{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:32:10Z","timestamp":1773725530255,"version":"3.50.1"},"reference-count":31,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Phys. Eng. Express"],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report detection of cervical pre-cancer through their low coherence images by applying two dimensional multifractal detrended fluctuation analysis. Low coherent backscattered images of pre-cancerous cervical tissue sections were captured using a common path interferometric setup. The captured images contain both depth and lateral information of the spatial variation in refractive index (RI) occurring with progression of cervical pre-cancer. A two-dimensional multifractal detrended fluctuation analysis (2D MFDFA) was applied on these low coherent images to study the variations occurring in their fractal nature. Long-range correlations were observed in the RI fluctuations and the strength of multifractality was found to be stronger for higher grades of cervical pre-cancer. A combination of derived multifractal parameters, namely, the generalized Hurst exponent and width of singularity spectrum showed clear differences among the different grades of pre-cancers. Normal, CIN-I and CIN-II were clearly discriminated by application of support vector machine (SVM) using radial Bessel function (RBF) kernel. The specificities and sensitivities between normal and CIN-I, CIN-I and CIN-II and normal and CIN-II were found to be 94%, 88% and 93%, 96% and 98%, 100% respectively.<\/jats:p>","DOI":"10.1088\/2057-1976\/ab6e17","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T17:30:18Z","timestamp":1579627818000},"page":"025011","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Two dimensional multifractal detrended fluctuation analysis of low coherence images for diagnosis of cervical pre-cancer"],"prefix":"10.1088","volume":"6","author":[{"given":"Gyana Ranjan","family":"Sahoo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajib","family":"Dey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandan","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmalya","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3351-0141","authenticated-orcid":false,"given":"Asima","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"bpexab6e17bib1","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1364\/OL.28.001230","type":"journal-article","volume":"28","author":"Wax","year":"2003","journal-title":"Opt. 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