{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T21:34:32Z","timestamp":1787693672630,"version":"build-2784847793"},"reference-count":82,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Prog. Biomed. Eng."],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Retinal implantation of an electrode array is an emerging treatment for vision loss caused by outer-retinal degeneration. This article collects and analyses harms associated with the treatment reported in the peer-reviewed literature, thus enabling informed decision-making by patients, clinicians, researchers, engineers, and policymakers. We searched MEDLINE, Embase, and clinical trials registries for peer-reviewed journal articles reporting harms outcomes. We extracted data from articles including study design, definitions of \u2018serious adverse event\u2019, and timing of adverse events. We applied the McMaster tool to these articles to assess the risk of bias in harms assessment and reporting. Our searches returned 585 abstracts. We reviewed the full text of 59 articles describing 11 different devices. McMaster scores ranged from 3 to 12 (maximum 15; higher scores indicate less risk). We compiled a comprehensive list of all serious and non-serious adverse events associated with retinal implantation. Several harms were common across devices. Our meta-analysis showed that serious adverse events are log-uniformly distributed throughout follow-up. Improved reporting and further clinical studies are needed to develop a reliable safety profile of retinal implantation. Our findings will help guide the design, conduct, and reporting of future clinical trials of retinal implantation and other emerging treatments for vision loss. (PROSPERO registration: CRD42022308123.)<\/jats:p>","DOI":"10.1088\/2516-1091\/ad811e","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T23:06:43Z","timestamp":1727478403000},"page":"012001","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Harms associated with retinal implantation of a stimulating electrode array to treat outer-retinal degeneration: a systematic review and meta-analysis of safety"],"prefix":"10.1088","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8184-1703","authenticated-orcid":true,"given":"Luke E","family":"Hallum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7679-1764","authenticated-orcid":true,"given":"Shaun L","family":"Cloherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"prgbad811ebib1","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","article-title":"Retinitis pigmentosa","volume":"368","author":"Hartong","year":"2006","journal-title":"Lancet"},{"key":"prgbad811ebib2","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1750-1172-1-40","article-title":"Retinitis pigmentosa","volume":"1","author":"Hamel","year":"2006","journal-title":"Orphanet J. Rare Dis."},{"key":"prgbad811ebib3","doi-asserted-by":"publisher","first-page":"4982","DOI":"10.1167\/iovs.09-3639","article-title":"Relationship between RPE and choriocapillaris in age-related macular degeneration","volume":"50","author":"McLeod","year":"2009","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"prgbad811ebib4","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/0002-9394(84)90636-6","article-title":"Prevalence of retinitis pigmentosa in Maine","volume":"97","author":"Bunker","year":"1984","journal-title":"Am J. Ophthalmol."},{"key":"prgbad811ebib5","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/j.1399-0004.1987.tb02804.x","article-title":"Estimation of prognosis and prevalence of retinitis pigmentosa and Usher syndrome in Norway","volume":"31","author":"Gr\u00f8ndahl","year":"1987","journal-title":"Clin. Genet."},{"key":"prgbad811ebib6","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1001\/jamaophthalmol.2022.4401","article-title":"Prevalence of age-related macular degeneration in the US in 2019","volume":"140","author":"Rein","year":"2022","journal-title":"JAMA Ophthalmol."},{"key":"prgbad811ebib7","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob. Health"},{"key":"prgbad811ebib8","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1001\/archopht.1992.01080230134038","article-title":"Morphometric analysis of macular photoreceptors and ganglion cells in retinas with retinitis pigmentosa","volume":"110","author":"Stone","year":"1992","journal-title":"Arch. Ophthalmol."},{"key":"prgbad811ebib9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1146\/annurev-vision-111815-114425","article-title":"Electrical stimulation of the retina to produce artificial vision","volume":"2","author":"Weiland","year":"2016","journal-title":"Annu. Rev. Vis. Sci."},{"key":"prgbad811ebib10","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.clinph.2019.11.029","article-title":"An update on retinal prostheses","volume":"131","author":"Ayton","year":"2020","journal-title":"Clin. Neurophysiol."},{"key":"prgbad811ebib11","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1167\/tvst.10.10.8","article-title":"Retinal implantation of electronic vision prostheses to treat retinitis pigmentosa: a systematic review","volume":"10","author":"Hallum","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"key":"prgbad811ebib12","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1167\/tvst.9.8.25","article-title":"Harmonization of outcomes and vision endpoints in vision restoration trials: Recommendations from the international hover taskforce","volume":"9","author":"Ayton","year":"2020","journal-title":"Transl. Vis. Sci. Technol."},{"key":"prgbad811ebib13","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/hir.12260","article-title":"The development of search filters for adverse effects of medical devices in MEDLINE and EMBASE","volume":"36","author":"Golder","year":"2019","journal-title":"Health Inf. Libr. J."},{"key":"prgbad811ebib14","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1001\/jamaoto.2013.1744","article-title":"Cochlear implantation in adults: a systematic review and meta-analysis","volume":"139","author":"Gaylor","year":"2013","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"prgbad811ebib15","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.jclinepi.2008.06.007","article-title":"AHRQ series paper 4: assessing harms when comparing medical interventions: AHRQ and the effective health-care program","volume":"63","author":"Chou","year":"2010","journal-title":"J. Clin. Epidemiol."},{"key":"prgbad811ebib16","author":"Higgins","year":"2019","edition":"2nd edn"},{"key":"prgbad811ebib17","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"151","author":"PRISMA Group","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"prgbad811ebib18","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1016\/j.ophtha.2016.06.049","article-title":"Five-year safety and performance results from the Argus II retinal prosthesis system clinical trial","volume":"123","author":"da Cruz","year":"2016","journal-title":"Ophthalmology"},{"key":"prgbad811ebib19","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.oret.2017.08.010","article-title":"Adapted surgical procedure for Argus II retinal implantation: feasibility, safety, efficiency and postoperative anatomic findings","volume":"2","author":"Delyfer","year":"2018","journal-title":"Ophthalmol. Retina"},{"key":"prgbad811ebib20","doi-asserted-by":"publisher","first-page":"e1212","DOI":"10.1111\/aos.14728","article-title":"Improved performance and safety from Argus II retinal prosthesis post-approval study in France","volume":"99","author":"Delyfer","year":"2021","journal-title":"Acta Ophthalmol."},{"key":"prgbad811ebib21","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1007\/s00417-012-2210-6","article-title":"Emotional wellbeing of blind patients in a pilot trial with subretinal implants","volume":"251","author":"Peters","year":"2013","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"prgbad811ebib22","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1136\/bjo.2007.131961","article-title":"Extraocular surgery for implantation of an active subretinal visual prosthesis with external connections: feasibility and outcome in seven patients","volume":"92","author":"Besch","year":"2008","journal-title":"Br. J. Ophthalmol."},{"key":"prgbad811ebib23","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.ajo.2014.02.039","article-title":"The Argus II retinal prosthesis: 12-month outcomes from a single-study center","volume":"157","author":"Rizzo","year":"2014","journal-title":"Am. J. Ophthalmol."},{"key":"prgbad811ebib24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s40942-021-00324-6","article-title":"Argus II retinal prosthesis for retinitis pigmentosa in the Middle East: the 2015 Pan-American Association of Ophthalmology Gradle Lecture","volume":"7","author":"Arevalo","year":"2021","journal-title":"Int. J. Retina Vitreous"},{"key":"prgbad811ebib25","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3928\/23258160-20160324-12","article-title":"Implantation of the Argus II retinal prosthesis in an eye with short axial length","volume":"47","author":"Montezuma","year":"2016","journal-title":"Ophthalmic Surg. Lasers Imaging Retina"},{"key":"prgbad811ebib26","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3928\/23258160-20171215-09","article-title":"Multimodal imaging including optical coherence tomography angiography of a patient with Argus II retinal prosthesis one year after implantation","volume":"49","author":"G\u00fcven","year":"2018","journal-title":"Ophthalmic Surg. Lasers Imaging Retina"},{"key":"prgbad811ebib27","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3928\/23258160-20190129-09","article-title":"Argus II retinal prosthesis implantation in a patient with a history of strabismus surgery: a surgical technique","volume":"50","author":"Narala","year":"2019","journal-title":"Ophthalmic Surg. Lasers Imaging Retina"},{"key":"prgbad811ebib28","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1167\/tvst.8.3.31","article-title":"Histopathologic assessment of optic nerves and retina from a patient with chronically implanted Argus II retinal prosthesis system","volume":"8","author":"Lin","year":"2019","journal-title":"Transl. Vis. Sci. Technol."},{"key":"prgbad811ebib29","first-page":"10","article-title":"The first epiretinal implant for hereditary blindness in the Asia-Pacific region","volume":"80","author":"Yanagihara","year":"2021","journal-title":"Hawaii J. Health Soc. Welfare"},{"key":"prgbad811ebib30","doi-asserted-by":"publisher","first-page":"e595","DOI":"10.1111\/aos.12179","article-title":"A test method for quantification of stimulus-induced depression effects on perceptual threshold in epiretinal prosthesis","volume":"91","author":"Velikay-Parel","year":"2013","journal-title":"Acta Ophthalmol."},{"key":"prgbad811ebib31","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/aos.14443","article-title":"Highest reported visual acuity after electronic retinal implantation","volume":"98","author":"Cehajic Kapetanovic","year":"2020","journal-title":"Acta Ophthalmol."},{"key":"prgbad811ebib32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jcjo.2017.10.043","article-title":"The Toronto experience with the Argus II retinal prosthesis: new technology, new hope for patients","volume":"53","author":"Devenyi","year":"2018","journal-title":"Can. J. Ophthalmol."},{"key":"prgbad811ebib33","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000453606","article-title":"Endoscope-assisted and controlled Argus II epiretinal prosthesis implantation in late-stage retinitis pigmentosa: a report of 2 cases","volume":"7","author":"\u00d6zmert","year":"2016","journal-title":"Case Rep. Ophthalmol."},{"key":"prgbad811ebib34","doi-asserted-by":"publisher","first-page":"e998","DOI":"10.1111\/aos.14435","article-title":"Restriction of eye motility in patients with retina implant Alpha AMS","volume":"98","author":"Faber","year":"2020","journal-title":"Acta Ophthalmol."},{"key":"prgbad811ebib35","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ac9645","article-title":"Long-term observations of macular thickness after subretinal implantation of a photovoltaic prosthesis in patients with atrophic age-related macular degeneration","volume":"19","author":"Muqit","year":"2022","journal-title":"J. Neural Eng."},{"key":"prgbad811ebib36","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1097\/ICB.0000000000000994","article-title":"Intraoperative optical coherence tomography and endoscopy-guided explantation of Argus II device","volume":"16","author":"Cai","year":"2022","journal-title":"Retinal Cases Brief Rep."},{"key":"prgbad811ebib37","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.visres.2015.03.001","article-title":"Subretinal visual implant Alpha IMS\u2013clinical trial interim report","volume":"111","author":"Stingl","year":"2015","journal-title":"Vis. Res."},{"key":"prgbad811ebib38","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1001\/archopht.122.4.460","article-title":"The artificial silicon retina microchip for the treatment of vision loss from retinitis pigmentosa","volume":"122","author":"Chow","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"prgbad811ebib39","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.1167\/iovs.08-2752","article-title":"Implantation and explantation of a wireless epiretinal retina implant device: observations during the EPIRET3 prospective clinical trial","volume":"50","author":"Roessler","year":"2009","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"prgbad811ebib40","doi-asserted-by":"publisher","first-page":"4726","DOI":"10.1167\/iovs.10-6836","article-title":"Testing of semichronically implanted retinal prosthesis by suprachoroidal-transretinal stimulation in patients with retinitis pigmentosa","volume":"52","author":"Fujikado","year":"2011","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"prgbad811ebib41","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.ophtha.2011.09.028","article-title":"Interim results from the international trial of second sight\u2019s visual prosthesis","volume":"119","author":"Humayun","year":"2012","journal-title":"Ophthalmology"},{"key":"prgbad811ebib42","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/eye.2012.35","article-title":"Implantation and explantation of an active epiretinal visual prosthesis: 2-year follow-up data from the EPIRET3 prospective clinical trial","volume":"26","author":"Menzel-Severing","year":"2012","journal-title":"Eye"},{"key":"prgbad811ebib43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115239","article-title":"and bionic vision Australia research consortium. First-in-human trial of a novel suprachoroidal retinal prosthesis","volume":"9","author":"Ayton","year":"2014","journal-title":"PLoS One"},{"key":"prgbad811ebib44","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s00417-014-2797-x","article-title":"Safety evaluation of \u2018retina implant Alpha IMS\u2019\u2013a prospective clinical trial","volume":"253","author":"Kitiratschky","year":"2015","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"prgbad811ebib45","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/j.ophtha.2015.04.032","article-title":"Long-term results from an epiretinal prosthesis to restore sight to the blind","volume":"122","author":"Ho","year":"2015","journal-title":"Ophthalmology"},{"key":"prgbad811ebib46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/842518","article-title":"Extraocular surgical approach for placement of subretinal implants in blind patients: lessons from cochlear-implants","volume":"2015","author":"Koitschev","year":"2015","journal-title":"J. Ophthalmol"},{"key":"prgbad811ebib47","doi-asserted-by":"publisher","first-page":"6147","DOI":"10.1167\/iovs.16-20367","article-title":"One-year outcome of 49-channel suprachoroidal-transretinal stimulation prosthesis in patients with advanced retinitis pigmentosa","volume":"57","author":"Fujikado","year":"2016","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"prgbad811ebib48","doi-asserted-by":"publisher","first-page":"445","DOI":"10.3389\/fnins.2017.00445","article-title":"Interim results of a multicenter trial with the new electronic subretinal implant Alpha AMS in 15 patients blind from inherited retinal degenerations","volume":"11","author":"Stingl","year":"2017","journal-title":"Frontiers Neurosci."},{"key":"prgbad811ebib49","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.ophtha.2017.09.019","article-title":"Assessment of the electronic retinal implant Alpha AMS in restoring vision to blind patients with end-stage retinitis pigmentosa","volume":"125","author":"Edwards","year":"2018","journal-title":"Ophthalmology"},{"key":"prgbad811ebib50","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.ophtha.2018.11.010","article-title":"Six-month safety and efficacy of the intelligent retinal implant system II device in retinitis pigmentosa","volume":"126","author":"Muqit","year":"2019","journal-title":"Ophthalmology"},{"key":"prgbad811ebib51","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1001\/jamaophthalmol.2019.1476","article-title":"One-year safety and performance assessment of the Argus II retinal prosthesis: a postapproval study","volume":"137","author":"Schaffrath","year":"2019","journal-title":"JAMA Ophthalmol."},{"key":"prgbad811ebib52","doi-asserted-by":"publisher","first-page":"52","DOI":"10.24075\/brsmu.2019.042","article-title":"A bionic eye: performance of the Argus II retinal prosthesis in low-vision and social rehabilitation of patients with end-stage retinitis pigmentosa","volume":"3","author":"Takhchidi","year":"2019","journal-title":"Bull. Russ. State Med. Univ."},{"key":"prgbad811ebib53","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.ophtha.2020.02.024","article-title":"Photovoltaic restoration of central vision in atrophic age-related macular degeneration","volume":"127","author":"Palanker","year":"2020","journal-title":"Ophthalmology"},{"key":"prgbad811ebib54","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1167\/tvst.10.10.14","article-title":"First human results with the 256 channel intelligent micro implant eye (IMIE 256)","volume":"10","author":"Xu","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"key":"prgbad811ebib55","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1177\/11206721211000680","article-title":"Electronic retinal prosthesis for severe loss of vision in geographic atrophy in age-related macular degeneration: first-in-human use","volume":"31","author":"Stanga","year":"2021","journal-title":"Eur. J. Ophthalmol."},{"key":"prgbad811ebib56","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1167\/tvst.10.10.12","article-title":"A second-generation (44-channel) suprachoroidal retinal prosthesis: interim clinical trial results","volume":"10","author":"Petoe","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"key":"prgbad811ebib57","doi-asserted-by":"publisher","first-page":"58","DOI":"10.4274\/tjo.galenos.2022.53598","article-title":"Evaluation of the long-term clinical results of 3 patients implanted with the Argus II retinal prosthesis","volume":"53","author":"G\u00fcven","year":"2023","journal-title":"Turk. J. Ophthalmol."},{"key":"prgbad811ebib58","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2019.0051","article-title":"Corneal allograft treatment for conjunctival erosion caused by electronic retinal implant","volume":"138","author":"Rommel","year":"2020","journal-title":"JAMA Ophthalmol."},{"key":"prgbad811ebib59","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1097\/IAE.0000000000002394","article-title":"Adverse events of the Argus II retinal prosthesis: incidence, causes and best practices for managing and preventing conjunctival erosion","volume":"40","author":"Sergio","year":"2020","journal-title":"Retina"},{"key":"prgbad811ebib60","article-title":"Clinical investigation of medical devices for human subjects\u2014good clinical practice","author":"ISO 14155:2020","year":"2020"},{"key":"prgbad811ebib61","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0140-6736(02)07373-7","article-title":"Descriptive studies: what they can and cannot do","volume":"359","author":"Grimes","year":"2002","journal-title":"Lancet"},{"key":"prgbad811ebib62","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1136\/bjophthalmol-2019-314135","article-title":"Hypotony and the Argus II retinal prosthesis: causes, prevention and management","volume":"104","author":"Rizzo","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"prgbad811ebib63","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1001\/jamaophthalmol.2018.6375","article-title":"Assessment of postoperative morphologic retinal changes by optical coherence tomography in recipients of an electronic retinal prosthesis implant","volume":"137","author":"Rizzo","year":"2019","journal-title":"JAMA Ophthalmol."},{"key":"prgbad811ebib64","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1097\/JCMA.0000000000000091","article-title":"First implantation of retinal prosthesis in a patient with high myopia after surgery and rehabilitation program in Taiwan","volume":"82","author":"Hsu","year":"2019","journal-title":"J. Chin. Med. Assoc."},{"key":"prgbad811ebib65","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1097\/IAE.0000000000002780","article-title":"Epiretinal fibrosis removal in an Argus II-implanted eye: histological characteristics and functional results","volume":"40","author":"Patelli","year":"2020","journal-title":"Retina"},{"key":"prgbad811ebib66","doi-asserted-by":"publisher","first-page":"e871","DOI":"10.1111\/aos.14077","article-title":"Changes in microchip position after implantation of a subretinal vision prosthesis in humans","volume":"97","author":"Kuehlewein","year":"2019","journal-title":"Acta Ophthalmol."},{"key":"prgbad811ebib67","doi-asserted-by":"publisher","first-page":"584","DOI":"10.3389\/fnins.2018.00584","article-title":"The Argus-II retinal prosthesis implantation; from the global to local successful experience","volume":"12","author":"Farvardin","year":"2018","journal-title":"Frontiers Neurosci."},{"key":"prgbad811ebib68","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.2147\/OPTH.S96570","article-title":"Argus II retinal prosthesis malrotation and repositioning with intraoperative optical coherence tomography in a posterior staphyloma","volume":"9","author":"Seider","year":"2015","journal-title":"Clin. Ophthalmol."},{"key":"prgbad811ebib69","doi-asserted-by":"publisher","first-page":"462","DOI":"10.3928\/23258160-20190703-10","article-title":"First simultaneous explantation and re-implantation of an Argus II retinal prosthesis system","volume":"50","author":"Seuthe","year":"2019","journal-title":"Ophthalmic Surg. Lasers Imaging Retina"},{"key":"prgbad811ebib70","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.3928\/23258160-20171130-11","article-title":"Positive visual phenomena following implantation of the Argus II retinal prosthesis","volume":"48","author":"Sadaka","year":"2017","journal-title":"Ophthalmic Surg. Lasers Imaging Retina"},{"key":"prgbad811ebib71","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s00417-011-1653-5","article-title":"Angiographic findings following tack fixation of a wireless epiretinal retina implant device in blind RP patients","volume":"249","author":"(The EPIRET Group)","year":"2011","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"prgbad811ebib72","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1056\/NEJMp1406388","article-title":"Sham controls in medical device trials","volume":"371","author":"Redberg","year":"2014","journal-title":"New Engl. J. Med."},{"key":"prgbad811ebib73","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0002-9394(98)00394-8","article-title":"Intermediate-term clinical experience with the Ahmed glaucoma valve implant","volume":"127","author":"Huang","year":"1999","journal-title":"Am. J. Ophthalmol."},{"key":"prgbad811ebib74","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1136\/bjo.2009.165357","article-title":"Ahmed glaucoma valves in refractory glaucoma: a 7-year audit","volume":"94","author":"Wishart","year":"2010","journal-title":"Br. J. Ophthalmol."},{"key":"prgbad811ebib75","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1016\/S0161-6420(98)91049-1","article-title":"A clinical study of the Ahmed glaucoma valve implant in advanced glaucoma","volume":"105","author":"Ayyala","year":"1998","journal-title":"Ophthalmology"},{"key":"prgbad811ebib76","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1097\/IJG.0b013e31826ab693","article-title":"Conjunctival complications related to Ahmed glaucoma valve insertion","volume":"23","author":"Geffen","year":"2014","journal-title":"J. Glaucoma"},{"key":"prgbad811ebib77","first-page":"173","article-title":"Cochlear implants: 1981 to 1985","volume":"6","author":"Berliner","year":"1985","journal-title":"Otol. Neurotol."},{"key":"prgbad811ebib78","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1002\/lary.24649","article-title":"Rates of revision and device failure in cochlear implant surgery: a 30-year experience","volume":"124","author":"Wang","year":"2014","journal-title":"Laryngoscope"},{"key":"prgbad811ebib79","first-page":"pp 427","article-title":"Ophthalmic devices and clinical epidemiology","author":"Eydelman","year":"2007"},{"key":"prgbad811ebib80","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0161-6420(83)34555-3","article-title":"The FDA report on intraocular lenses","volume":"90","author":"Stark","year":"1983","journal-title":"Ophthalmology"},{"key":"prgbad811ebib81","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.cell.2020.04.033","article-title":"Dynamic stimulation of visual cortex produces form vision in sighted and blind humans","volume":"181","author":"Beauchamp","year":"2020","journal-title":"Cell"},{"key":"prgbad811ebib82","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1097\/IAE.0000000000002449","article-title":"Stem cell therapies, gene-based therapies, optogenetics and retinal prosthetics: current state and implications for the future","volume":"39","author":"Wood","year":"2019","journal-title":"Retina"}],"container-title":["Progress in Biomedical Engineering"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2516-1091\/ad811e","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2516-1091\/ad811e\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2516-1091\/ad811e","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2516-1091\/ad811e\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2516-1091\/ad811e\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2516-1091\/ad811e\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2516-1091\/ad811e\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2516-1091\/ad811e\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T09:18:09Z","timestamp":1731316689000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/2516-1091\/ad811e"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":82,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,11,11]]},"published-print":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1088\/2516-1091\/ad811e","relation":{},"ISSN":["2516-1091"],"issn-type":[{"value":"2516-1091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,11]]},"assertion":[{"value":"Harms associated with retinal implantation of a stimulating electrode array to treat outer-retinal degeneration: a systematic review and meta-analysis of safety","name":"article_title","label":"Article Title"},{"value":"Progress in Biomedical Engineering","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2024 The Author(s). Published by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2024-02-12","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-09-27","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-11-11","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}