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Phys. Eng. Express"],"published-print":{"date-parts":[[2025,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Elevated intraocular pressure is a key pathogenic factor in glaucoma, often leading to irreversible vision loss. In previous studies, we developed a novel hollow mesoporous organosilica nanocarrier functionalized with manganese(III) tetrakis(1-methyl-4-pyridyl)porphyrin (HMMN), demonstrating superior efficacy in treating primary open-angle glaucoma. This study presents a comparative analysis of the transcorneal permeability of HMMNs modified with thioether, biphenyl, and thioether\/phenylene moieties in the porcine eye. Transcorneal permeability was evaluated using fluorescence intensity measurements in the porcine aqueous humor, followed by the calculation of diffusion and apparent permeability coefficient<jats:strike>s<\/jats:strike> (Papp). Results reveal that thioether-modified HMMN exhibits significantly enhanced corneal permeability compared to biphenyl and thioether\/phenylene-modified variants, with a diffusion coefficient of 4.88\u00a0\u00d7\u00a010<jats:sup>\u22126<\/jats:sup> cm<jats:sup>2<\/jats:sup> s<jats:sup>\u22121<\/jats:sup> and a Papp of 1.30\u00a0\u00d7\u00a010<jats:sup>\u20135<\/jats:sup> cm s<jats:sup>\u22121<\/jats:sup> in the porcine eye. These findings provide valuable insights into the permeability properties of hollow mesoporous organosilica nanocarriers, positioning them for broader applications in the treatment of various ocular diseases and potentially beyond. Furthermore, this work serves as a valuable reference for future studies exploring the potential of hybridized hollow mesoporous organosilica nanoparticles functionalized with diverse organic moieties for enhanced therapeutic outcomes.<\/jats:p>","DOI":"10.1088\/2057-1976\/ade0c3","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T22:47:43Z","timestamp":1749077263000},"page":"045015","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Permeation dynamics of organic moiety-tuned organosilica nanoparticles across porcine corneal barriers: experimental and mass transfer analysis for glaucoma drug delivery"],"prefix":"10.1088","volume":"11","author":[{"given":"Yifan","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengjun","family":"Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongguang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maomao","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9275-8887","authenticated-orcid":true,"given":"Yonghui","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"bpexade0c3bib1","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1016\/S0140-6736(23)01289-8","article-title":"Glaucoma: now and beyond","volume":"402","author":"Jayaram","year":"2023","journal-title":"Lancet"},{"key":"bpexade0c3bib2","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12886-022-02374-2","article-title":"The ocular biometry characteristics of young patients with primary angle-closure glaucoma","volume":"22","author":"Xu","year":"2022","journal-title":"BMC Ophthalmol"},{"key":"bpexade0c3bib3","doi-asserted-by":"publisher","first-page":"S341","DOI":"10.4103\/IJO.IJO_2797_24","article-title":"Double-frequency Nd:YAG laser reduction of peripheral iridotomy size for treatment of visual symptoms","volume":"73","author":"Kumar","year":"2025","journal-title":"Indian Journal of Ophthalmology"},{"key":"bpexade0c3bib4","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1002\/lsm.23783","article-title":"Evaluating the effect of pulse energy on femtosecond laser trabeculotomy (FLT) outflow channels for glaucoma treatment in human cadaver eyes","volume":"56","author":"Luo","year":"2024","journal-title":"Lasers in Surgery and Medicine"},{"key":"bpexade0c3bib5","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.3390\/jcm10153307","article-title":"Selective laser trabeculoplasty in the treatment of ocular hypertension and open-angle glaucoma: clinical review","volume":"10","author":"Zgry\u017aniak","year":"2021","journal-title":"Journal of Clinical Medicine"},{"key":"bpexade0c3bib6","doi-asserted-by":"publisher","first-page":"274","DOI":"10.3390\/pharmaceutics16020274","article-title":"Chemical insights into topical agents in intraocular pressure management: from glaucoma etiopathology to therapeutic approaches","volume":"16","author":"Patton","year":"2024","journal-title":"Pharmaceutics"},{"key":"bpexade0c3bib7","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.3390\/polym14122359","article-title":"Intravitreal Injectable hydrogels for sustained drug delivery in glaucoma treatment and therapy","volume":"14","author":"Akulo","year":"2022","journal-title":"Polymers"},{"key":"bpexade0c3bib8","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.3390\/pharmaceutics14061150","article-title":"Novel eye drop delivery systems: advance on formulation design strategies targeting anterior and posterior segments of the eye","volume":"14","author":"Wang","year":"2022","journal-title":"Pharmaceutics"},{"key":"bpexade0c3bib9","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3390\/jcm12010151","article-title":"Devices and treatments to address low adherence in glaucoma patients: a narrative review","volume":"12","author":"Cvenkel","year":"2022","journal-title":"JCM"},{"key":"bpexade0c3bib10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102951","article-title":"Formulation, characterization, optimization and in-vivo evaluation of methazolamide liposomal in situ gel for treating glaucoma","volume":"67","author":"Londhe","year":"2022","journal-title":"J. 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