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Phys. Eng. Express"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Background.<\/jats:italic>\n                    Abdominal wall defects represent a significant surgical challenge due to their potential for serious complications such as herniation, adhesion, and infection. Biomaterials have emerged as viable options for reconstruction, with biological membranes showing promising biocompatibility and reduced inflammatory responses compared to synthetic meshes. However, infection risk remains a major concern, especially due to biofilm formation on implanted materials.\n                    <jats:italic>Objective.<\/jats:italic>\n                    This study aimed to evaluate the inflammatory response, biomechanical performance, and histological characteristics of decellularized bovine pericardium membranes\u2014enriched with vancomycin or amikacin\u2014in comparison to unenriched membranes and synthetic polypropylene mesh for abdominal wall repair in Wistar rats.\n                    <jats:italic>Methods.<\/jats:italic>\n                    Sixty-four Wistar rats were randomly allocated into four groups (\n                    <jats:italic>n<\/jats:italic>\n                    = 16 each): Group I received vancomycin-enriched membranes; Group II, amikacin-enriched membranes; Group III, unenriched decellularized membranes; and Group IV, polypropylene mesh. Animals were euthanized on postoperative days 7 and 21. Hematological analyses were performed, and macroscopic, biomechanical, and histological evaluations were conducted to assess inflammation, tensile strength, and tissue integration.\n                    <jats:italic>Results.<\/jats:italic>\n                    Vancomycin and amikacin-enriched membranes showed reduced inflammatory infiltrates and better vascularized integration compared to the synthetic mesh group. Tensile strength was highest in the polypropylene group, but enriched biological membranes presented satisfactory mechanical resistance. Macroscopically, fewer adhesions were observed in Groups I and II. Histologically, Groups I and II demonstrated more organized tissue remodeling and reduced inflammatory markers.\n                  <\/jats:p>","DOI":"10.1088\/2057-1976\/ae6e45","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:47:54Z","timestamp":1778885274000},"page":"035042","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibiotic-enriched decellularized bovine pericardium for abdominal wall repair in rats: evaluation of inflammatory response and mechanical strength"],"prefix":"10.1088","volume":"12","author":[{"given":"Thais Andrade Costa","family":"Casagrande","sequence":"first","affiliation":[{"name":"Universidade Positivo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eduarda Ferreira","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Universidade Positivo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana de Jesus","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Universidade Positivo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6174-683X","authenticated-orcid":true,"given":"Paula Kastrup Carneiro","family":"Bond","sequence":"additional","affiliation":[{"name":"Universidade Positivo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Tucholski","family":"Roque","sequence":"additional","affiliation":[{"name":"Universidade Positivo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danieli Zanoni","family":"Cypriano","sequence":"additional","affiliation":[{"name":"Universidade Positivo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Ramos","family":"Dantas","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Infectious Diseases, School of Medicine, Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Henrique","family":"Loesch","sequence":"additional","affiliation":[{"name":"Florida Christian University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00edra de Mayo Oliveira Nogueira","family":"Loesch","sequence":"additional","affiliation":[{"name":"Florida Christian University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo de Paula","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Universidade Positivo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3471-1786","authenticated-orcid":true,"given":"Felipe Francisco","family":"Tuon","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Infectious Diseases, School of Medicine, Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"bpexae6e45bib1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1055\/s-0038-1661381","type":"journal-article","article-title":"Flap reconstruction of the abdominal wall","volume":"32","author":"Roubaud","year":"2018","journal-title":"Semin. 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