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Phys. Eng. Express"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Parkinson\u2019s disease (PD) is the second most common progressive neurodegenerative disorder, characterized by both motor and non-motor symptoms. In this study, we conducted a meta-analysis of gene expression profiles from four GEO datasets (comprising 59 PD patients and 41 participants control) to identify consistently differentially expressed messenger ribonucleic acids (DEmRNAs). We identified 5,495 down-regulated and 9,850 up-regulated DEmRNAs, of which 64 and 25, respectively, were common across all datasets. Functional enrichment analysis revealed that down-regulated DEmRNAs were primarily enriched in pathways related to neurotransmitter transport, dopamine biosynthesis, and dopaminergic synapse function, while up-regulated DEmRNAs were linked to cell cycle regulation and PI3K-Akt signaling. Notably, dysregulation of key genes, including SNCA (encoding\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -synuclein), SLC6A3, TUBB, TUBB3, TUBB4B, and NDUFA9, were associated with PD as well as other neurodegenerative disorders, such as Alzheimer\u2019s, Huntington\u2019s, and Prion diseases. These DEmRNAs and pathways may offer potential biomarkers and therapeutic targets for PD and related neurological disorders.\n                  <\/jats:p>","DOI":"10.1088\/2057-1976\/ae1a8a","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T22:47:40Z","timestamp":1762210060000},"page":"015041","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Meta-analysis of mRNA dysregulation associated with Parkinson\u2019s disease and other neurological disorders"],"prefix":"10.1088","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1547-3694","authenticated-orcid":true,"given":"Tun","family":"Lin Aung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye Win","family":"Aung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4882-078X","authenticated-orcid":true,"given":"Xiaoran","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"bpexae1a8abib1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/mds.10305","type":"journal-article","article-title":"Systematic review of incidence studies of Parkinson\u2019s disease","volume":"18","author":"Twelves","year":"2003","journal-title":"Movement Disorders"},{"key":"bpexae1a8abib2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1136\/bmj.321.7252.21","type":"journal-article","article-title":"Cross sectional prevalence survey of idiopathic Parkinson\u2019s disease and Parkinsonism in London","volume":"321","author":"Schrag","year":"2000","journal-title":"Brit. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2025-04-09","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-11-03","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-01-06","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}