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Neural Eng."],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:italic>Objective<\/jats:italic>. The cochlear implant (CI) belongs to the most successful neuro-prostheses. Traditionally, the stimulating electrode arrays are inserted into the scala tympani (ST), the lower cochlear cavity, which enables simple surgical access. However, often deep insertion is blocked, e.g. by ossification, and the auditory nerve fibers (ANFs) of lower frequency regions cannot be stimulated causing severe restrictions in speech understanding. As an alternative, the CI can be inserted into the scala vestibuli (SV), the other upper cochlear cavity. <jats:italic>Approach<\/jats:italic>. In this computational study, the excitability of 25 ANFs are compared for stimulation with ST and SV implants. We employed a 3-dimensional realistic human cochlear model with lateral wall electrodes based on a <jats:italic>\u03bc<\/jats:italic>-CT dataset and manually traced fibers. A finite element approach in combination with a compartment model of a spiral ganglion cell was used to simulate monophasic stimulation with anodic (ANO) and cathodic (CAT) pulses of 50 <jats:italic>\u03bc<\/jats:italic>s. <jats:italic>Main results<\/jats:italic>. ANO thresholds are lower in ST (mean\/std = <jats:italic>\u03bc<\/jats:italic>\/<jats:italic>\u03c3<\/jats:italic> = 189\/55 <jats:italic>\u03bc<\/jats:italic>A) stimulation compared to SV (<jats:italic>\u03bc<\/jats:italic>\/<jats:italic>\u03c3<\/jats:italic> = 323\/119 <jats:italic>\u03bc<\/jats:italic>A) stimulation. Contrary, CAT thresholds are higher for the ST array (<jats:italic>\u03bc<\/jats:italic>\/<jats:italic>\u03c3<\/jats:italic> = 165\/42 <jats:italic>\u03bc<\/jats:italic>A) compared to the SV array (<jats:italic>\u03bc<\/jats:italic>\/<jats:italic>\u03c3<\/jats:italic> = 122\/46 <jats:italic>\u03bc<\/jats:italic>A). The threshold amplitude depends on the specific fiber-electrode spatial relationship, such as lateral distance from the cochlear axis, the angle between electrode and target ANF, and the curvature of the peripheral process. For CAT stimulation the SV electrodes show a higher selectivity leading to less cross-stimulation of additional fibers from different cochlear areas. <jats:italic>Significance<\/jats:italic>. We present a first simulation study with a human cochlear model that investigates an additional CI placement into the SV and its impact on the excitation behavior. Results predict comparable outcomes to ST electrodes which confirms that SV implantation might be an alternative for patients with a highly obstructed ST.<\/jats:p>","DOI":"10.1088\/1741-2552\/ad6597","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:05:44Z","timestamp":1721433944000},"page":"046034","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Auditory nerve fiber excitability for alternative electrode placement in the obstructed human cochlea: electrode insertion in scala vestibuli versus scala tympani"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3704-8764","authenticated-orcid":true,"given":"Andreas","family":"Fellner","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-9093","authenticated-orcid":false,"given":"Cornelia","family":"Wenger","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2052-152X","authenticated-orcid":true,"given":"Amirreza","family":"Heshmat","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2819-8827","authenticated-orcid":true,"given":"Frank","family":"Rattay","sequence":"additional","affiliation":[]}],"member":"266","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"jnead6597bib1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1113\/jphysiol.1980.sp013465","article-title":"Ultrastructural dimensions of myelinated peripheral nerve fibres in the cat and their relation to conduction velocity","volume":"308","author":"Arbuthnott","year":"1980","journal-title":"J. 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