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Participants identified practical challenges in data access, validation, regulation, and integration into hospital systems, as well as broader socio-economic and trust-related concerns. Opportunities were also recognised for using DTs to influence patient behaviour, enhance preventive care, and support medical education. From these insights, we identified recommendations across six themes: inclusion, clinical relevance, integration and validation, trust and equity, patient involvement, and incentives. The outcomes of this work provide an important step towards improving clinical interest, engagement, and eventual uptake in DTs in healthcare. Incorporating these perspectives into the VHT roadmap has strengthened its alignment with real-world clinical priorities and patient needs, supporting EDITH\u2019s vision of a sustainable and clinically impactful DT ecosystem. Further work is needed to extend this research across a wider range of clinical and patient stakeholder groups, and additional complex, multi-parametric clinical environments such as oncology.<\/jats:p>","DOI":"10.1088\/2516-1091\/aead6b","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:57:18Z","timestamp":1790636238000},"page":"043002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical perspectives on the virtual human twin: an overview of engagement and adoption challenges"],"prefix":"10.1088","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8976-7686","authenticated-orcid":true,"given":"Laura","family":"Bevis","sequence":"first","affiliation":[{"name":"Queen Mary University of London"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Elisa","family":"Rauseo","sequence":"additional","affiliation":[{"name":"Queen Mary University of London"},{"name":"Queen Mary University of London"},{"name":"W. 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