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Phys. Eng. Express"],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Poly(lactic acid) (PLA) and poly(\n                    <jats:italic>\u03b5<\/jats:italic>\n                    -caprolactone) (PCL) are two important aliphatic esters known for their biodegradability and bioresorbability properties; the former is stiffer and brittle while the smaller modulus of the latter allows a suitable elongation. The new biomaterials being developed from the blend of these two polymers (PLA and PCL) is opportune due to the reducing interfacial tension between their immiscible phases. In a previous study, PLA\/PCL immiscible blend when compatibilized with poly(\n                    <jats:italic>\u03b5<\/jats:italic>\n                    -caprolactone-\n                    <jats:italic>b<\/jats:italic>\n                    -tetrahydrofuran) resulted in enhanced ductility and toughness no cytotoxic effect in\n                    <jats:italic>vitro<\/jats:italic>\n                    tests. There is little published data on the effect of poly(\n                    <jats:italic>\u03b5<\/jats:italic>\n                    -caprolactone-\n                    <jats:italic>b<\/jats:italic>\n                    -tetrahydrofuran) on PLA and PCL biocompatibility and biodegradability\n                    <jats:italic>in vivo<\/jats:italic>\n                    tests. This study focuses on evaluating the behavioral response and polymer-tissue interaction of compatibilized PLA\/PCL blend compared to neat PLA implanted via intraperitoneal (IP) and subcutaneous (SC) in male Wistar rats, distributed in four experimental groups: neat PLA, PLA\/PCL blend, sham, and control at 2-, 8- and 24-weeks post-implantation (WPI). An open-field test was performed to appraise emotionality and spontaneous locomotor activity. Histopathological investigation using hematoxylin-eosin (H&amp;E) and picrosirius-hematoxylin (PSH) was used to assess polymer-tissue interaction. Modifications in PLA and the PLA\/PCL blend\u2019s surface morphology were determined by scanning electron microscopy (SEM). PLA group defecated more often than PLA\/PCL rats 2 and 8 WPI. Conjunctive capsule development around implants, cell adhesion, angiogenesis, and giant cells of a foreign body to the biomaterial was observed in light microscopy. Both groups displayed a fibrous reaction along with collagen deposition around the biomaterials. In the SEM, the images showed a higher degradation rate for the PLA\/PCL blend in both implantation routes. The polymers implanted via IP exhibited a higher degradation rate compared to SC. These findings emphasize the biocompatibility of the PLA\/PCL blend compatibilized with poly(\n                    <jats:italic>\u03b5<\/jats:italic>\n                    -caprolactone-\n                    <jats:italic>b<\/jats:italic>\n                    -tetrahydrofuran), making this biopolymer an acceptable alternative in a variety of biomedical applications.\n                  <\/jats:p>","DOI":"10.1088\/2057-1976\/abeb5a","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T17:34:48Z","timestamp":1614706488000},"page":"035005","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["<i>In vivo<\/i>\n                    biocompatibility and biodegradability of poly(lactic acid)\/poly(\n                    <i>\u03b5<\/i>\n                    -caprolactone) blend compatibilized with poly(\n                    <i>\u03b5<\/i>\n                    -caprolactone-b-tetrahydrofuran) in Wistar rats"],"prefix":"10.1088","volume":"7","author":[{"given":"Gabriel","family":"Conde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falia Ribeiro Garcia","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula do Patroc\u00ednio","family":"Dias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henriette Gellert","family":"Moranza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Luiz","family":"Montanhim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana de Oliveira","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Aparecido","family":"Chinelatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola Castro","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e3o Roberto","family":"Taboga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Henrique Leal","family":"Bertolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelli In\u00e1cio","family":"Gon\u00e7alves Funnicelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Guariz","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6463-6628","authenticated-orcid":false,"given":"Guilherme de Camargo","family":"Ferraz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"bpexabeb5abib1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.addr.2016.06.014","type":"journal-article","article-title":"Poly(lactic acid) blends in biomedical applications","volume":"107","author":"Saini","year":"2016","journal-title":"Adv. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-10-21","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2021-03-02","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2021-03-15","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}