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Vascularized spheroids, as highly active biological building blocks, can be applied in biomanufacturing to fabricate functional repair constructs. However, current methods of biofabricating endothelialized spheroids still face multiple technical limitations, including low throughput, poor uniformity, and insufficient controllability and observability. Furthermore, there is inadequate control over the spatial arrangement of the spheroids during vascularized construct biomanufacturing. We proposed a synergistic, shape-controlled spheroid\u2013hydrogel biomanufacturing method to address these issues, and developed a highly integrated, one-stop bioprinting platform for spheroids (OBPS) with real-time monitoring. We focused on key biomanufacturing stages, spheroid fabrication, bioprinting, and\n                    <jats:italic>in vivo<\/jats:italic>\n                    validation, to establish an integrated technical framework providing for \u2018fabrication\u2013culture\u2013assembly\u2013application.\u2019 Using the OBPS, we fabricated endothelialized spheroids by co-culturing human fibroblasts and human umbilical vein endothelial cells, printed fibrinogen-supplemented gelatin methacryloyl hydrogel, and bioprinted spheroids and hydrogels\n                    <jats:italic>in situ<\/jats:italic>\n                    onto full-thickness skin defects in nude mice. Animal experiments show that shape-controlled endothelialized spheroids significantly accelerated wound closure, suppressed inflammation, promoted neovascularization and collagen remodeling, and exhibited excellent tissue integration and repair potential. The OBPS system provides a novel and effective treatment for wound healing.\n                  <\/jats:p>","DOI":"10.1088\/1758-5090\/ae9598","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T22:53:27Z","timestamp":1785970407000},"page":"045004","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic, shape-controlled endothelialized spheroid\u2013hydrogel for wound healing"],"prefix":"10.1088","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1101-2051","authenticated-orcid":true,"given":"Chunxiang","family":"Lu","sequence":"first","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University"},{"name":"School of Intelligent Manufacturing and Control Engineering, Shanghai Polytechnic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangying","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2357-6312","authenticated-orcid":true,"given":"Huazhen","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine, Shanghai University"},{"name":"Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine"},{"name":"The First Affiliated Hospital of Naval Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6771-1443","authenticated-orcid":true,"given":"Wenbin","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"He","sequence":"additional","affiliation":[{"name":"School of Medicine, Shanghai University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9215-3941","authenticated-orcid":true,"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Shanghai University"},{"name":"MedEng-X Institutes, Shanghai University"},{"name":"National Center for Translational Medicine (Shanghai) SHU Branch"},{"name":"School of Medicine, Shanghai University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"bfae9598bib1","article-title":"Wound physiology","author":"Grubbs","year":"2018","type":"other"},{"key":"bfae9598bib2","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/s13287-018-1044-5","type":"journal-article","article-title":"A review: therapeutic potential of adipose-derived stem cells in cutaneous wound healing and regeneration","volume":"9","author":"Li","year":"2018","journal-title":"Stem Cell Res. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2026-01-06","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-08-05","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-09-28","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}