{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:16:14Z","timestamp":1783937774523,"version":"3.55.0"},"reference-count":48,"publisher":"IOP Publishing","issue":"7","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":12,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"}],"funder":[{"name":"Fundamental Research Grant Scheme","award":["FRGS\/1\/2022\/SKK05\/UM\/02\/1"],"award-info":[{"award-number":["FRGS\/1\/2022\/SKK05\/UM\/02\/1"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Med. Eng. Phys."],"published-print":{"date-parts":[[2026,7,1]]},"DOI":"10.1088\/1873-4030\/ae8543","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:47:47Z","timestamp":1783032467000},"page":"075003","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Patient-specific left ventricular hypertrophy under severe hypertension: mechanistic insights from hill-type computational simulations"],"prefix":"10.1088","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4809-2665","authenticated-orcid":true,"given":"Nurul Jannah","family":"Zamberi","sequence":"first","affiliation":[{"name":"Universiti Malaya"},{"name":"University of New South Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2775-4529","authenticated-orcid":false,"given":"Chin Neng","family":"Leong","sequence":"additional","affiliation":[{"name":"University of New South Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-8135","authenticated-orcid":false,"given":"Azam Ahmad","family":"Bakir","sequence":"additional","affiliation":[{"name":"Universiti Teknologi Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6625-1430","authenticated-orcid":true,"given":"Bee Ting","family":"Chan","sequence":"additional","affiliation":[{"name":"University of Nottingham Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2487-3933","authenticated-orcid":true,"given":"Yih Miin","family":"Liew","sequence":"additional","affiliation":[{"name":"Universiti Malaya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-2044","authenticated-orcid":true,"given":"Andri","family":"Andriyana","sequence":"additional","affiliation":[{"name":"Universiti Malaya"},{"name":"Universitas Airlangga"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2432-3993","authenticated-orcid":false,"given":"Farina","family":"Muhamad","sequence":"additional","affiliation":[{"name":"Universiti Malaya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7399-2712","authenticated-orcid":false,"given":"Socrates","family":"Dokos","sequence":"additional","affiliation":[{"name":"University of New South Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2037-4213","authenticated-orcid":true,"given":"Einly","family":"Lim","sequence":"additional","affiliation":[{"name":"Universiti Malaya"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"mepae8543bib1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48670-8","type":"journal-article","article-title":"Model of anisotropic reverse cardiac growth in mechanical dyssynchrony","volume":"9","author":"Arumugam","year":"2019","journal-title":"Sci. Rep."},{"key":"mepae8543bib2","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1007\/s10237-019-01268-5","type":"journal-article","article-title":"The impact of wall thickness and curvature on wall stress in patient-specific electromechanical models of the left atrium","volume":"19","author":"Augustin","year":"2020","journal-title":"Biomech. Model. Mechanobiol."},{"key":"mepae8543bib3","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.3389\/fphys.2018.01259","type":"journal-article","article-title":"A multiphysics biventricular cardiac model: simulations with a left-ventricular assist device","volume":"9","author":"Bakir","year":"2018","journal-title":"Front. Physiol."},{"key":"mepae8543bib4","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s00466-022-02206-6","type":"journal-article","article-title":"A coupling strategy for a first 3D-1D model of the cardiovascular system to study the effects of pulse wave propagation on cardiac function","volume":"70","author":"Caforio","year":"2022","journal-title":"Comput. Mech."},{"key":"mepae8543bib5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocs.2024.102496","type":"journal-article","article-title":"A phenomenological discrete model for cardiac tissue mechanics","volume":"85","author":"Campos","year":"2025","journal-title":"J. Comput. Sci."},{"key":"mepae8543bib6","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1161\/CIRCULATIONAHA.114.012960","type":"journal-article","article-title":"Histopathological Basis of myocardial late gadolinium enhancement in patients with systemic hypertension","volume":"130","author":"Chaowu","year":"2014","journal-title":"Circulation"},{"key":"mepae8543bib7","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1016\/j.jbiomech.2016.03.009","type":"journal-article","article-title":"Study of cardiovascular function using a coupled left ventricle and systemic circulation model","volume":"49","author":"Chen","year":"2016","journal-title":"J. Biomech."},{"key":"mepae8543bib8","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/j.jbiomech.2010.02.022","type":"journal-article","article-title":"Influence of left-ventricular shape on passive filling properties and end-diastolic fiber stress and strain","volume":"43","author":"Choi","year":"2010","journal-title":"J. Biomech."},{"key":"mepae8543bib9","type":"software","article-title":"COMSOL Multiphysics\u00ae","author":"COMSOL","year":"2022","unstructured":"COMSOL 2022 COMSOL Multiphysics\u00ae Version 6.1, COMSOL AB, Stockholm, Sweden"},{"key":"mepae8543bib10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2025.108800","type":"journal-article","article-title":"Modelling of cardiac biventricular electromechanics with coronary blood flow to investigate the influence of coronary arterial motion on coronary haemodynamic","volume":"267","author":"Delestri","year":"2025","journal-title":"Comput. Methods Programs Biomed."},{"key":"mepae8543bib11","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s10237-020-01385-6","type":"journal-article","article-title":"A multiscale model of cardiac concentric hypertrophy incorporating both mechanical and hormonal drivers of growth","volume":"20","author":"Estrada","year":"2021","journal-title":"Biomech. Model. Mechanobiol."},{"key":"mepae8543bib12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cma.2023.115983","type":"journal-article","article-title":"A comprehensive and biophysically detailed computational model of the whole human heart electromechanics","volume":"410","author":"Fedele","year":"2023","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"mepae8543bib13","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12968-014-0087-8","type":"journal-article","article-title":"In vivo cardiovascular magnetic resonance diffusion tensor imaging shows evidence of abnormal myocardial laminar orientations and mobility in hypertrophic cardiomyopathy","volume":"16","author":"Ferreira","year":"2014","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"mepae8543bib14","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2017.0203","type":"journal-article","article-title":"Changes and classification in myocardial contractile function in the left ventricle following acute myocardial infarction","volume":"14","author":"Gao","year":"2017","journal-title":"J. Royal. Soc. Interface"},{"key":"mepae8543bib15","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jtbi.2010.04.023","type":"journal-article","article-title":"A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis","volume":"265","author":"G\u00f6ktepe","year":"2010","journal-title":"J. Theor. Biol."},{"key":"mepae8543bib16","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s12265-018-9792-2","type":"journal-article","article-title":"Patient-specific cardiovascular computational modeling: diversity of personalization and challenges","volume":"11","author":"Gray","year":"2018","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"mepae8543bib17","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2022.105417","type":"journal-article","article-title":"A new active contraction model for the myocardium using a modified hill model","volume":"145","author":"Guan","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"mepae8543bib18","author":"Guyton","year":"2011","edition":"12th","type":"book"},{"key":"mepae8543bib19","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/anae.13348","type":"journal-article","article-title":"The measurement of adult blood pressure and management of hypertension before elective surgery","volume":"71","author":"Hartle","year":"2016","journal-title":"Anaesthesia"},{"key":"mepae8543bib20","first-page":"136","type":"conference-proceedings","article-title":"The heat of shortening and the dynamic constants of muscle","volume":"126","author":"Hill","year":"1938"},{"key":"mepae8543bib21","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3390\/math10050823","type":"journal-article","article-title":"An integrated workflow for building digital twins of cardiac electromechanics-a multi-fidelity approach for personalising active mechanics","volume":"10","author":"Jung","year":"2022","journal-title":"Mathematics"},{"key":"mepae8543bib22","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.mechrescom.2011.11.004","type":"journal-article","article-title":"A single strain-based growth law predicts concentric and eccentric cardiac growth during pressure and volume overload","volume":"42","author":"Kerckhoffs","year":"2012","journal-title":"Mech. Res. Commun."},{"key":"mepae8543bib23","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.mechrescom.2012.03.005","type":"journal-article","article-title":"Growth and remodeling of the left ventricle: a case study of myocardial infarction and surgical ventricular restoration","volume":"42","author":"Klepach","year":"2012","journal-title":"Mech. Res. Commun."},{"key":"mepae8543bib24","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s10237-008-0136-z","type":"journal-article","article-title":"Computational modeling of volumetric soft tissue growth: application to the cardiac left ventricle","volume":"8","author":"Kroon","year":"2009","journal-title":"Biomech. Model. Mechanobiol."},{"key":"mepae8543bib25","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.yjmcc.2017.03.008","type":"journal-article","article-title":"A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes","volume":"106","author":"Land","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"mepae8543bib26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s10237-014-0598-0","type":"journal-article","article-title":"A computational model that predicts reverse growth in response to mechanical unloading","volume":"14","author":"Lee","year":"2015","journal-title":"Biomech. Model. Mechanobiol."},{"key":"mepae8543bib27","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s10237-015-0723-8","type":"journal-article","article-title":"An integrated electromechanical-growth heart model for simulating cardiac therapies","volume":"15","author":"Lee","year":"2016","journal-title":"Biomech. Model. Mechanobiol."},{"key":"mepae8543bib28","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1007\/s00466-023-02346-3","type":"journal-article","article-title":"A multiphysical computational model of myocardial growth adopted to human pathological ventricular remodelling","volume":"72","author":"Lee","year":"2023","journal-title":"Comput. Mech."},{"key":"mepae8543bib29","doi-asserted-by":"publisher","first-page":"H2466","DOI":"10.1152\/ajpheart.1997.272.5.H2466","type":"journal-article","article-title":"Laminar structure of the heart: a mathematical model","volume":"272","author":"Legrice","year":"1997","journal-title":"Am. J. Physiol."},{"key":"mepae8543bib30","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2794","type":"journal-article","article-title":"The role of infarct transmural extent in infarct extension: a computational study","volume":"33","author":"Leong","year":"2017","journal-title":"Int. J. Numer. Methods Biomed. Eng."},{"key":"mepae8543bib31","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.1088\/0031-9155\/60\/7\/2715","type":"journal-article","article-title":"Motion corrected LV quantification based on 3D modelling for improved functional assessment in cardiac MRI","volume":"60","author":"Liew","year":"2015","journal-title":"Phys. Med. Biol."},{"key":"mepae8543bib32","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41569-018-0104-y","type":"journal-article","article-title":"Computational models in cardiology","volume":"16","author":"Niederer","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"mepae8543bib33","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.pbiomolbio.2007.08.001","type":"journal-article","article-title":"An improved numerical method for strong coupling of excitation and contraction models in the heart","volume":"96","author":"Niederer","year":"2008","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"mepae8543bib34","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1002\/cnm.1405","type":"journal-article","article-title":"Fluid\u2013solid coupling for the investigation of diastolic and systolic human left ventricular function","volume":"27","author":"Nordsletten","year":"2011","journal-title":"Int. J. Numer. Methods Biomed. Eng."},{"key":"mepae8543bib35","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1093\/qjmam\/hbq014","type":"journal-article","article-title":"Cardiac electromechanics: the effect of contraction model on the mathematical problem and accuracy of the numerical scheme","volume":"63","author":"Pathmanathan","year":"2010","journal-title":"Q. J. Mech. Appl. Math."},{"key":"mepae8543bib36","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1475-925X-12-54","type":"journal-article","article-title":"Mathematical model of the anatomy and fibre orientation field of the left ventricle of the heart","volume":"12","author":"Pravdin","year":"2013","journal-title":"Biomed. Eng. Online"},{"key":"mepae8543bib37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008294","type":"journal-article","article-title":"Biophysically detailed mathematical models of multiscale cardiac active mechanics","volume":"16","author":"Regazzoni","year":"2020","journal-title":"PLoS Comput. Biol."},{"key":"mepae8543bib38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cma.2020.113506","type":"journal-article","article-title":"An oscillation-free fully staggered algorithm for velocity-dependent active models of cardiac mechanics","volume":"373","author":"Regazzoni","year":"2021","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"mepae8543bib39","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1529\/biophysj.107.119487","type":"journal-article","article-title":"Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations","volume":"95","author":"Rice","year":"2008","journal-title":"Biophys. J."},{"key":"mepae8543bib40","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1097\/RLI.0b013e3181238330","type":"journal-article","article-title":"Reconstruction and visualization of fiber and laminar structure in the normal human heart from ex vivo diffusion tensor magnetic resonance imaging (DTMRI) data","volume":"42","author":"Rohmer","year":"2007","journal-title":"Invest. Radiol."},{"key":"mepae8543bib41","author":"Starling","year":"1918","type":"book"},{"key":"mepae8543bib42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1011257","type":"journal-article","article-title":"Cell to whole organ global sensitivity analysis on a four-chamber heart electromechanics model using Gaussian processes emulators","volume":"19","author":"Strocchi","year":"2023","journal-title":"PLoS Comput. Biol."},{"key":"mepae8543bib43","article-title":"Hypertensive heart disease StatPearls","author":"Tackling","year":"2024","type":"book"},{"key":"mepae8543bib44","doi-asserted-by":"publisher","first-page":"659","DOI":"10.3389\/fphys.2016.00659","type":"journal-article","article-title":"Modulating beta-cardiac myosin function at the molecular and tissue levels","volume":"7","author":"Tang","year":"2016","journal-title":"Front. Physiol."},{"key":"mepae8543bib45","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1109\/MPUL.2011.942054","type":"journal-article","article-title":"Laplace\u2019s law: what it is about, where it comes from, and how it is often applied in physiology [Retrospectroscope]","volume":"2","author":"Valentinuzzi","year":"2011","journal-title":"Pulse, IEEE"},{"key":"mepae8543bib46","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","type":"journal-article","article-title":"ESC\/ESH Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the european society of cardiology (ESC) and the european society of hypertension (ESH)","volume":"39","author":"Williams","year":"2018","journal-title":"Eur. Heart J."},{"key":"mepae8543bib47","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.pcad.2019.11.009","type":"journal-article","article-title":"Left ventricular hypertrophy and hypertension","volume":"63","author":"Yildiz","year":"2020","journal-title":"Prog. Cardiovasc. Dis."},{"key":"mepae8543bib48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10255842.2025.2514130","type":"journal-article","article-title":"The influence of Hill\u2019s force-velocity relation on left ventricular mechanics in simulated hypertensive conditions with variable afterload","author":"Zamberi","year":"2025","journal-title":"Comput. Methods Biomech. Biomed. Eng."}],"container-title":["Medical Engineering & Physics"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/ae8543","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/ae8543\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/ae8543","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/ae8543\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/ae8543\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/ae8543\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/ae8543\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/ae8543\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:32:34Z","timestamp":1783935154000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/ae8543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":48,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7,13]]},"published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1873-4030\/ae8543","relation":{},"ISSN":["1350-4533","1873-4030"],"issn-type":[{"value":"1350-4533","type":"print"},{"value":"1873-4030","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"Patient-specific left ventricular hypertrophy under severe hypertension: mechanistic insights from hill-type computational simulations","name":"article_title","label":"Article Title"},{"value":"Medical Engineering & Physics","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2026 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd.","name":"copyright_information","label":"Copyright Information"},{"value":"2026-03-23","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-07-02","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-07-13","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}