{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:10:12Z","timestamp":1788390612147,"version":"build-2803163510"},"reference-count":46,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"European Research Council","award":["BEACONSANDEGG"],"award-info":[{"award-number":["BEACONSANDEGG"]}]},{"DOI":"10.13039\/501100000844","name":"European Space Agency","doi-asserted-by":"crossref","award":["Nichoid in Space"],"award-info":[{"award-number":["Nichoid in Space"]}],"id":[{"id":"10.13039\/501100000844","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"crossref","award":["5M-2018-23680427"],"award-info":[{"award-number":["5M-2018-23680427"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biofabrication"],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The obtainment of innovative models recalling complex tumour architectures and activities\n                    <jats:italic>in vitro<\/jats:italic>\n                    is a challenging drive in the understanding of pathology molecular bases, yet it is a crucial path to the identification of targets for advanced oncotherapy. Cell environment recapitulation by 3D scaffolding and gravitational unloading of cell cultures represent powerful means in tumour biomimicry processes, but their simultaneous adoption has consistently been explored only in the latest decade. Here, an unprecedented bioengineering approach capitalizing on spaceflight biology practice is proposed for modelling of glioblastoma multiforme, a highly aggressive neoplasm that affects the central nervous system and has poorly effective pharmacological and radiological countermeasures. Tumour modelling was pursued by the original implementation of two-photon polymerization in fast prototyping of 3D scaffolds on flexible substrates for U87-MG glioma cell culture, and by the exposure of cell-laden scaffolds to simulated microgravity (s-\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g). Realistic spaceflight conditions were applied to collect preliminary information suitable for testing of U87-MG cell-laden scaffold in low Earth orbit. Responses of glioma cells anchored to 3D scaffolds were investigated by microscopy, quantitative reverse transcription-polymerase chain reaction and proteomic analyses, revealing synergic regulatory effects of cell scaffolding and s-\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g on markers of tumour cell growth, metabolism and invasiveness.\n                  <\/jats:p>","DOI":"10.1088\/1758-5090\/adbb21","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T17:52:11Z","timestamp":1740678731000},"page":"025024","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Two-photon polymerization of miniaturized 3D scaffolds optimized for studies on glioblastoma multiforme in spaceflight-like microgravity conditions"],"prefix":"10.1088","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2154-7991","authenticated-orcid":true,"given":"Giada Graziana","family":"Genchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2335-9046","authenticated-orcid":true,"given":"Claudio","family":"Conci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6237-0264","authenticated-orcid":false,"given":"\u00d6zlem","family":"\u015een","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9883-3905","authenticated-orcid":false,"given":"Alessandra","family":"Nardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5289-4219","authenticated-orcid":true,"given":"Martina","family":"Bartolucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3290-494X","authenticated-orcid":false,"given":"Attilio","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8728-5819","authenticated-orcid":true,"given":"Rebeca","family":"Martinez Vazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9534-2702","authenticated-orcid":true,"given":"Giulio","family":"Cerullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4457-9902","authenticated-orcid":false,"given":"Roberto","family":"Osellame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Petretto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2585-7206","authenticated-orcid":false,"given":"Manuela Teresa","family":"Raimondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1192-3647","authenticated-orcid":true,"given":"Gianni","family":"Ciofani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"bfadbb21bib1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fbioe.2016.00012","article-title":"In vitro tumor models\u202f: advantages, disadvantages, variables, and selecting the right platform","volume":"4","author":"Katt","year":"2016","journal-title":"Front. Bioeng. Biotechnol."},{"key":"bfadbb21bib2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3390\/bioengineering9040166","article-title":"In vitro cancer models\u202f: a closer look at limitations on translation","volume":"9","author":"Antunes","year":"2022","journal-title":"Bioengineering"},{"key":"bfadbb21bib3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12032-018-1083-x","article-title":"Cell biology of glioblastoma multiforme\u202f: from basic science to diagnosis and treatment","volume":"35","author":"Stoyanov","year":"2018","journal-title":"Med. Oncol."},{"key":"bfadbb21bib4","doi-asserted-by":"publisher","first-page":"469","DOI":"10.3390\/cancers11040469","article-title":"Pathological and molecular features of glioblastoma and its peritumoral tissue","volume":"11","author":"D\u2019Alessio","year":"2019","journal-title":"Cancers"},{"key":"bfadbb21bib5","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s10555-023-10100-7","article-title":"Considerations for modelling diffuse high grade gliomas and developing clinically relevant therapies","volume":"42","author":"Higginbottom","year":"2023","journal-title":"Cancer Metastasis Rev."},{"key":"bfadbb21bib6","doi-asserted-by":"publisher","first-page":"4304","DOI":"10.1016\/j.actbio.2014.05.032","article-title":"Acta biomaterialia the osteoprint\u202f: a bioinspired two-photon polymerized 3-D structure for the enhancement of bone-like cell differentiation","volume":"10","author":"Marino","year":"2014","journal-title":"Acta Biomater."},{"key":"bfadbb21bib7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep10531","article-title":"Microscaffolds for cell invasion studies","volume":"5","author":"Spagnolo","year":"2015","journal-title":"Sci. Rep."},{"key":"bfadbb21bib8","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.mattod.2017.06.004","article-title":"Two-photon polymerization for biological applications","volume":"20","author":"Nguyen","year":"2017","journal-title":"Mater. Today"},{"key":"bfadbb21bib9","doi-asserted-by":"publisher","DOI":"10.1002\/admt.202000540","article-title":"A 3D biohybrid real-scale model of the brain cancer microenvironment for advanced In vitro testing","volume":"5","author":"Tricinci","year":"2020","journal-title":"Adv. Mater. Technol."},{"key":"bfadbb21bib10","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202204485","article-title":"3D-engineered scaffolds to study microtubes and localization of epidermal growth factor receptor in patient\u2010derived glioma cells","volume":"18","author":"Barin","year":"2022","journal-title":"Small"},{"key":"bfadbb21bib11","doi-asserted-by":"publisher","DOI":"10.1063\/5.0155037","article-title":"Magnetic self-assembly of 3D multicellular microscaffolds\u202f: a biomimetic brain tumor-on-a-chip for drug delivery and selectivity testing","volume":"7","author":"Marino","year":"2023","journal-title":"APL Bioeng."},{"key":"bfadbb21bib12","doi-asserted-by":"publisher","first-page":"4579","DOI":"10.1016\/j.actbio.2012.08.022","article-title":"Three-dimensional structural niches engineered via two-photon laser polymerization promote stem cell homing","volume":"9","author":"Raimondi","year":"2013","journal-title":"Acta Biomater."},{"key":"bfadbb21bib13","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.945474","article-title":"Whole transcriptomic analysis of mesenchymal stem cells cultured in Nichoid micro-scaffolds","volume":"10","author":"Testa","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"bfadbb21bib14","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.neulet.2009.07.045","article-title":"Effects of simulated microgravity on proliferation and chemosensitivity in malignant glioma cells","volume":"463","author":"Takeda","year":"2009","journal-title":"Neurosci. Lett."},{"key":"bfadbb21bib15","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11626-009-9217-2","article-title":"Generation of a tumor spheroid in a microgravity environment as a 3D model of melanoma","volume":"45","author":"Marrero","year":"2009","journal-title":"In vitro Cell. Dev. Biol.: Anim."},{"key":"bfadbb21bib16","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1096\/fj.13-243287","article-title":"Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space","volume":"28","author":"Ma","year":"2014","journal-title":"FASEB J."},{"key":"bfadbb21bib17","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.bbrc.2014.12.120","article-title":"Modeled microgravity suppressed invasion and migration of human glioblastoma U87 cells through downregulating store-operated calcium entry","volume":"457","author":"Shi","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"bfadbb21bib18","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1007\/s11626-017-0178-6","article-title":"The influence of simulated microgravity on proliferation and apoptosis in U251 glioma cells","volume":"53","author":"Zhao","year":"2017","journal-title":"In vitro Cell. Dev. Biol.: Anim."},{"key":"bfadbb21bib19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50736-6","article-title":"Simulated microgravity with floating environment promotes migration of non-small cell lung cancers","volume":"9","author":"Ahn","year":"2019","journal-title":"Sci. Rep."},{"key":"bfadbb21bib20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-47116-5","article-title":"Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP","volume":"9","author":"Arun","year":"2019","journal-title":"Sci. Rep."},{"key":"bfadbb21bib21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21041263","article-title":"Simulated microgravity influences VEGF, MAPK, and PAM signaling in prostate cancer cells","volume":"21","author":"Hybel","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"bfadbb21bib22","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/pro6.1074","article-title":"Effects of rotary cell culture system-simulated microgravity on the ultrastructure and biological behavior of human MDA-MB-231 breast cancer cells","volume":"3","author":"Jiang","year":"2019","journal-title":"Precis. Radiat. Oncol."},{"key":"bfadbb21bib23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/971474","article-title":"Simulated microgravity: critical review on the use of random positioning machines for mammalian cell culture","volume":"2015","author":"Wuest","year":"2015","journal-title":"BioMed Res. Int."},{"key":"bfadbb21bib24","doi-asserted-by":"publisher","DOI":"10.1002\/adom.202101103","article-title":"A miniaturized imaging window to quantify intravital tissue regeneration within a 3D microscaffold in longitudinal studies","volume":"10","author":"Conci","year":"2022","journal-title":"Adv. Opt. Mater."},{"key":"bfadbb21bib25","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2021.100196","article-title":"Modulation of anti-angiogenic activity using ultrasound-activated nutlin-loaded piezoelectric nanovectors","volume":"13","author":"\u015een","year":"2022","journal-title":"Mater. Today Bio"},{"key":"bfadbb21bib26","doi-asserted-by":"publisher","first-page":"40200","DOI":"10.1021\/acsami.1c14176","article-title":"Cerium oxide nanoparticle administration to skeletal muscle cells under different gravity and radiation conditions","volume":"13","author":"Genchi","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bfadbb21bib27","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/nmeth.2834","article-title":"Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells","volume":"11","author":"Kulak","year":"2014","journal-title":"Nat. Methods"},{"key":"bfadbb21bib28","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1074\/mcp.M114.044305","article-title":"Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen-treated three-dimensional liver microtissues*","volume":"14","author":"Bruderer","year":"2015","journal-title":"Mol. Cell Proteomics"},{"key":"bfadbb21bib29","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"bfadbb21bib30","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/ng.3259","article-title":"Understanding multicellular function and disease with human tissue-specific networks","volume":"47","author":"Greene","year":"2015","journal-title":"Nat. Genet."},{"key":"bfadbb21bib31","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48080-w","article-title":"Multi-foci laser microfabrication of 3D polymeric scaffolds for stem cell expansion in regenerative medicine","volume":"9","author":"Zandrini","year":"2019","journal-title":"Sci. Rep."},{"key":"bfadbb21bib32","first-page":"945","article-title":"TGF-\u03b2 signaling and its targeting for glioma treatment","volume":"5","author":"Han","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"bfadbb21bib33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40659-018-0205-4","article-title":"Downregulation of TGF-\u03b21 suppressed proliferation and increased chemosensitivity of ovarian cancer cells by promoting BRCA1\/Smad3 signaling","volume":"51","author":"Wang","year":"2018","journal-title":"Biol. Res."},{"key":"bfadbb21bib34","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.3892\/or.2014.3434","article-title":"Downregulation of STAT3 and activation of MAPK are involved in the induction of apoptosis by HNK in glioblastoma cell line U87","volume":"32","author":"Zhang","year":"2014","journal-title":"Oncol. Rep."},{"key":"bfadbb21bib35","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1080\/15384101.2018.1557489","article-title":"Interaction with AEG-1 and MDM2 is associated with glioma development and progression and correlates with poor prognosis","volume":"18","author":"Ding","year":"2019","journal-title":"Cell Cycle"},{"key":"bfadbb21bib36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-88615-8","article-title":"MicroRNA\u2013138 suppresses glioblastoma proliferation through downregulation of CD44","volume":"11","author":"Yeh","year":"2021","journal-title":"Sci. Rep."},{"key":"bfadbb21bib37","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s10014-016-0260-x","article-title":"Immunohistochemistry on IDH 1\/2, ATRX, p53 and Ki-67 substitute molecular genetic testing and predict patient prognosis in grade III adult diffuse gliomas","volume":"33","author":"Takano","year":"2016","journal-title":"Brain Tumor Pathol."},{"key":"bfadbb21bib38","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s11060-019-03263-3","article-title":"Moderate hypothermia inhibits both proliferation and migration of human glioblastoma cells","volume":"144","author":"Fulbert","year":"2019","journal-title":"J. Neurooncol."},{"key":"bfadbb21bib39","doi-asserted-by":"publisher","first-page":"eabq4882","DOI":"10.1126\/sciadv.abq4882","article-title":"Cytostatic hypothermia and its impact on glioblastoma and survival","volume":"8","author":"Enam","year":"2022","journal-title":"Sci. Adv."},{"key":"bfadbb21bib40","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3390\/cells9020267","article-title":"Q-cell glioblastoma resource\u202f: proteomics analysis 3D culture","volume":"9","author":"D\u2019Souza","year":"2020","journal-title":"Cells"},{"key":"bfadbb21bib41","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202302280","article-title":"Unveiling the influence of tumor microenvironment and spatial heterogeneity on temozolomide resistance in glioblastoma using an advanced human In vitro model of the blood-brain barrier and glioblastoma","volume":"19","author":"Lam","year":"2023","journal-title":"Small"},{"key":"bfadbb21bib42","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s11060-019-03262-4","article-title":"Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics","volume":"144","author":"Chandran","year":"2019","journal-title":"J. Neurooncol."},{"key":"bfadbb21bib43","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202100106","article-title":"A 3D-bioprinted vascularized glioblastoma-on-a-chip for studying the impact of simulated microgravity as a novel pre-clinical approach in brain tumor therapy","volume":"4","author":"Silvani","year":"2021","journal-title":"Adv. Therap."},{"key":"bfadbb21bib44","doi-asserted-by":"publisher","first-page":"636","DOI":"10.3390\/biophysica3040043","article-title":"Microgravity as an anti-metastatic agent in an In vitro glioma model","volume":"3","author":"Sabbatini","year":"2023","journal-title":"Biophysica"},{"key":"bfadbb21bib45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fbioe.2018.00131","article-title":"Microenvironmental rigidity of 3D scaffolds and influence on glioblastoma cells\u202f: a biomaterial design perspective","volume":"6","author":"Palam\u00e0","year":"2018","journal-title":"Front. Bioeng. Biotechnol."},{"key":"bfadbb21bib46","doi-asserted-by":"publisher","DOI":"10.1063\/5.0153215","article-title":"3D photopolymerized microstructured scaffolds influence nuclear deformation, nucleo\/cytoskeletal protein organization, and gene regulation in mesenchymal stem cells","volume":"7","author":"Donnaloja","year":"2023","journal-title":"APL Bioeng."}],"container-title":["Biofabrication"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/adbb21","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/adbb21\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/adbb21","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/adbb21\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/adbb21\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/adbb21\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/adbb21\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/adbb21\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T05:37:16Z","timestamp":1741757836000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1758-5090\/adbb21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,12]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,3,12]]},"published-print":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1758-5090\/adbb21","relation":{},"ISSN":["1758-5082","1758-5090"],"issn-type":[{"value":"1758-5082","type":"print"},{"value":"1758-5090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,12]]},"assertion":[{"value":"Two-photon polymerization of miniaturized 3D scaffolds optimized for studies on glioblastoma multiforme in spaceflight-like microgravity conditions","name":"article_title","label":"Article Title"},{"value":"Biofabrication","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2025 The Author(s). Published by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2024-08-09","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-02-27","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-03-12","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}