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Here, the measurement is based on the total optical loss detection when specially fabricated sensor heads were immersed into ACSF solutions with and without different concentrations of A<jats:italic>\u03b2<\/jats:italic>42 biomarkers since the bulk refractive index change was performed. Baseline stability and the reference ring down times of the sensor head were measured in the air as 0.87% and 441.6 <jats:italic>\u03bc<\/jats:italic>s \u00b1 3.9 <jats:italic>\u03bc<\/jats:italic>s, respectively. Afterward, the total optical loss of the system was measured when the sensor head was immersed in deionized water, ACSF solution, and ACSF solutions with A<jats:italic>\u03b2<\/jats:italic>42 in different concentrations. The lowest A<jats:italic>\u03b2<\/jats:italic>42 concentration of 2 ppm was detected by LOR. Results showed that LOR fabricated by single-mode fibers for FLRDS system design are promising candidates to be utilized as fiber optic biosensors after sensor head modification and have a high potential for early detection applications of not only AD but possibly also several fatal diseases such as diabetes and cancer.<\/jats:p>","DOI":"10.1088\/2057-1976\/ad3f1f","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T22:22:54Z","timestamp":1713306174000},"page":"035037","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Application of fiber loop ringdown spectroscopy technique for a new approach to beta-amyloid monitoring for Alzheimer Disease\u2019s early detection"],"prefix":"10.1088","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-6915","authenticated-orcid":true,"given":"Burak Malik","family":"Kaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1543-2223","authenticated-orcid":false,"given":"Semih","family":"Oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6539-4344","authenticated-orcid":false,"given":"Okan","family":"Esenturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"bpexad3f1fbib1","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/nm0706-780","article-title":"Alzheimer disease: progress or profit?","volume":"12","author":"Mount","year":"2006","journal-title":"Nat. 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