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Biomed. Eng."],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This review explores the current state of eversion robotics in the context of colonoscopy, given the need for less invasive, more patient-friendly screening technologies. Conventional colonoscopy often leads to discomfort and patient reluctance, contributing to delayed diagnoses and high colorectal cancer mortality rates. Eversion robots, also known as vine robots or soft growing robots are soft, pressure-driven devices that extend by everting from the tip whilst offering a promising option by enabling frictionless advancement and potentially pain-free procedures. We examine the key challenges and opportunities in adapting eversion robots for clinical endoscopic use, focusing on material selection, actuation, steering, and payload delivery. From the literature, thermoplastic polyurethane emerges as the most viable material for the robot\u2019s sleeve due to its airtightness, biocompatibility, suitability for heat or ultrasonic welding, and availability in highly flexible thin layers. Tip-steering mechanisms are identified as the most effective strategies for navigation, allowing high flexibility without increasing the wall thickness of the robot, as required in alternative approaches using distributed actuation mechanisms. The review also evaluates strategies for integrating functional tools at the tip of the robot, concluding that cap-free designs provide superior adaptability to the varying colon diameter, preserve compressibility, and keep tip friction to a minimum, unlike cap-based payload delivery methods. By consolidating current research and identifying pathways for innovation, this review supports the development of eversion soft robots as a next-generation solution for minimally invasive colorectal diagnostics and therapy.<\/jats:p>","DOI":"10.1088\/2516-1091\/ae37b2","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:55:36Z","timestamp":1768344936000},"page":"012012","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["State of the art in soft eversion robots for colonoscopy: a review"],"prefix":"10.1088","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9238-8051","authenticated-orcid":true,"given":"Cem","family":"Suulker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3772-1219","authenticated-orcid":true,"given":"Thomas","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1153-2067","authenticated-orcid":true,"given":"Giovanni","family":"Distefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Ho Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5862-265X","authenticated-orcid":true,"given":"S M Hadi","family":"Sadati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-8313","authenticated-orcid":false,"given":"Laura","family":"Mecozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5330-0053","authenticated-orcid":true,"given":"Shifa","family":"Sulaiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5043-6107","authenticated-orcid":true,"given":"Mohamed","family":"Adhnan Thaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Ficuciello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1037-0588","authenticated-orcid":true,"given":"Bruno","family":"Siciliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Arezzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaspar","family":"Althoefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"prgbae37b2bib1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","type":"journal-article","article-title":"Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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