{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:16:35Z","timestamp":1770264995976,"version":"3.49.0"},"reference-count":14,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":3,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100008328","name":"Marshallplan-Jubil\u00e4umsstiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008328","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Phys. Eng. Express"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction.<\/jats:italic>\n                    Focal cortical dysplasia type II (FCD II) is a significant cause of drug-resistant epilepsy, and the full surgical resection of the lesion is linked with excellent disease-free outcomes. Its imaging hallmark is the white matter hyperintense funnel-shaped transmantle sign on T2-FLAIR magnetic resonance imaging (MRI). Manual delineation of this abnormality is challenging and inconsistent. Most current artificial intelligence (AI) segmentation tools focus on cortical features and do not fully evaluate the white matter component. We tested whether integrating an algorithm trained on white matter lesions may improve FCD II segmentation.\n                    <jats:italic>Methods.<\/jats:italic>\n                    We evaluated the combination of two AI algorithms, MELD Graph (surface-based FCD segmentation) and MindGlide (whole-brain\/white-matter lesion segmentation tool) in 49 FCD cases with a radiologically confirmed transmantle sign. Segmentation accuracy was assessed against expert manual annotations using the Dice similarity coefficient and segmentation volumes.\n                    <jats:italic>Results.<\/jats:italic>\n                    MELD Graph detected the lesion in 31 cases, 22 of which had the transmantle sign included in the expert lesion mask. Among these, MindGlide detected the transmantle sign in eight cases (36%). The mean added Dice score was 0.033 (95% CI, 0.013\u20130.056). Overall Dice values of MELD Graph were 0.321 and increased to 0.354 with the addition of MindGlide. It also contributed additional lesion volume in these eight cases, ranging from 0.028 to 4.18 cm\n                    <jats:sup>3<\/jats:sup>\n                    , with a mean added volume of 0.77 cm\n                    <jats:sup>3<\/jats:sup>\n                    .\n                    <jats:italic>Discussion.<\/jats:italic>\n                    Despite not being trained on FCD data, MindGlide, when combined with MELD Graph, provided a modest improvement in FCD II segmentation, including the deep white matter component of the lesion that is not captured by MELD Graph.\n                    <jats:italic>Conclusion.<\/jats:italic>\n                    These findings provide preliminary evidence supporting the consideration of a sequential cortical and white matter segmentation approach in FCD II, which may guide further epilepsy-specific AI model development.\n                  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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2025-12-02","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-01-26","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-02-04","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}