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Davies Endowed Fellowship","award":["S1105-1002847-AWD"],"award-info":[{"award-number":["S1105-1002847-AWD"]}]},{"name":"Juvenile Diabetes Research Foundation","award":["3-PDF-2014-193-A-N"],"award-info":[{"award-number":["3-PDF-2014-193-A-N"]}]},{"name":"Diabetes Research Center","award":["P30 DK063491"],"award-info":[{"award-number":["P30 DK063491"]}],"id":[{"id":"https:\/\/ror.org\/05g02g987","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["UC4DK104202-01"],"award-info":[{"award-number":["UC4DK104202-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH","award":["2UC4DK098085"],"award-info":[{"award-number":["2UC4DK098085"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biofabrication"],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Insulin is an essential regulator of blood glucose homeostasis that is produced exclusively by\n                    <jats:italic>\u03b2<\/jats:italic>\n                    cells within the pancreatic islets of healthy individuals. In those affected by diabetes, immune inflammation, damage, and destruction of islet\n                    <jats:italic>\u03b2<\/jats:italic>\n                    cells leads to insulin deficiency and hyperglycemia. Current efforts to understand the mechanisms underlying\n                    <jats:italic>\u03b2<\/jats:italic>\n                    cell damage in diabetes rely on\n                    <jats:italic>in vitro<\/jats:italic>\n                    -cultured cadaveric islets. However, isolation of these islets involves removal of crucial matrix and vasculature that supports islets in the intact pancreas. Unsurprisingly, these islets demonstrate reduced functionality over time in standard culture conditions, thereby limiting their value for understanding native islet biology. Leveraging a novel, vascularized micro-organ (VMO) approach, we have recapitulated elements of the native pancreas by incorporating isolated human islets within a three-dimensional matrix nourished by living, perfusable blood vessels. Importantly, these islets show long-term viability and maintain robust glucose-stimulated insulin responses. Furthermore, vessel-mediated delivery of immune cells to these tissues provides a model to assess islet-immune cell interactions and subsequent islet killing\u2014key steps in type 1 diabetes pathogenesis. Together, these results establish the islet-VMO as a novel,\n                    <jats:italic>ex vivo<\/jats:italic>\n                    platform for studying human islet biology in both health and disease.\n                  <\/jats:p>","DOI":"10.1088\/1758-5090\/ad17d0","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T17:21:48Z","timestamp":1703179308000},"page":"025001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":39,"title":["A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction"],"prefix":"10.1088","volume":"16","author":[{"given":"R Hugh F","family":"Bender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3529-231X","authenticated-orcid":true,"given":"Benjamen T","family":"O\u2019Donnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupinder","family":"Shergill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany Q","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Tahmouresie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste N","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damie J","family":"Juat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela M S","family":"Hatch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venktesh S","family":"Shirure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Wortham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim-Vy","family":"Nguyen-Ngoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesl","family":"Jun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gaetani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L","family":"Christman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Teyton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Sander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C W","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"bfad17d0bib1","article-title":"National diabetes statistics report","author":"CDC"},{"key":"bfad17d0bib2","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/BF00452061","article-title":"The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom","volume":"29","author":"Foulis","year":"1986","journal-title":"Diabetologia"},{"key":"bfad17d0bib3","doi-asserted-by":"publisher","first-page":"2618","DOI":"10.2337\/db12-1387","article-title":"Next generation sequencing reveals the association of DRB302:02 with type 1 diabetes","volume":"62","author":"Erlich","year":"2013","journal-title":"Diabetes"},{"key":"bfad17d0bib4","first-page":"33","article-title":"Identification of an HLA-DQ \u03b2-chain related genomic sequence associated with insulin-dependent diabetes","volume":"44","author":"Michelsen","year":"1985","journal-title":"Biomed. 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