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Express"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This Monte Carlo study investigated a dual-head SPECT-based system for prompt-gamma (PG) range verification in proton therapy, focusing on energy-window and collimator septal thickness effects on PG emission profiles and distal dose fall-off. Using GATE, correlations between PG emissions (4.44, 5.24, 6.13 MeV) and proton depth\u2013dose distributions were evaluated for 90\u2013180 MeV beams in a PMMA phantom. Narrow (4.2\u20134.6, 5.0\u20135.4, 5.9\u20136.3 MeV) and broad (4.2\u20136.3 MeV) windows were studied. A dual-head SPECT with parallel-hole collimator (1\u20135 mm septa) was simulated. Image reconstruction was performed with FBP and with OSEM including attenuation correction, using STIR 6.2. The 5.9\u20136.3 MeV window showed the highest spatial correlation with proton range (\u0394 \u22481 mm), but its low yield limited applicability. The 4.2\u20134.6 and 4.2\u20136.3 MeV windows balanced detection yield and accuracy (\u0394 \u22482\u20133 mm). Septal thicknesses \u2a7e4 mm produced shadowing artefacts, whereas 3 mm gave the most accurate PG localization for the 90 MeV proton beam studied. For the 4.2\u20134.6 and 4.2\u20136.3 MeV windows, the PG localization errors (relative to the true PG emission profile) were 1.5 \u00b1 0.5 and 1.4 \u00b1 0.4 mm with FBP, and 1.9 \u00b1 0.3 and 1.7 \u00b1 0.4 mm with OSEM, despite \u223c20% lower PG yield than the 1 mm septum. Overall, appropriate window and septal thickness provided PG localization accuracy of 1\u20132 mm. A 3 mm septum with either the 4.2\u20134.6 or 4.2\u20136.3 MeV window offers a favourable trade-off between spatial accuracy and detection efficiency under the 90 MeV condition investigated here, highlighting the potential of optimized SPECT systems for proton range monitoring at this energy.<\/jats:p>","DOI":"10.1088\/2057-1976\/aeae43","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:48:48Z","timestamp":1790808528000},"page":"055044","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimization of selected SPECT system parameters for proton range verification: a Monte Carlo study"],"prefix":"10.1088","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5384-9534","authenticated-orcid":true,"given":"S","family":"Gharib","sequence":"first","affiliation":[{"name":"University of Guilan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9246-6219","authenticated-orcid":true,"given":"P","family":"Taherparvar","sequence":"additional","affiliation":[{"name":"University of Guilan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"266","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"bpexaeae43bib1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radphyschem.2024.112164","type":"journal-article","article-title":"Feasibility of the compton suppressed gamma-ray spectrometry for proton therapy applications","volume":"226","author":"Tabrizi","year":"2025","journal-title":"Radiat. 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