{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:04:59Z","timestamp":1792433099899,"version":"4.5.0"},"reference-count":53,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/page\/copyright"},{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LBY22H180008"],"award-info":[{"award-number":["LBY22H180008"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Phys. Eng. Express"],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Extracellular vesicles (EVs) have been recognized as one of the promising specific drugs for myocardial infarction (MI) prognosis. Nevertheless, low intramyocardial retention of EVs remains a major impediment to their clinical application. In this study, we developed a silk fibroin\/hydroxypropyl cellulose (SF\/HPC) composite hydrogel combined with AC16 cell-derived EVs targeted modification by folic acid for the treatment of acute myocardial infarction repair. EVs were functionalized by distearoylphosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG-FA) via noncovalent interaction for targeting and accelerating myocardial infarction\u2002repair. <jats:italic>In vitro<\/jats:italic>, cytocompatibility analyses revealed that the as-prepared hydrogels had excellent cell viability by MTT assay and the functionalized EVs had higher cell migration by scratch assay. <jats:italic>In vivo<\/jats:italic>, the composite hydrogels can promote myocardial tissue repair effects by delaying the process of myocardial fibrosis and promoting angiogenesis of infarct area in MI rat model.<\/jats:p>","DOI":"10.1088\/2057-1976\/ad40b2","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T22:21:06Z","timestamp":1713565266000},"page":"045001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Silk fibroin and hydroxypropyl cellulose composite injectable hydrogel-containing extracellular vesicles for myocardial infarction repair"],"prefix":"10.1088","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6804-0460","authenticated-orcid":false,"given":"Yinjian","family":"Hua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6332-7735","authenticated-orcid":false,"given":"Zhengfei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjie","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linggang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3666-8216","authenticated-orcid":false,"given":"Guohua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"bpexad40b2bib1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jmst.2023.06.005","article-title":"Injectable decellularized extracellular matrix hydrogel loaded with exosomes encapsulating curcumin for prevention of cardiac fibrosis after myocardial infarction","volume":"167","author":"Wang","year":"2023","journal-title":"J. Mater. Sci. Technol."},{"key":"bpexad40b2bib2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104711","article-title":"Novel design of nano-selenium loaded injectable hydrogel combined with mesenchymal stem cells-derived exosomes improving cardiac repair and nursing care after acute myocardial infarction","volume":"87","author":"Lin","year":"2023","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"bpexad40b2bib3","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/s41392-022-00925-z","article-title":"Signaling pathways and targeted therapy for myocardial infarction","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal. Transduction. Targeted. Ther."},{"key":"bpexad40b2bib4","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.bioactmat.2023.07.007","article-title":"An injectable conductive hydrogel with dual responsive release of rosmarinic acid improves cardiac function and promotes repair after myocardial infarction","volume":"29","author":"Zhang","year":"2023","journal-title":"Bioact. Mater."},{"key":"bpexad40b2bib5","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.bioactmat.2023.03.023","article-title":"Cardiac patches made of brown adipose-derived stem cell sheets and conductive electrospun nanofibers restore infarcted heart for ischemic myocardial infarction","volume":"27","author":"Wei","year":"2023","journal-title":"Bioact. Mater."},{"key":"bpexad40b2bib6","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301010","article-title":"Clinical translation of extracellular vesicles","volume":"12","author":"Ghodasara","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"bpexad40b2bib7","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jconrel.2023.07.059","article-title":"Extracellular vesicle-embedded materials","volume":"361","author":"Ma","year":"2023","journal-title":"J. Controlled Release"},{"key":"bpexad40b2bib8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108352","article-title":"Extracellular vesicle-based therapeutics: extracellular vesicles as therapeutic targets and agents","volume":"242","author":"Takahashi","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"bpexad40b2bib9","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.actbio.2023.08.022","article-title":"Targeted heart repair by T\u03b24-loaded cardiac-resident macrophage-derived extracellular vesicles modified with monocyte membranes","volume":"169","author":"Chen","year":"2023","journal-title":"Acta Biomater."},{"key":"bpexad40b2bib10","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/s41419-020-2508-y","article-title":"Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis","volume":"11","author":"Wu","year":"2020","journal-title":"Cell. Death. Dis."},{"key":"bpexad40b2bib11","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1038\/s41467-023-37832-y","article-title":"Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice","volume":"14","author":"Yu","year":"2023","journal-title":"Nat. Commun."},{"key":"bpexad40b2bib12","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.jconrel.2023.01.060","article-title":"Injectable hydrogels for sustained delivery of extracellular vesicles in cartilage regeneration","volume":"355","author":"Van de Looij","year":"2023","journal-title":"J. Controlled Release"},{"key":"bpexad40b2bib13","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.actbio.2021.03.030","article-title":"3D encapsulation and tethering of functionally engineered extracellular vesicles to hydrogels","volume":"126","author":"Huang","year":"2021","journal-title":"Acta Biomater."},{"key":"bpexad40b2bib14","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202214468","article-title":"YAP-suppressive nanodrug crosslinked self-immunoregulatory polysaccharide injectable hydrogel for attenuating cardiac fibrosis to treat myocardial infarction","volume":"33","author":"Sun","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"bpexad40b2bib15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122088","article-title":"Injectable polyaniline nanorods\/alginate hydrogel with AAV9-mediated VEGF overexpression for myocardial infarction treatment","volume":"296","author":"Wu","year":"2023","journal-title":"Biomaterials"},{"key":"bpexad40b2bib16","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301244","article-title":"Extracellular matrix\/glycopeptide hybrid hydrogel as an immunomodulatory niche for endogenous cardiac repair after myocardial infarction","volume":"10","author":"Kong","year":"2023","journal-title":"Adv. Sci."},{"key":"bpexad40b2bib17","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/adhm.201200097","article-title":"Silk fibroin in tissue engineering","volume":"1","author":"Kasoju","year":"2012","journal-title":"Adv. Healthcare Mater."},{"key":"bpexad40b2bib18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121008","article-title":"Conductive polypyrrole-encapsulated silk fibroin fibers for cardiac tissue engineering","volume":"276","author":"Liang","year":"2021","journal-title":"Biomaterials"},{"key":"bpexad40b2bib19","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301310","article-title":"Injectable sealants based on silk fibroin for fast hemostasis and wound repairing","volume":"12","author":"Zhao","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"bpexad40b2bib20","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3390\/gels8080519","article-title":"Hydroxypropyl cellulose\/pluronic-based composite hydrogels as biodegradable mucoadhesive scaffolds for tissue engineering","volume":"8","author":"Filip","year":"2022","journal-title":"Gels"},{"key":"bpexad40b2bib21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413208","article-title":"Influence of injection application on the sol-gel phase transition conditions of polysaccharide-based hydrogels","volume":"22","author":"Ryl","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"bpexad40b2bib22","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2020.113591","article-title":"Structural and therapeutic properties of curcumin solubilized pluronic F127 micellar solutions and hydrogels","volume":"314","author":"Ganguly","year":"2020","journal-title":"J. Mol. Liq."},{"key":"bpexad40b2bib23","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c04686","article-title":"Islet-1 mesenchymal stem cells-derived exosome-incorporated angiogenin-1 hydrogel for enhanced acute myocardial infarction therapy","volume":"14","author":"Hu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bpexad40b2bib24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.127423","article-title":"An injectable hydrogel based on phenylboronic acid hyperbranched macromer encapsulating gold nanorods and astragaloside IV nanodrug for myocardial infarction","volume":"413","author":"Chen","year":"2021","journal-title":"Chem. Eng. J."},{"key":"bpexad40b2bib25","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202200971","article-title":"A pH\/H2O2\/MMP9 time-response gel system with sparchigh tregs derived extracellular vesicles promote recovery after acute myocardial infarction","volume":"11","author":"Cheng","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"bpexad40b2bib26","doi-asserted-by":"publisher","first-page":"6740","DOI":"10.7150\/thno.75899","article-title":"Multiplexed strategies toward clinical translation of extracellular vesicles","volume":"12","author":"Song","year":"2022","journal-title":"Theranostics"},{"key":"bpexad40b2bib27","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1038\/s41556-022-00983-z","article-title":"Opportunities and challenges in studying the extracellular vesicle corona","volume":"24","author":"Buzas","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"bpexad40b2bib28","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1002\/med.21918","article-title":"Extracellular vesicles: emerging frontiers in wound healing","volume":"42","author":"Hade","year":"2022","journal-title":"Med. Res. Rev."},{"key":"bpexad40b2bib29","doi-asserted-by":"publisher","first-page":"3192","DOI":"10.1182\/blood.2019004119","article-title":"Platelets and extracellular vesicles and their cross talk with cancer","volume":"137","author":"Lazar","year":"2021","journal-title":"Blood"},{"key":"bpexad40b2bib30","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s13238-021-00863-6","article-title":"The mini player with diverse functions: extracellular vesicles in cell biology, disease, and therapeutics","volume":"13","author":"Thakur","year":"2022","journal-title":"Protein & Cell"},{"key":"bpexad40b2bib31","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s12964-023-01103-6","article-title":"A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication","volume":"21","author":"Liu","year":"2023","journal-title":"Cell Commun Signal"},{"key":"bpexad40b2bib32","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s13287-022-02806-2","article-title":"Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context","volume":"13","author":"Esmaeili","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"bpexad40b2bib33","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1481321","article-title":"Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing","volume":"7","author":"Buschmann","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"bpexad40b2bib34","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jconrel.2019.08.021","article-title":"Folate-displaying exosome mediated cytosolic delivery of siRNA avoiding endosome trapping","volume":"311","author":"Zheng","year":"2019","journal-title":"J. Controlled Release"},{"key":"bpexad40b2bib35","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.bioactmat.2020.09.014","article-title":"Folic acid-modified exosome-PH20 enhances the efficiency of therapy via modulation of the tumor microenvironment and directly inhibits tumor cell metastasis","volume":"6","author":"Feng","year":"2021","journal-title":"Bioact. Mater."},{"key":"bpexad40b2bib36","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jiec.2020.03.034","article-title":"Effect of gelatin on dimensional stability of silk fibroin hydrogel structures fabricated by digital light processing 3D printing","volume":"89","author":"Lee","year":"2020","journal-title":"J. Ind. Eng. Chem."},{"key":"bpexad40b2bib37","doi-asserted-by":"publisher","first-page":"16234","DOI":"10.1021\/acsnano.2c05168","article-title":"An intrapericardial injectable hydrogel patch for mechanical-electrical coupling with infarcted myocardium","volume":"16","author":"Yu","year":"2022","journal-title":"Acs Nano"},{"key":"bpexad40b2bib38","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1186\/s12951-023-02063-2","article-title":"Application of biomedical materials in the diagnosis and treatment of myocardial infarction","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"bpexad40b2bib39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.134450","article-title":"V1-Cal hydrogelation enhances its effects on ventricular remodeling reduction and cardiac function improvement post myocardial infarction","volume":"433","author":"Wang","year":"2022","journal-title":"Chem. Eng. J."},{"key":"bpexad40b2bib40","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302280","article-title":"Cellular uptake of engineered extracellular vesicles: biomechanisms, engineered strategies, and disease treatment","volume":"13","author":"Xie","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"bpexad40b2bib41","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300319","article-title":"A Comparison of cellular uptake mechanisms, delivery efficacy, and intracellular fate between liposomes and extracellular vesicles","volume":"12","author":"Gandek","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"bpexad40b2bib42","doi-asserted-by":"publisher","first-page":"2826","DOI":"10.1016\/j.biomaterials.2009.01.040","article-title":"Silk fibroin\/polyacrylamide semi-interpenetrating network hydrogels for controlled drug release","volume":"30","author":"Mandal","year":"2009","journal-title":"Biomaterials"},{"key":"bpexad40b2bib43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2023.138573","article-title":"Maximizing the benefits of combining fibroin and sericin: functionalized obsoleted silk cocoon shell for purifying oily wastewater containing Pb2+","volume":"422","author":"Ding","year":"2023","journal-title":"J. Cleaner Prod."},{"key":"bpexad40b2bib44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120855","article-title":"An injectable peptide hydrogel with excellent self-healing ability to continuously release salvianolic acid B for myocardial infarction","volume":"274","author":"Chen","year":"2021","journal-title":"Biomaterials"},{"key":"bpexad40b2bib45","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jmst.2022.11.002","article-title":"An injectable alginate\/fibrin hydrogel encapsulated with cardiomyocytes and VEGF for myocardial infarction treatment","volume":"143","author":"Liu","year":"2023","journal-title":"J. Mater. Sci. Technol."},{"key":"bpexad40b2bib46","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2022.109941","article-title":"Preservation of cardiac functions post myocardial infarction in vivo by a phenylboric acid-grafted hyaluronic hydrogel with anti-oxidation and accelerated degradation under oxidative microenvironment","volume":"238","author":"Wang","year":"2022","journal-title":"Compos. Part B-eng."},{"key":"bpexad40b2bib47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.145878","article-title":"An injectable ECM-like hydrogel with bioactive peptides and RepSox nanoparticles for myocardial infarction treatment","volume":"474","author":"Wang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"bpexad40b2bib48","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s00395-019-0728-z","article-title":"Exogenous GDF11 attenuates non-canonical TGF-signaling to protect the heart from acute myocardial ischemia-reperfusion injury","volume":"114","author":"Su","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"bpexad40b2bib49","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154849","article-title":"Dengzhan shengmai capsule attenuates cardiac fibrosis in post-myocardial infarction rats by regulating LTBP2 and TGF-\u03b21\/Smad3 pathway","volume":"116","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"key":"bpexad40b2bib50","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2023.152102","article-title":"MiR-223-3p overexpressed adipose mesenchymal stem cell-derived exosomes promote wound healing via targeting MAPK10","volume":"125","author":"Liu","year":"2023","journal-title":"Acta Histochem."},{"key":"bpexad40b2bib51","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12951-021-00894-5","article-title":"Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis","volume":"19","author":"Hu","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"bpexad40b2bib52","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002757","article-title":"Elevated plasma von willebrand factor antigen and activity levels are associated with the severity of coronary stenosis clinical and applied","volume":"26","author":"Yan","year":"2020","journal-title":"Clin. Appl. Thromb-Hem."},{"key":"bpexad40b2bib53","doi-asserted-by":"publisher","first-page":"2496","DOI":"10.1097\/CM9.0000000000002757","article-title":"SENP2-mediated SERCA2a desumoylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia\/reperfusion injury","volume":"136","author":"Luo","year":"2023","journal-title":"Chin. Med. J."}],"container-title":["Biomedical Physics &amp; Engineering Express"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ad40b2","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ad40b2\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ad40b2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ad40b2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ad40b2\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ad40b2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ad40b2\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ad40b2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T15:43:22Z","timestamp":1749915802000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2057-1976\/ad40b2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":53,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4,30]]},"published-print":{"date-parts":[[2024,7,1]]}},"URL":"https:\/\/doi.org\/10.1088\/2057-1976\/ad40b2","relation":{},"ISSN":["2057-1976"],"issn-type":[{"value":"2057-1976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,30]]},"assertion":[{"value":"Silk fibroin and hydroxypropyl cellulose composite injectable hydrogel-containing extracellular vesicles for myocardial infarction repair","name":"article_title","label":"Article Title"},{"value":"Biomedical Physics & Engineering Express","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2024 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2023-12-16","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-04-19","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-04-30","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}