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Struct."],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Electrospun nanofibres based on poly(styrene sulfonate) doped poly(3,4-ethylenedioxythiophene) (PEDOT:PSS) were fabricated using a straightforward procedure which combines electrospinning, sputtering deposition and electrochemical synthesis. In general, electrospun fibre meshes based on conducting polymers are prepared by mixing the conducting polymer with a carrier polymer or chemically coverage of the fibres. In contrast, freestanding nylon 6\/6 nanofibre webs were prepared through electrospinning and were coated by sputtering with gold in order to make them conductive. Further, a PEDOT:PSS layer was electrochemically deposited onto the metalized nanofibre meshes and the synthesis parameters were chosen in such a way to preserve the high active area of the fibres. The prepared material was morphologically characterized and the formation of PEDOT:PSS was also demonstrated. The PEDOT:PSS coated nanofibres revealed remarkable electrical properties (sheet resistance of about 3.5 \u03a9 cm<jats:sup>\u22122<\/jats:sup>), similar to those of metalized nanofibres (sheet resistance around 3 \u03a9 cm2). The <jats:italic>in vitro<\/jats:italic> studies using L929 fibroblast mouse cells showed that the bioactive material has no cytotoxic effect and allows proliferation. Moreover, after 72 h of incubation, the fibroblasts shrunk their nuclei and spread suggesting that a differentiation in myofibroblast occurs without application of any kind of external stimuli. These results will be helpful for developing efficient materials for wound healing applications that work without energy consumption.<\/jats:p>","DOI":"10.1088\/1361-665x\/ad10bf","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T17:24:50Z","timestamp":1701278690000},"page":"015009","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["PEDOT:PSS based electrospun nanofibres used as trigger for fibroblasts differentiation"],"prefix":"10.1088","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-6127","authenticated-orcid":true,"given":"Mihaela","family":"Beregoi","sequence":"first","affiliation":[]},{"given":"Teodor Adrian","family":"Enache","sequence":"additional","affiliation":[]},{"given":"Daniela","family":"Oprea","sequence":"additional","affiliation":[]},{"given":"Monica","family":"Enculescu","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9023-4921","authenticated-orcid":true,"given":"Iulia Corina","family":"Ciobotaru","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Busuioc","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7322-2128","authenticated-orcid":true,"given":"Ionut","family":"Enculescu","sequence":"additional","affiliation":[]}],"member":"266","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"smsad10bfbib1","doi-asserted-by":"publisher","first-page":"3852","DOI":"10.1016\/j.cell.2021.06.024","article-title":"Fibroblasts: origins, definitions, and functions in health and disease","volume":"184","author":"Plikus","year":"2021","journal-title":"Cell"},{"key":"smsad10bfbib2","first-page":"193","author":"Murray","year":"2009","edition":"3rd edn"},{"key":"smsad10bfbib3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1755-1536-6-15","article-title":"Direct isolation of myofibroblasts and fibroblasts from bleomycin-injured lungs reveals their functional similarities and differences","volume":"6","author":"Akamatsu","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"key":"smsad10bfbib4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1159\/000454919","article-title":"Skin wound healing: an update on the current knowledge and concepts","volume":"58","author":"Sorg","year":"2017","journal-title":"Eur. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2023-07-21","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2023-11-29","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2023-12-07","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}