{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:50:52Z","timestamp":1792057852156,"version":"4.4.0"},"reference-count":40,"publisher":"IOP Publishing","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":14,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Med. Eng. Phys."],"published-print":{"date-parts":[[2026,10,1]]},"DOI":"10.1088\/1873-4030\/aeb093","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:47:21Z","timestamp":1791298041000},"page":"105007","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A two-timescale reduced-order model coupling acute arterial compliance with stress- and shear-regulated growth and remodeling"],"prefix":"10.1088","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7425-4546","authenticated-orcid":true,"given":"Ahmet","family":"\u00c7al\u0131k","sequence":"first","affiliation":[{"name":"Burdur Mehmet Akif Ersoy University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"mepaeb093bib1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.04645","type":"journal-article","article-title":"Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point","volume":"4","author":"Baeyens","year":"2015","journal-title":"eLife"},{"key":"mepaeb093bib2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10659-021-09833-9","type":"journal-article","article-title":"Global sensitivity analysis of a homogenized constrained mixture model of arterial growth and remodeling","volume":"145","author":"Brandstaeter","year":"2021","journal-title":"J. Elast."},{"key":"mepaeb093bib3","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1007\/s10237-016-0770-9","type":"journal-article","article-title":"A homogenized constrained mixture (and mechanical analog) model for growth and remodeling of soft tissue","volume":"15","author":"Cyron","year":"2016","journal-title":"Biomech. Model. Mechanobiol."},{"key":"mepaeb093bib4","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1161\/ATVBAHA.125.322557","type":"journal-article","article-title":"Fluid shear stress-regulated vascular remodeling: past, present and future","volume":"45","author":"Deng","year":"2025","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"mepaeb093bib5","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1093\/cvr\/cvm055","type":"journal-article","article-title":"Alteration in flow (shear stress)-induced remodelling in rat resistance arteries with aging: improvement by a treatment with hydralazine","volume":"77","author":"Dumont","year":"2008","journal-title":"Cardiovascular Res."},{"key":"mepaeb093bib6","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1097\/HJH.0b013e32832e8dc8","type":"journal-article","article-title":"Importance of pulsatility in hypertensive carotid artery growth and remodeling","volume":"27","author":"Eberth","year":"2009","journal-title":"J. Hypertension"},{"key":"mepaeb093bib7","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1098\/rsif.2005.0073","type":"journal-article","article-title":"Hyperelastic modelling of arterial layers with distributed collagen fibre orientations","volume":"3","author":"Gasser","year":"2006","journal-title":"J. Royal. Soc. Interface"},{"key":"mepaeb093bib8","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/s41598-023-50816-8","type":"journal-article","article-title":"Renal denervation restores biomechanics of carotid arteries in a rat model of hypertension","volume":"14","author":"Gkousioudi","year":"2024","journal-title":"Sci. Rep."},{"key":"mepaeb093bib9","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1159\/000080699","type":"journal-article","article-title":"A mixture model of arterial growth and remodeling in hypertension: altered muscle tone and tissue turnover","volume":"41","author":"Gleason","year":"2004","journal-title":"J. Vasc. Res."},{"key":"mepaeb093bib10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/nrm2596","type":"journal-article","article-title":"Mechanotransduction in vascular physiology and atherogenesis","volume":"10","author":"Hahn","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"mepaeb093bib11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1023\/A:1010835316564","type":"journal-article","article-title":"A new constitutive framework for arterial wall mechanics and a comparative study of material models","volume":"61","author":"Holzapfel","year":"2000","journal-title":"J. Elast."},{"key":"mepaeb093bib12","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1098\/rspa.2010.0058","type":"journal-article","article-title":"Constitutive modelling of arteries","volume":"466","author":"Holzapfel","year":"2010","journal-title":"Proc. R. Soc. A"},{"key":"mepaeb093bib13","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1161\/HYPERTENSIONAHA.107.103440","type":"journal-article","article-title":"Mechanisms of arterial remodeling in hypertension: coupled roles of wall shear and intramural stress","volume":"52","author":"Humphrey","year":"2008","journal-title":"Hypertension"},{"key":"mepaeb093bib14","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10659-020-09809-1","type":"journal-article","article-title":"Constrained mixture models of soft tissue growth and remodeling\u2013twenty years after","volume":"145","author":"Humphrey","year":"2021","journal-title":"J. Elast."},{"key":"mepaeb093bib15","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1142\/S0218202502001714","type":"journal-article","article-title":"A constrained mixture model for growth and remodeling of soft tissues","volume":"12","author":"Humphrey","year":"2002","journal-title":"Math. Models Methods Appl. Sci."},{"key":"mepaeb093bib16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-bioeng-092419-060810","type":"journal-article","article-title":"Vascular mechanobiology: homeostasis, adaptation and disease","volume":"23","author":"Humphrey","year":"2021","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"mepaeb093bib17","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s10237-026-02088-0","type":"journal-article","article-title":"Mechanics and mechanobiology of arterial development","volume":"25","author":"Humphrey","year":"2026","journal-title":"Biomech. Model. Mechanobiol."},{"key":"mepaeb093bib18","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1007\/s10237-022-01593-2","type":"journal-article","article-title":"Intracellular signaling control of mechanical homeostasis in the aorta","volume":"21","author":"Irons","year":"2022","journal-title":"Biomech. Model. Mechanobiol."},{"key":"mepaeb093bib19","doi-asserted-by":"publisher","first-page":"H14","DOI":"10.1152\/ajpheart.1980.239.1.H14","type":"journal-article","article-title":"Adaptive regulation of wall shear stress to flow change in the canine carotid artery","volume":"239","author":"Kamiya","year":"1980","journal-title":"Am. J. Physiol."},{"key":"mepaeb093bib20","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s10237-017-0946-y","type":"journal-article","article-title":"Mechanobiological model of arterial growth and remodeling","volume":"17","author":"Keshavarzian","year":"2018","journal-title":"Biomech. Model. Mechanobiol."},{"key":"mepaeb093bib21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmps.2026.106525","type":"journal-article","article-title":"Nonlinear mechanics of arterial growth","volume":"210","author":"Kumar","year":"2026","journal-title":"J. Mech. Phys. Solids"},{"key":"mepaeb093bib22","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1126\/science.3941904","type":"journal-article","article-title":"Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent","volume":"231","author":"Langille","year":"1986","journal-title":"Science"},{"key":"mepaeb093bib23","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1002\/zamm.201700302","type":"journal-article","article-title":"A mechanobiologically equilibrated constrained mixture model for growth and remodeling of soft tissues","volume":"98","author":"Latorre","year":"2018","journal-title":"ZAMM-J. Appl. Math. Mech."},{"key":"mepaeb093bib24","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1098\/rsif.2011.0177","type":"journal-article","article-title":"Role of shear stress and stretch in vascular mechanobiology","volume":"8","author":"Lu","year":"2011","journal-title":"J. Royal. Soc. Interface"},{"key":"mepaeb093bib25","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1115\/1.2895731","type":"journal-article","article-title":"Mechanical and dimensional adaptation of rat aorta to hypertension","volume":"116","author":"Matsumoto","year":"1994","journal-title":"J. Biomech. Eng."},{"key":"mepaeb093bib26","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/j.1365-2613.2006.00506.x","type":"journal-article","article-title":"Circumferential wall tension due to hypertension plays a pivotal role in aorta remodelling","volume":"87","author":"Prado","year":"2006","journal-title":"Int. J. Exp. Pathol."},{"key":"mepaeb093bib27","doi-asserted-by":"publisher","first-page":"H349","DOI":"10.1152\/ajpheart.1998.275.2.H349","type":"journal-article","article-title":"Structural adaptation and stability of microvascular networks","volume":"275","author":"Pries","year":"1998","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"mepaeb093bib28","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1115\/1.2834313","type":"journal-article","article-title":"A model for geometric and mechanical adaptation of arteries to sustained hypertension","volume":"120","author":"Rachev","year":"1998","journal-title":"J. Biomech. Eng."},{"key":"mepaeb093bib29","doi-asserted-by":"publisher","first-page":"10347","DOI":"10.1073\/pnas.1409233111","type":"journal-article","article-title":"Piezo1, a mechanically activated ion channel, is required for vascular development in mice","volume":"111","author":"Ranade","year":"2014","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"mepaeb093bib30","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1093\/bioinformatics\/btp358","type":"journal-article","article-title":"Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood","volume":"25","author":"Raue","year":"2009","journal-title":"Bioinformatics"},{"key":"mepaeb093bib31","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s11517-008-0330-2","type":"journal-article","article-title":"Wall shear stress as measured in vivo: Consequences for the design of the arterial system","volume":"46","author":"Reneman","year":"2008","journal-title":"Med. Biol. Eng. Comput."},{"key":"mepaeb093bib32","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1161\/HYPERTENSIONAHA.111.187021","type":"journal-article","article-title":"Vascular remodeling in hypertension: mechanisms and treatment","volume":"59","author":"Schiffrin","year":"2012","journal-title":"Hypertension"},{"key":"mepaeb093bib33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1137\/S1064827594276424","type":"journal-article","article-title":"The MATLAB ODE suite","volume":"18","author":"Shampine","year":"1997","journal-title":"SIAM J. Sci. Comput."},{"key":"mepaeb093bib34","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nature03952","type":"journal-article","article-title":"A mechanosensory complex that mediates the endothelial cell response to fluid shear stress","volume":"437","author":"Tzima","year":"2005","journal-title":"Nature"},{"key":"mepaeb093bib35","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1098\/rsif.2008.0254","type":"journal-article","article-title":"Complementary vasoactivity and matrix remodelling in arterial adaptations to altered flow and pressure","volume":"6","author":"Valent\u00edn","year":"2009","journal-title":"J. Royal. Soc. Interface"},{"key":"mepaeb093bib36","doi-asserted-by":"publisher","DOI":"10.1115\/1.3192144","type":"journal-article","article-title":"Parameter sensitivity study of a constrained mixture model of arterial growth and remodeling","volume":"131","author":"Valent\u00edn","year":"2009","journal-title":"J. Biomech. Eng."},{"key":"mepaeb093bib37","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1007\/s10237-023-01697-3","type":"journal-article","article-title":"A multiscale computational model of arterial growth and remodeling including Notch signaling","volume":"22","author":"van Asten","year":"2023","journal-title":"Biomech. Model. Mechanobiol."},{"key":"mepaeb093bib38","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/cells6030019","type":"journal-article","article-title":"Vascular mechanobiology: Towards control of in situ regeneration","volume":"6","author":"Van Haaften","year":"2017","journal-title":"Cells"},{"key":"mepaeb093bib39","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/0021-9290(94)00012-S","type":"journal-article","article-title":"Identification of elastic properties of homogeneous, orthotropic vascular segments in distension","volume":"28","author":"Vorp","year":"1995","journal-title":"J. Biomech."},{"key":"mepaeb093bib40","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.70190","type":"journal-article","article-title":"Arterial growth and remodeling in layered and toroidal geometries using constrained mixture theory","volume":"42","author":"Weissmann","year":"2026","journal-title":"Int. J. Numer. Methods Biomed. Eng."}],"container-title":["Medical Engineering & Physics"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/aeb093","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/aeb093\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/aeb093","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/aeb093\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/aeb093\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/aeb093\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/aeb093\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/aeb093\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:43:30Z","timestamp":1792057410000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1873-4030\/aeb093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":40,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10,15]]},"published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1873-4030\/aeb093","relation":{},"ISSN":["1350-4533","1873-4030"],"issn-type":[{"value":"1350-4533","type":"print"},{"value":"1873-4030","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"A two-timescale reduced-order model coupling acute arterial compliance with stress- and shear-regulated growth and remodeling","name":"article_title","label":"Article Title"},{"value":"Medical Engineering & Physics","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2026 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd.","name":"copyright_information","label":"Copyright Information"},{"value":"2026-09-04","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-09-30","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-10-15","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}