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The cytotoxicity profile of PEGylated Pt NPs was assessed on a normal cell line (L929) and a breast cancer cell line (MCF-7) using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The results revealed an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 79.18 \u03bcg ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    on the cancer cell line and non-toxic behaviour on the normal cell line. In the dual staining apoptosis assay, it was observed that the mortality of cells cultured in conjunction with platinum nanoparticles intensified and the proliferative activity of MCF-7 cells gradually diminished over time in correlation with the increasing concentration of the PEGylated Pt NPs sample. The\n                    <jats:italic>in vitro<\/jats:italic>\n                    DCFH-DA assay for oxidative stress assessment in nanoparticle-treated cells unveiled the mechanistic background of the anticancer activity of PEGylated platinum nanoparticles as ROS-assisted mitochondrial dysfunction.\n                  <\/jats:p>","DOI":"10.1088\/2057-1976\/ad795d","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T18:48:16Z","timestamp":1726080496000},"page":"065019","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessing anticancer properties of PEGylated platinum nanoparticles on human breast cancer cell lines using in-vitro assays"],"prefix":"10.1088","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3949-3925","authenticated-orcid":false,"given":"Felicia Aswathy","family":"W","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5078-5420","authenticated-orcid":false,"given":"Jiya","family":"Jose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7975-3659","authenticated-orcid":false,"given":"Anila","family":"E I","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"bpexad795dbib1","doi-asserted-by":"publisher","first-page":"1\u201314","DOI":"10.1155\/2022\/2444516","article-title":"Recent advances in the development of noble metal NPs for cancer therapy","volume":"2022","author":"Zhao","year":"2022","journal-title":"Bioinorg. 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