","article-title":"A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle","volume":"8","author":"Xiao","year":"2017","journal-title":"Nat. Commun."},{"key":"bfabbd29bib40","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/j.yexcr.2012.03.026","type":"journal-article","article-title":"Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system","volume":"318","author":"Karlsson","year":"2012","journal-title":"Exp. Cell Res."},{"key":"bfabbd29bib41","first-page":"910","type":"journal-article","article-title":"2D and 3D cell cultures - a comparison of different types of cancer cell cultures","volume":"14","author":"Kapalczynska","year":"2018","journal-title":"Arch. Med. Sci."},{"key":"bfabbd29bib42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059689","type":"journal-article","article-title":"Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines","volume":"8","author":"Luca","year":"2013","journal-title":"PLoS One"},{"key":"bfabbd29bib43","doi-asserted-by":"publisher","first-page":"112647","DOI":"10.18632\/oncotarget.22636","type":"journal-article","article-title":"3D-cultivation of NSCLC cell lines induce gene expression alterations of key cancer-associated pathways and mimic in-vivo conditions","volume":"8","author":"Gamerith","year":"2017","journal-title":"Oncotarget"},{"key":"bfabbd29bib44","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/s42003-020-0973-6","type":"journal-article","article-title":"Cells grown in three-dimensional spheroids mirror in vivo metabolic response of epithelial cells","volume":"3","author":"Lagies","year":"2020","journal-title":"Commun. Biol."},{"key":"bfabbd29bib45","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1242\/jcs.188102","type":"journal-article","article-title":"Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses","volume":"130","author":"Riedl","year":"2017","journal-title":"J. Cell. Sci."},{"key":"bfabbd29bib46","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.diff.2017.11.004","type":"journal-article","article-title":"Xenografted tissue models for the study of human endometrial biology","volume":"98","author":"Kuokkanen","year":"2017","journal-title":"Differentiation"},{"key":"bfabbd29bib47","doi-asserted-by":"publisher","first-page":"469","DOI":"10.2217\/nnm.10.12","type":"journal-article","article-title":"Engineering hydrogels as extracellular matrix mimics","volume":"5","author":"Geckil","year":"2010","journal-title":"Nanomedicine"},{"key":"bfabbd29bib48","author":"Willerth","year":"2008","type":"book"},{"key":"bfabbd29bib49","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/wrr.12192","type":"journal-article","article-title":"Hyaluronan enhances wound repair and increases collagen III in aged dermal wounds","volume":"22","author":"Damodarasamy","year":"2014","journal-title":"Wound Repair Regener."},{"key":"bfabbd29bib50","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/747584","type":"journal-article","article-title":"The role of the extracellular matrix components in cutaneous wound healing","volume":"2014","author":"Olczyk","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"bfabbd29bib51","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/346972","type":"journal-article","article-title":"Hyaluronan regulates cell behavior: a potential niche matrix for stem cells","volume":"2012","author":"Solis","year":"2012","journal-title":"Biochem. Res. Int."},{"key":"bfabbd29bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145068","type":"journal-article","article-title":"Collagen promotes higher adhesion, survival and proliferation of mesenchymal stem cells","volume":"10","author":"Somaiah","year":"2015","journal-title":"PLoS One"},{"key":"bfabbd29bib53","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3390\/cells7090114","type":"journal-article","article-title":"Impact of biomaterials on differentiation and reprogramming approaches for the generation of functional cardiomyocytes","volume":"7","author":"Paoletti","year":"2018","journal-title":"Cells"},{"key":"bfabbd29bib54","doi-asserted-by":"publisher","DOI":"10.1038\/srep32258","type":"journal-article","article-title":"Down-regulation of SerpinB2 is associated with gefitinib resistance in non-small cell lung cancer and enhances invadopodia-like structure protrusions","volume":"6","author":"Bae","year":"2016","journal-title":"Sci. Rep."},{"key":"bfabbd29bib55","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1126\/science.284.5411.143","type":"journal-article","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"bfabbd29bib56","doi-asserted-by":"publisher","first-page":"135","DOI":"10.15283\/ijsc.2014.7.2.135","type":"journal-article","article-title":"Characterization of mesenchymal stem cells derived from rat bone marrow and adipose tissue: a comparative study","volume":"7","author":"Lotfy","year":"2014","journal-title":"Int. J. Stem Cells"},{"key":"bfabbd29bib57","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.stem.2020.01.002","type":"journal-article","article-title":"Defining the adult neural stem cell niche proteome identifies key regulators of adult neurogenesis","volume":"26","author":"Kjell","year":"2020","journal-title":"Cell Stem Cell"},{"key":"bfabbd29bib58","first-page":"350","type":"journal-article","article-title":"Evidence for serpinB2-independent protection from TNF-alpha-induced apoptosis","volume":"312","author":"Fish","year":"2006","journal-title":"Exp. Cell Res."},{"key":"bfabbd29bib59","doi-asserted-by":"publisher","first-page":"E177","DOI":"10.1073\/pnas.1119296109","type":"journal-article","article-title":"TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2\/serpinB2 and transglutaminase 2","volume":"109","author":"Delhase","year":"2012","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"bfabbd29bib60","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/j.1478-3231.2010.02347.x","type":"journal-article","article-title":"Hypoxia-inducible factor-1alpha regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis","volume":"31","author":"Copple","year":"2011","journal-title":"Liver Int."},{"key":"bfabbd29bib61","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/B978-0-12-386471-0.00006-7","type":"journal-article","article-title":"Plasminogen activator inhibitor type 2: still an enigmatic serpin but a model for gene regulation","volume":"499","author":"Medcalf","year":"2011","journal-title":"Methods Enzymol."},{"key":"bfabbd29bib62","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00240-002-0270-5","type":"journal-article","article-title":"Plasminogen- and colony-stimulating factor-1-associated markers in bladder carcinoma: diagnostic value of urokinase plasminogen activator receptor and plasminogen activator inhibitor type-2 using immunocytochemical analysis","volume":"30","author":"Champelovier","year":"2002","journal-title":"Urol. Res."},{"key":"bfabbd29bib63","first-page":"4065","type":"journal-article","article-title":"Prognostic relevance of plasminogen activators and their inhibitors in colorectal cancer","volume":"54","author":"Ganesh","year":"1994","journal-title":"Cancer Res."},{"key":"bfabbd29bib64","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/ijc.1611","type":"journal-article","article-title":"High tumor tissue concentration of plasminogen activator inhibitor 2 (PAI-2) is an independent marker for shorter progression-free survival in patients with early stage endometrial cancer","volume":"97","author":"Nordengren","year":"2002","journal-title":"Int. J. Cancer"},{"key":"bfabbd29bib65","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1002\/1097-0142(19950401)75:7<1627::AID-CNCR2820750712>3.0.CO;2-V","type":"journal-article","article-title":"The significance of urokinase- type plasminogen activator, its inhibitors, and its receptor in ascites of patients with epithelial ovarian cancer","volume":"75","author":"Chambers","year":"1995","journal-title":"Cancer"}],"container-title":["Biofabrication"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/abbd29","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/abbd29\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/abbd29\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/abbd29","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/abbd29","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/abbd29\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/abbd29\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/abbd29\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/abbd29\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/abbd29\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/abbd29","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/abbd29\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T13:55:01Z","timestamp":1765029301000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/abbd29"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,16]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,10,16]]},"published-print":{"date-parts":[[2021,1,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1758-5090\/abbd29","relation":{},"ISSN":["1758-5082","1758-5090"],"issn-type":[{"value":"1758-5082","type":"print"},{"value":"1758-5090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,16]]},"assertion":[{"value":"Development of a novel dual reproductive organ on a chip: recapitulating bidirectional endocrine crosstalk between the uterine endometrium and the ovary","name":"article_title","label":"Article Title"},{"value":"Biofabrication","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2020 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-04-14","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-09-30","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-10-16","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}