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These scaffolds, prepared via cryogelation, are capable of flowing through surgical needles in both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> conditions, and promptly regain their original shape. Modification with poly(L-lysine) (PLL) enables lentivirus immobilization while interconnected macroporous structure allows cell infiltration into these matrices, thereby facilitating cell-virus interaction over a large surface area for efficient transduction. Notably, these preformed injectable scaffolds demonstrate hemocompatibility, cell viability and minimally inflammatory response as shown by our <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> studies involving histology and immunophenotyping of infiltrating cells. This study marks the first instance of using preformed injectable scaffolds for delivery of lentivectors, which offers a non-invasive and localized approach for delivery of factors enabling <jats:italic>in situ<\/jats:italic> lentiviral transduction suitable for both tissue engineering and immunotherapeutic applications.<\/jats:p>","DOI":"10.1088\/2057-1976\/ad4e3a","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T22:20:27Z","timestamp":1716330027000},"page":"045039","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Surface-modified injectable poly(ethylene-glycol) diacrylate-based cryogels for localized gene delivery"],"prefix":"10.1088","volume":"10","author":[{"given":"Neha","family":"Dalal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiren","family":"Dandia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Ingle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4056-2628","authenticated-orcid":false,"given":"Prakriti","family":"Tayalia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"bpexad4e3abib1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41392-021-00487-6.","article-title":"Viral vector platforms within the gene therapy landscape","volume":"6","author":"Bulcha","year":"2021","journal-title":"Signal Transduct. 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