{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:48:59Z","timestamp":1787500139246,"version":"build-2736575974"},"reference-count":118,"publisher":"IOP Publishing","issue":"3","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Phys. Eng. Express"],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer is a broad-spectrum disease which is spread globally, having high mortality rates. This results from genetic, epigenetic and molecular abnormalities caused by various mutations. The main reason behind this critical problem lies in its diagnostics, the late detection of the disease is the root cause of all this. This can be managed well by the timely diagnosis of cancer by means of the tumor biomarkers present in the body fluids such as serum, blood, and urine. These tumor biomarkers are present in normal conditions as well, but their concentrations are altered in the presence of a malignant tumor. Prolonged studies have reported that immunosensors can be used to detect the minimal amount of biomarkers present in the sample and also provides point-of-care detection. The recent investigations demonstrated the use of polymers along with immunosensors for enhancing their selectivity and sensitivity towards the biomarkers and making them even more efficient. This review focuses on the variety of tumor biomarkers, different types of immunosensors and polymeric immunosensors using different polymers like polypyrrole, polyaniline, PHEMA, etc.<\/jats:p>","DOI":"10.1088\/2057-1976\/ab8a75","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T18:17:36Z","timestamp":1587147456000},"page":"032001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Polymeric immunosensors for tumor detection"],"prefix":"10.1088","volume":"6","author":[{"given":"Saloni","family":"Tandon","sequence":"first","affiliation":[{"name":"University of Rajasthan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchi Mercy","family":"George","sequence":"additional","affiliation":[{"name":"Nano Surface Texturing Lab, Department of Metallurgical and Materials Engineering, Defence Institute of Advanced Technology (DU), Girinagar, Pune-411025,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Iconiq Innovation, Commercial House, Millbank Business Park, Lucan, Co. Dublin,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4257-8807","authenticated-orcid":false,"given":"Balasubramanian","family":"Kandasubramanian","sequence":"additional","affiliation":[{"name":"Nano Surface Texturing Lab, Department of Metallurgical and Materials Engineering, Defence Institute of Advanced Technology (DU), Girinagar, Pune-411025,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"bpexab8a75bib1","first-page":"106","type":"journal-article","article-title":"Latest global cancer data: Cancer burden rises to 18.1 million new cases and 9.6 million cancer deaths in 2018","volume":"50","author":"World Health Organisation","year":"2018","journal-title":"International Agency of Research on Cancer"},{"key":"bpexab8a75bib2","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2019.120251","type":"journal-article","article-title":"Electrochemical biosensors for the detection of lung cancer biomarkers: a review","volume":"206","author":"Khanmohammadi","year":"2020","journal-title":"Talanta"},{"key":"bpexab8a75bib3","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jcrpr.2017.07.001","type":"journal-article","article-title":"Review of cancer from perspective of molecular","volume":"4","author":"Hassanpour","year":"2017","journal-title":"J. Cancer Res. Pract."},{"key":"bpexab8a75bib4","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1039\/C8BM01642A","type":"journal-article","article-title":"A polydopamine-based platform for anti-cancer drug delivery","volume":"7","author":"Ambekar","year":"2019","journal-title":"Biomater. Sci."},{"key":"bpexab8a75bib5","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/315550a0","type":"journal-article","article-title":"Fused transcript of abl and bcr genes in chronic myelogenous leukaemia","volume":"315","author":"Shtivelman","year":"1985","journal-title":"Nature"},{"key":"bpexab8a75bib6","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature17038","type":"journal-article","article-title":"Metastatic colonization by circulating tumour cells","volume":"529","author":"Massagu\u00e9","year":"2016","journal-title":"Nature"},{"key":"bpexab8a75bib7","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ctrv.2008.10.004","type":"journal-article","article-title":"The footprints of cancer development: cancer biomarkers","volume":"35","author":"Ullah","year":"2009","journal-title":"Cancer Treat. Rev."},{"key":"bpexab8a75bib8","doi-asserted-by":"publisher","first-page":"186","DOI":"10.13057\/nusbiosci\/n060212","type":"journal-article","article-title":"Advancements and application of immunosensors in the analysis of food contaminants","volume":"6","author":"Azam","year":"2014","journal-title":"Nusant. Biosci."},{"key":"bpexab8a75bib9","doi-asserted-by":"publisher","first-page":"69733","DOI":"10.1039\/C6RA09554B","type":"journal-article","article-title":"The dielectric properties and charge transport mechanism of \u03c0-conjugated segments decorated with intrinsic conducting polymer","volume":"6","author":"Tahalyani","year":"2016","journal-title":"RSC Adv."},{"key":"bpexab8a75bib10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.122430","type":"journal-article","article-title":"Naturally biomimicked smart shape memory hydrogels for biomedical functions","volume":"379","author":"Korde","year":"2020","journal-title":"Chem. Eng. J."},{"key":"bpexab8a75bib11","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1021\/acsomega.9b03816","type":"journal-article","article-title":"Advancements in hydrogel-functionalized immunosensing platforms","volume":"5","author":"George","year":"2020","journal-title":"ACS Omega"},{"key":"bpexab8a75bib12","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1067\/mcp.2001.113989","type":"journal-article","article-title":"Biomarkers and surrogate endpoints: preferred definitions and conceptual framework","volume":"69","author":"Atkinson","year":"2001","journal-title":"Clin. Pharmacol. Ther."},{"key":"bpexab8a75bib13","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.molonc.2012.01.010","type":"journal-article","article-title":"Cancer biomarkers","volume":"6","author":"Henry","year":"2012","journal-title":"Mol. Oncol."},{"key":"bpexab8a75bib14","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.3390\/cancers3022554","type":"journal-article","article-title":"State of the art in tumor antigen and biomarker discovery","volume":"3","author":"Even-Desrumeaux","year":"2011","journal-title":"Cancers (Basel)."},{"key":"bpexab8a75bib15","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2019.120153","type":"journal-article","article-title":"Nanostructures for nonlabeled and labeled electrochemical immunosensors: Simultaneous electrochemical detection of cancer markers: a review","volume":"205","author":"Filik","year":"2019","journal-title":"Talanta"},{"key":"bpexab8a75bib16","doi-asserted-by":"publisher","DOI":"10.5772\/60524","type":"book","article-title":"Immunosensors","author":"Cristea","year":"2015"},{"key":"bpexab8a75bib17","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/bs.acc.2015.10.004","type":"book","article-title":"Immunosensors in Clinical Laboratory Diagnostics","author":"Justino","year":"2016"},{"key":"bpexab8a75bib18","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.talanta.2014.08.063","type":"journal-article","article-title":"Applications of electrochemical immunosensors for early clinical diagnostics","volume":"132","author":"Burcu Bahadir","year":"2015","journal-title":"Talanta"},{"key":"bpexab8a75bib19","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jelechem.2009.01.016","type":"journal-article","article-title":"Enhancement of carcinoembryonic antibody immobilization on gold electrode modified by gold nanoparticles and SiO2\/Thionine nanocomposite","volume":"628","author":"Zhuo","year":"2009","journal-title":"J. Electroanal. Chem."},{"key":"bpexab8a75bib20","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1016\/j.trac.2010.07.008","type":"journal-article","article-title":"Review of analytical figures of merit of sensors and biosensors in clinical applications","volume":"29","author":"Justino","year":"2010","journal-title":"TrAC\u2014Trends Anal. Chem."},{"key":"bpexab8a75bib21","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.trac.2012.12.012","type":"journal-article","article-title":"Advances in point-of-care technologies with biosensors based on carbon nanotubes","volume":"45","author":"Justino","year":"2013","journal-title":"TrAC\u2014Trends Anal. Chem."},{"key":"bpexab8a75bib22","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s10854-012-0765-y","type":"journal-article","article-title":"Effect of la on piezoelectric properties of Pb(Ni1\/3Sb 2\/3)O3-Pb(ZrTi)O3 ferroelectric ceramics","volume":"24","author":"Lonkar","year":"2013","journal-title":"J. Mater. Sci. Mater. Electron."},{"key":"bpexab8a75bib23","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0065-2423(08)60337-6","type":"journal-article","article-title":"Immunosensors for clinical analysis","volume":"31","author":"Aizawa","year":"1994","journal-title":"Advances in Clinical Chemistry"},{"key":"bpexab8a75bib24","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/S0956-5663(99)00032-9","type":"journal-article","article-title":"The use of regenerable, affinity ligand-based surfaces for immunosensor applications Biosens","volume":"14","author":"Quinn","year":"1999","journal-title":"Bioelectron."},{"key":"bpexab8a75bib25","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/S0040-6090(95)08426-6","type":"journal-article","article-title":"Langmuir films of Fc binding receptors engineered from protein A and protein G as a sublayer for immunoglobulin orientation","volume":"284\u2013285","author":"Dubrovsky","year":"1996","journal-title":"Thin Solid Films"},{"key":"bpexab8a75bib26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S1050-3862(99)00034-0","type":"journal-article","article-title":"Avidin and streptavidin in clinical diagnostics","volume":"16","author":"Schetters","year":"1999","journal-title":"Biomolecular Engineering"},{"key":"bpexab8a75bib27","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0022-1759(98)00167-7","type":"journal-article","article-title":"Surface plasmon resonance: a study of the effect of biotinylation on the selection of antibodies for use in immunoassays","volume":"221","author":"Pearson","year":"1998","journal-title":"J. Immunol. Methods"},{"key":"bpexab8a75bib28","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1039\/an996210029r","type":"journal-article","article-title":"Oriented immobilization of antibodies and its applications in immunoassays and immunosensors","volume":"121","author":"Lu","year":"1996","journal-title":"Analyst"},{"key":"bpexab8a75bib29","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0021-9673(01)93763-X","type":"journal-article","article-title":"Site-directed immobilization of proteins","volume":"510","author":"Domen","year":"1990","journal-title":"J. Chromatogr. A"},{"key":"bpexab8a75bib30","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0956-5663(97)00107-3","type":"journal-article","article-title":"Immobilisation of multilayer bioreceptor assemblies on solid substrates Biosens","volume":"13","author":"Brynda","year":"1998","journal-title":"Bioelectron."},{"key":"bpexab8a75bib31","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1021\/ac950756u","type":"journal-article","article-title":"A novel method of immobilizing antibodies on a quartz crystal microbalance using plasma-polymerized films for immunosensors","volume":"68","author":"Nakanishi","year":"1996","journal-title":"Anal. Chem."},{"key":"bpexab8a75bib32","doi-asserted-by":"publisher","first-page":"11161","DOI":"10.1021\/ac403331m","type":"journal-article","article-title":"Nanomaterials in analytical chemistry","volume":"85","author":"Ligler","year":"2013","journal-title":"Anal. Chem."},{"key":"bpexab8a75bib33","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1021\/ac011127p","type":"journal-article","article-title":"Development of an aggregation-based immunoassay for anti-protein A using gold nanoparticles","volume":"74","author":"Kim Thanh","year":"2002","journal-title":"Anal. Chem."},{"key":"bpexab8a75bib34","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/S0956-5663(03)00252-5","type":"journal-article","article-title":"Application of impedance spectroscopy for monitoring colloid Au-enhanced antibody immobilization and antibody-antigen reactions Biosens","volume":"19","author":"Wang","year":"2004","journal-title":"Bioelectron."},{"key":"bpexab8a75bib35","doi-asserted-by":"publisher","first-page":"7240","DOI":"10.1021\/la030428m","type":"journal-article","article-title":"Ultrasensitive potentiometric immunosensor based on SA and OCA techniques for immobilization of HBsAb with colloidal Au and polyvinyl butyral as matrixes","volume":"20","author":"Yuan","year":"2004","journal-title":"Langmuir"},{"key":"bpexab8a75bib36","doi-asserted-by":"publisher","first-page":"18501","DOI":"10.1039\/C4RA15269G","type":"journal-article","article-title":"Encapsulation of gold nanoparticles with PHB based on coffee ring effect","volume":"5","author":"Yadav","year":"2015","journal-title":"RSC Adv."},{"key":"bpexab8a75bib37","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.snb.2005.02.011","type":"journal-article","article-title":"A reusable capacitive immunosensor with a novel immobilization procedure based on 1,6-hexanedithiol and nano-Au self-assembled layers","volume":"110","author":"Li","year":"2005","journal-title":"Sensors Actuators, B Chem."},{"key":"bpexab8a75bib38","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0003-2670(03)00089-8","type":"journal-article","article-title":"Piezoelectric immunosensor based on magnetic nanoparticles with simple immobilization procedures","volume":"481","author":"Li","year":"2003","journal-title":"Anal. Chim. Acta"},{"key":"bpexab8a75bib39","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.snb.2005.04.002","type":"journal-article","article-title":"Core\u2013shell magnetic nanoparticles applied for immobilization of antibody on carbon paste electrode and amperometric immunosensing","volume":"113","author":"Liu","year":"2006","journal-title":"Sensors Actuators, B Chem."},{"key":"bpexab8a75bib40","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0956-5663(01)00115-4","type":"journal-article","article-title":"Electrochemical biosensors: recommended definitions and classification Biosens","volume":"16","author":"Th\u00e9venot","year":"2001","journal-title":"Bioelectron."},{"key":"bpexab8a75bib41","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1021\/ac00045a031","type":"journal-article","article-title":"Biosensor based on conducting polymers","volume":"64","author":"Hoa","year":"1992","journal-title":"Anal. Chem."},{"key":"bpexab8a75bib42","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/S0956-5663(03)00020-4","type":"journal-article","article-title":"A conductometric biosensor for biosecurity Biosens","volume":"18","author":"Muhammad-Tahir","year":"2003","journal-title":"Bioelectron."},{"key":"bpexab8a75bib43","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/j.elecom.2008.04.009","type":"journal-article","article-title":"A conductometric immunosensor based on functionalized magnetite nanoparticles for E. coli detection","volume":"10","author":"Hnaiein","year":"2008","journal-title":"Electrochem. Commun."},{"key":"bpexab8a75bib44","doi-asserted-by":"publisher","first-page":"4407","DOI":"10.3390\/s90604407","type":"journal-article","article-title":"Antibody-based sensors: principles, problems and potential for detection of pathogens and associated toxins","volume":"9","author":"Byrne","year":"2009","journal-title":"Sensors (Switzerland)"},{"key":"bpexab8a75bib45","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0022-1759(96)00076-2","type":"journal-article","article-title":"Enzyme-linked immunomagnetic electrochemical detection of Salmonella typhimurium","volume":"195","author":"Gehring","year":"1996","journal-title":"J. Immunol. Methods"},{"key":"bpexab8a75bib46","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1002\/(SICI)1521-4109(20000301)12:5<317::AID-ELAN317=3.0.CO;2-A","type":"journal-article","article-title":"Application of electrochemical biosensors for detection of food pathogenic bacteria","volume":"12","author":"Ivnitski","year":"2000","journal-title":"Electroanalysis"},{"key":"bpexab8a75bib47","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.bios.2016.12.070","type":"journal-article","article-title":"A novel sandwich-type electrochemical immunosensor for PSA detection based on PtCu bimetallic hybrid (2D\/2D) rGO\/g-C3N4 Biosens","volume":"91","author":"Feng","year":"2017","journal-title":"Bioelectron."},{"key":"bpexab8a75bib48","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.electacta.2015.02.050","type":"journal-article","article-title":"A sandwich-type electrochemical immunosensor based on multiple signal amplification for \u03b1-fetoprotein labeled by platinum hybrid multiwalled carbon nanotubes adhered copper oxide","volume":"160","author":"Jiang","year":"2015","journal-title":"Electrochim. Acta"},{"key":"bpexab8a75bib49","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.sna.2008.12.021","type":"journal-article","article-title":"Flexible and disposable immunosensors based on layer-by-layer self-assembled carbon nanotubes and biomolecules","volume":"150","author":"Lu","year":"2009","journal-title":"Sensors Actuators, A Phys."},{"key":"bpexab8a75bib50","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1093\/nar\/28.16.3011","type":"journal-article","article-title":"SURVEY AND SUMMARY: From DNA biosensors to gene chips","volume":"28","author":"Wang","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"bpexab8a75bib51","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1093\/clinchem\/44.9.2015","type":"journal-article","article-title":"Ligand assays: from electrophoresis to miniaturized microarrays","volume":"44","author":"Ekins","year":"1998","journal-title":"Clin. Chem."},{"key":"bpexab8a75bib52","doi-asserted-by":"publisher","first-page":"9972","DOI":"10.1073\/pnas.97.18.9972","type":"journal-article","article-title":"Unbinding forces of single antibody-antigen complexes correlate with their thermal dissociation rates","volume":"97","author":"Schwesinger","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"bpexab8a75bib53","first-page":"872","type":"conference-proceedings","article-title":"An optical immunosensor using carbon nanotube (CNT)coated with photovoltaic polymer","author":"Shim","year":"2009"},{"key":"bpexab8a75bib54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0009-8981(01)00629-5","type":"journal-article","article-title":"Immunosensors\u2014Principles and applications to clinical chemistry","volume":"314","author":"Luppa","year":"2001","journal-title":"Clin. Chim. Acta"},{"key":"bpexab8a75bib55","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1021\/ac034748m","type":"journal-article","article-title":"Immunosensor for detection of yersinia e nterocolitica based on imaging ellipsometry","volume":"76","author":"Bae","year":"2004","journal-title":"Anal. Chem."},{"key":"bpexab8a75bib56","doi-asserted-by":"publisher","first-page":"i","DOI":"10.1016\/0956-5663(95)96965-2","type":"journal-article","article-title":"Biosensing with surface plasmon resonance\u2014how it all started Biosens","volume":"10","author":"Liedberg","year":"1995","journal-title":"Bioelectron."},{"key":"bpexab8a75bib57","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.trac.2008.09.018","type":"journal-article","article-title":"Sensors and biosensors in support of EU Directives","volume":"28","author":"Farr\u00e9","year":"2009","journal-title":"TrAC\u2014Trends Anal. Chem."},{"key":"bpexab8a75bib58","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.bios.2008.04.018","type":"journal-article","article-title":"A new MSPQC for rapid growth and detection of Mycobacterium tuberculosis Biosens","volume":"24","author":"Ren","year":"2008","journal-title":"Bioelectron."},{"key":"bpexab8a75bib59","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2116\/analsci.16.107","type":"journal-article","article-title":"Design and application of piezoelectric quartz crystal-based immunoassay","volume":"16","author":"Su","year":"2000","journal-title":"Anal. Sci."},{"key":"bpexab8a75bib60","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/BF01337937","type":"journal-article","article-title":"Verwendung von Schwingquarzen zur W\u00e4gung d\u00fcnner Schichten und zur Mikrow\u00e4gung","volume":"155","author":"Sauerbrey","year":"1959","journal-title":"Zeitschrift f\u00fcr Phys."},{"key":"bpexab8a75bib61","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1039\/B511662G","type":"journal-article","article-title":"Piezoelectric immunosensor for bisphenol A based on signal enhancing step with 2-methacrolyloxyethyl phosphorylcholine polymeric nanoparticle","volume":"131","author":"Park","year":"2006","journal-title":"Analyst"},{"key":"bpexab8a75bib62","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3390\/s18020451","type":"journal-article","article-title":"Polymeric flexible immunosensor based on piezoresistive micro-cantilever with PEDOT\/PSS conductive layer","volume":"18","author":"Zhao","year":"2018","journal-title":"Sensors"},{"key":"bpexab8a75bib63","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1002\/ange.19860980537","type":"book","article-title":"Analytical solution calorimetry","volume":"98","author":"Ackermann","year":"1986"},{"key":"bpexab8a75bib64","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0956-5663(01)00124-5","type":"journal-article","article-title":"Principles and applications of thermal biosensors","volume":"16","author":"Ramanathan","year":"2001","journal-title":"Biosensors and Bioelectronics"},{"key":"bpexab8a75bib65","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.bios.2016.10.058","type":"journal-article","article-title":"Self-assembled polymeric nanoparticles film stabilizing gold nanoparticles as a versatile platform for ultrasensitive detection of carcino-embryonic antigen Biosens","volume":"92","author":"Xu","year":"2017","journal-title":"Bioelectron."},{"key":"bpexab8a75bib66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/9781119592990.ch1","type":"book","article-title":"Nanomaterials and the Environment","author":"Rastogi","year":"2020"},{"key":"bpexab8a75bib67","doi-asserted-by":"publisher","first-page":"4667","DOI":"10.1016\/S0013-4686(99)00265-0","type":"journal-article","article-title":"Monitoring antibody-antigen reactions at conducting polymer-based immunosensors using impedance spectroscopy","volume":"44","author":"Sargent","year":"1999","journal-title":"Electrochim. Acta"},{"key":"bpexab8a75bib68","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S0003-2670(99)00531-0","type":"journal-article","article-title":"New label-free DNA recognition based on doping nucleic-acid probes within conducting polymer films","volume":"402","author":"Wang","year":"1999","journal-title":"Anal. Chim. Acta"},{"key":"bpexab8a75bib69","doi-asserted-by":"publisher","first-page":"3581","DOI":"10.1021\/ac981201c","type":"journal-article","article-title":"Polypyrrole-entrapped quinohemoprotein alcohol dehydrogenase. Evidence for direct electron transfer via conducting-polymer chains","volume":"71","author":"Ramanavicius","year":"1999","journal-title":"Anal. Chem."},{"key":"bpexab8a75bib70","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0956-5663(91)87039-E","type":"journal-article","article-title":"Electropolymerized films to prevent interferences and electrode fouling in biosensors Biosens","volume":"6","author":"Geise","year":"1991","journal-title":"Bioelectron."},{"key":"bpexab8a75bib71","doi-asserted-by":"publisher","first-page":"8522","DOI":"10.1016\/j.ceramint.2019.12.257","type":"journal-article","article-title":"Advancements in MXene-Polymer composites for various biomedical applications","volume":"46","author":"George","year":"2020","journal-title":"Ceram. Int."},{"key":"bpexab8a75bib72","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1039\/AN9931800329","type":"journal-article","article-title":"Molecular recognition using conducting polymers: basis of an electrochemical sensing technology: plenary lecture","volume":"4","author":"Teasdale","year":"1993","journal-title":"Analyst"},{"key":"bpexab8a75bib73","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0003-2670(96)00361-3","type":"journal-article","article-title":"Selectivity and sensitivity of ultrathin purine-templated overoxidized polypyrrole film electrodes","volume":"336","author":"Spurlock","year":"1996","journal-title":"Anal. Chim. Acta"},{"key":"bpexab8a75bib74","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/361645a0","type":"journal-article","article-title":"Drug assay using antibody mimics made by molecular imprinting","volume":"361","author":"Vlatakis","year":"1993","journal-title":"Nature"},{"key":"bpexab8a75bib75","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/0924-4247(93)80134-3","type":"journal-article","article-title":"Some studies of molecularly-imprinted polymer membranes in combination with field-effect devices","volume":"37\u201338","author":"Hedborg","year":"1993","journal-title":"Sensors Actuators A. Phys."},{"key":"bpexab8a75bib76","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/B978-0-12-799947-0.00025-0","type":"book","article-title":"Synthesis, characterization, and development of PZT-based composition for power harvesting and sensors application","author":"Lonkar","year":"2015"},{"key":"bpexab8a75bib77","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.bios.2016.06.028","type":"journal-article","article-title":"Gold nanoparticles and polyethylene glycols functionalized conducting polyaniline nanowires for ultrasensitive and low fouling immunosensing of alpha-fetoprotein Biosens","volume":"86","author":"Hui","year":"2016","journal-title":"Bioelectron."},{"key":"bpexab8a75bib78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-43740-3","type":"journal-article","article-title":"Graphene quantum dots decorated gold-polyaniline nanowire for impedimetric detection of carcinoembryonic antigen","volume":"9","author":"Ganganboina","year":"2019","journal-title":"Scientific Reports"},{"key":"bpexab8a75bib79","doi-asserted-by":"publisher","first-page":"17178","DOI":"10.1039\/C9RA02565K","type":"journal-article","article-title":"A label-free immunosensor based on PHEMA\/graphene oxide nanocomposite for simultaneous electrochemical determination of alpha","volume":"9","author":"Liang","year":"2019","journal-title":"fetoprotein RSC Adv."},{"key":"bpexab8a75bib80","doi-asserted-by":"publisher","first-page":"14763","DOI":"10.1039\/c2jm31663c","type":"journal-article","article-title":"Mediator free highly sensitive polyaniline\u2013gold hybrid nanocomposite based immunosensor for prostate-specific antigen (PSA) detection","volume":"22","author":"Dey","year":"2012","journal-title":"J. Mater. Chem."},{"key":"bpexab8a75bib81","doi-asserted-by":"publisher","first-page":"753","DOI":"10.3390\/cancers11060753","type":"journal-article","article-title":"A multifunctional graphene oxide platform for targeting cancer","volume":"11","author":"Bug\u00e1rov\u00e1","year":"2019","journal-title":"Cancers (Basel)."},{"key":"bpexab8a75bib82","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1021\/ac802319f","type":"journal-article","article-title":"Single conducting polymer nanowire chemiresistive label-free immunosensor for cancer biomarker","volume":"81","author":"Bangar","year":"2009","journal-title":"Anal. Chem."},{"key":"bpexab8a75bib83","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.bios.2007.03.023","type":"journal-article","article-title":"A disposable two-throughput electrochemical immunosensor chip for simultaneous multianalyte determination of tumor markers Biosens","volume":"23","author":"Wu","year":"2007","journal-title":"Bioelectron."},{"key":"bpexab8a75bib84","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.bios.2012.02.064","type":"journal-article","article-title":"Electrochemical immunoassay for carcinoembryonic antigen based on signal amplification strategy of nanotubular mesoporous PdCu alloy Biosens","volume":"36","author":"Cai","year":"2012","journal-title":"Bioelectron."},{"key":"bpexab8a75bib85","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.talanta.2013.07.069","type":"journal-article","article-title":"Electrochemical immunoassay for carcinoembryonic antigen using gold nanoparticle-graphene composite modified glassy carbon electrode","volume":"116","author":"Zhu","year":"2013","journal-title":"Talanta"},{"key":"bpexab8a75bib86","doi-asserted-by":"publisher","first-page":"2786","DOI":"10.1016\/j.bios.2010.10.042","type":"journal-article","article-title":"A novel electrochemical immunoassay based on diazotization-coupled functionalized bioconjugates as trace labels for ultrasensitive detection of carcinoembryonic antigen Biosens","volume":"26","author":"Jiang","year":"2011","journal-title":"Bioelectron."},{"key":"bpexab8a75bib87","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jelechem.2008.10.031","type":"journal-article","article-title":"Electrochemical amperometric immunoassay for carcinoembryonic antigen based on bi-layer nano-Au and nickel hexacyanoferrates nanoparticles modified glassy carbon electrode","volume":"626","author":"Yuan","year":"2009","journal-title":"J. Electroanal. Chem."},{"key":"bpexab8a75bib88","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.bej.2011.04.004","type":"journal-article","article-title":"Electrochemical immunosensor for detecting carcinoembryonic antigen using hollow Pt nanospheres-labeled multiple enzyme-linked antibodies as labels for signal amplification","volume":"56","author":"Yang","year":"2011","journal-title":"Biochem. Eng. J."},{"key":"bpexab8a75bib89","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.ejcts.2007.05.014","type":"journal-article","article-title":"Prognostic value of carcinoembryonic antigen and CYFRA21-1 in patients with pathological stage I non-small cell lung cancer","volume":"32","author":"Matsuoka","year":"2007","journal-title":"Eur. J. Cardio-thoracic Surg."},{"key":"bpexab8a75bib90","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.colsurfb.2010.05.012","type":"journal-article","article-title":"A sensitive amperometric immunosensor for alpha-fetoprotein based on carbon nanotube\/DNA\/Thi\/nano-Au modified glassy carbon electrode","volume":"79","author":"Ran","year":"2010","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"bpexab8a75bib91","doi-asserted-by":"publisher","first-page":"9001","DOI":"10.1021\/acs.chemrev.6b00220","type":"journal-article","article-title":"Electrochemical methods for the analysis of clinically relevant biomolecules","volume":"116","author":"Labib","year":"2016","journal-title":"Chem. Rev."},{"key":"bpexab8a75bib92","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.aca.2008.03.054","type":"journal-article","article-title":"A reagentless amperometric immunosensor for \u03b1-1-fetoprotein based on gold nanowires and ZnO nanorods modified electrode","volume":"615","author":"Lu","year":"2008","journal-title":"Anal. Chim. Acta"},{"key":"bpexab8a75bib93","doi-asserted-by":"publisher","first-page":"3763","DOI":"10.1016\/j.electacta.2005.10.039","type":"journal-article","article-title":"A new potentiometric immunosensor for determination of \u03b1-fetoprotein based on improved gelatin-silver complex film","volume":"51","author":"Qiang","year":"2006","journal-title":"Electrochim. Acta"},{"key":"bpexab8a75bib94","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.electacta.2013.10.018","type":"journal-article","article-title":"Electrochemical immunosensor for alpha-fetoprotein determination based on ZnSe quantum dots\/Azure I\/gold nanoparticles\/poly (3,4-ethylenedioxythiophene) modified Pt electrode","volume":"114","author":"Liu","year":"2013","journal-title":"Electrochim. Acta"},{"key":"bpexab8a75bib95","first-page":"1","type":"journal-article","article-title":"Biosensors: the new wave in cancer diagnosis","volume":"4","author":"Bohunicky","year":"2011","journal-title":"Nanotechnol. Sci. Appl."},{"key":"bpexab8a75bib96","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.talanta.2008.04.026","type":"journal-article","article-title":"A novel electrochemical immunosensor based on colabeled silica nanoparticles for determination of total prostate specific antigen in human serum","volume":"76","author":"Qu","year":"2008","journal-title":"Talanta"},{"key":"bpexab8a75bib97","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.bios.2007.11.003","type":"journal-article","article-title":"Integrated microfluidic systems with an immunosensor modified with carbon nanotubes for detection of prostate specific antigen (PSA) in human serum samples Biosens","volume":"23","author":"Panini","year":"2008","journal-title":"Bioelectron."},{"key":"bpexab8a75bib98","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.aca.2006.01.094","type":"journal-article","article-title":"Electrochemical immuno-bioanalysis for carcinoma antigen 125 based on thionine and gold nanoparticles-modified carbon paste interface","volume":"564","author":"Tang","year":"2006","journal-title":"Anal. Chim. Acta"},{"key":"bpexab8a75bib99","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.cca.2013.07.017","type":"journal-article","article-title":"Berindan-Neagoe I and S\u01cendulescu R 2013 Electrochemical immunosensors in breast and ovarian cancer","volume":"425","author":"Diaconu","journal-title":"Clin. Chim. Acta"},{"key":"bpexab8a75bib100","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.aca.2008.11.068","type":"journal-article","article-title":"Ferrocenyl-doped silica nanoparticles as an immobilized affinity support for electrochemical immunoassay of cancer antigen 15-3","volume":"633","author":"Hong","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"bpexab8a75bib101","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.bios.2014.01.020","type":"journal-article","article-title":"Nonenzymatic immunosensor for detection of carbohydrate antigen 15-3 based on hierarchical nanoporous PtFe alloy Biosens","volume":"56","author":"Li","year":"2014","journal-title":"Bioelectron."},{"key":"bpexab8a75bib102","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.snb.2013.02.063","type":"journal-article","article-title":"An electrochemical immunosensor based on gold nanoparticle tags for picomolar detection of c-Myc oncoprotein","volume":"181","author":"He","year":"2013","journal-title":"Sensors Actuators, B Chem."},{"key":"bpexab8a75bib103","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.snb.2012.08.072","type":"journal-article","article-title":"Application of magnetic core\u2013shell microspheres on reagentless immunosensor based on direct electrochemistry of glucose oxidase for detection of carbohydrate antigen 19-9","volume":"176","author":"Hu","year":"2013","journal-title":"Sensors Actuators, B Chem."},{"key":"bpexab8a75bib104","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jim.2003.08.014","type":"journal-article","article-title":"Immunological assay for carbohydrate antigen 19-9 using an electrochemical immunosensor and antigen immobilization in titania sol-gel matrix","volume":"283","author":"Du","year":"2003","journal-title":"J. Immunol. Methods"},{"key":"bpexab8a75bib105","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.bios.2013.05.063","type":"journal-article","article-title":"Electrochemical impedance immunosensor based on gold nanoparticles-protein G for the detection of cancer marker epidermal growth factor receptor in human plasma and brain tissue Biosens","volume":"50","author":"Elshafey","year":"2013","journal-title":"Bioelectron."},{"key":"bpexab8a75bib106","doi-asserted-by":"publisher","first-page":"5011","DOI":"10.1210\/en.2007-0286","type":"journal-article","article-title":"Human chorionic gonadotropin produced by the invasive trophoblast but not the villous trophoblast promotes cell invasion and is down-regulated by peroxisome proliferator-activated receptor-\u03b3","volume":"148","author":"Handschuh","year":"2007","journal-title":"Endocrinology"},{"key":"bpexab8a75bib107","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.bios.2011.11.054","type":"journal-article","article-title":"Ultrasensitive electrochemical immunosensor based on Au nanoparticles dotted carbon nanotube-graphene composite and functionalized mesoporous materials Biosens","volume":"33","author":"Lu","year":"2012","journal-title":"Bioelectron."},{"key":"bpexab8a75bib108","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.bios.2012.01.004","type":"journal-article","article-title":"Ultrasensitive electrochemical immunosensor for HE4 based on rolling circle amplification Biosens","volume":"33","author":"Lu","year":"2012","journal-title":"Bioelectron."},{"key":"bpexab8a75bib109","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.bios.2013.02.014","type":"journal-article","article-title":"Ultrasensitive electrochemical immunoassay for squamous cell carcinoma antigen using dumbbell-like Pt-Fe3O4 nanoparticles as signal amplification Biosens","volume":"46","author":"Wu","year":"2013","journal-title":"Bioelectron."},{"key":"bpexab8a75bib110","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.bios.2012.07.049","type":"journal-article","article-title":"Label-free impedimetric immunosensor for ultrasensitive detection of cancer marker Murine double minute 2 in brain tissue Biosens","volume":"39","author":"Elshafey","year":"2013","journal-title":"Bioelectron."},{"key":"bpexab8a75bib111","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.bios.2011.10.055","type":"journal-article","article-title":"Novel electrochemical catalysis as signal amplified strategy for label-free detection of neuron-specific enolase Biosens","volume":"31","author":"Han","year":"2012","journal-title":"Bioelectron."},{"key":"bpexab8a75bib112","doi-asserted-by":"publisher","first-page":"4032","DOI":"10.1016\/j.bios.2011.03.025","type":"journal-article","article-title":"A new impedimetric biosensor utilizing VEGF receptor-1 (Flt-1): early diagnosis of vascular endothelial growth factor in breast cancer Biosens","volume":"26","author":"Sezgint\u00fcrk","year":"2011","journal-title":"Bioelectron."},{"key":"bpexab8a75bib113","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2019.111504","type":"journal-article","article-title":"A portable electrochemical immunosensor for highly sensitive point-of-care testing of genetically modified crops Biosens","volume":"142","author":"Gao","year":"2019","journal-title":"Bioelectron."},{"key":"bpexab8a75bib114","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.jcis.2017.09.079","type":"journal-article","article-title":"Electrochemical immunoassay for detection of prostate specific antigen based on peptide nanotube-gold nanoparticle-polyaniline immobilized pencil graphite electrode","volume":"510","author":"Vural","year":"2018","journal-title":"J. Colloid Interface Sci."},{"key":"bpexab8a75bib115","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/macp.201800561","type":"journal-article","article-title":"Progress in the development of intrinsically conducting polymer composites as biosensors","volume":"220","author":"Prajapati","year":"2019","journal-title":"Macromol. Chem. Phys."},{"key":"bpexab8a75bib116","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.bios.2015.07.012","type":"journal-article","article-title":"Ultrasensitive cytosensing based on an aptamer modified nanobiosensor with a bioconjugate: detection of human non-small-cell lung cancer cells Biosens","volume":"74","author":"Mir","year":"2015","journal-title":"Bioelectron."},{"key":"bpexab8a75bib117","doi-asserted-by":"publisher","first-page":"11440","DOI":"10.1038\/srep11440","type":"journal-article","article-title":"Network nanostructured polypyrrole hydrogel\/Au composites as enhanced electrochemical biosensing platform","volume":"5","author":"Rong","year":"2015","journal-title":"Sci. Rep."},{"key":"bpexab8a75bib118","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.bioelechem.2017.12.010","type":"journal-article","article-title":"A new composite consisting of electrosynthesized conducting polymers, graphene sheets and biosynthesized gold nanoparticles for biosensing acute lymphoblastic leukemia","volume":"121","author":"Mazloum-Ardakani","year":"2018","journal-title":"Bioelectrochemistry"}],"container-title":["Biomedical Physics &amp; Engineering Express"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ab8a75","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ab8a75\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ab8a75\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ab8a75","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ab8a75","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ab8a75\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ab8a75\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ab8a75\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ab8a75\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ab8a75\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ab8a75","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ab8a75\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:23:05Z","timestamp":1786796585000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ab8a75"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,30]]},"references-count":118,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,4,30]]},"published-print":{"date-parts":[[2020,5,1]]}},"URL":"https:\/\/doi.org\/10.1088\/2057-1976\/ab8a75","relation":{},"ISSN":["2057-1976"],"issn-type":[{"value":"2057-1976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,30]]},"assertion":[{"value":"Polymeric immunosensors for tumor detection","name":"article_title","label":"Article Title"},{"value":"Biomedical Physics & Engineering Express","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2020 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2019-12-18","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-04-17","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-04-30","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}