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Neural Eng."],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective.<\/jats:italic>\n                    Computational modeling has recently emerged as a powerful tool to better understand seizure dynamics and guide new treatment strategies. This work aims to develop and personalize whole-brain computational models in epilepsy using multimodal clinical data to simulate and evaluate individualized therapeutic strategies.\n                    <jats:italic>Approach.<\/jats:italic>\n                    We present a computational framework that constructs patient-specific whole-brain models of seizure propagation by integrating SEEG, MRI, and diffusion MRI data. The pipeline uses neural mass models for each node in the network, simulating whole-brain dynamics. Model personalization involves adjusting global and local parameters representing the excitability of individual brain areas, using an evolutionary algorithm that aims to maximize the correlation between empirical and synthetic functional connectivity matrices derived from SEEG data.\n                    <jats:italic>Main results.<\/jats:italic>\n                    The resulting personalized models successfully reproduce individual seizure propagation patterns and can be used to simulate therapeutic interventions like surgery, stimulation, or pharmacological interventions within a unified physiological framework. Notably, model predictions reveal distinct patient-specific responses across interventions, including variable sensitivity to different pharmacological agents and identification of critical regions whose removal or modulation reduced seizure spread.\n                    <jats:italic>Significance.<\/jats:italic>\n                    This framework provides a mechanistic, interpretable approach to simulate and compare individualized treatment strategies. By integrating multimodal data into a unified whole-brain model, it has the potential to improve clinical decision-making in epilepsy by identifying accessible and functionally relevant targets.\n                  <\/jats:p>","DOI":"10.1088\/1741-2552\/ae08e9","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T22:51:48Z","timestamp":1758235908000},"page":"056019","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Personalized whole-brain models of seizure propagation"],"prefix":"10.1088","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9062-4428","authenticated-orcid":true,"given":"Edmundo","family":"Lopez-Sola","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0941-6796","authenticated-orcid":true,"given":"Borja","family":"Mercadal","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0106-6266","authenticated-orcid":true,"given":"\u00c8lia","family":"Lleal-Custey","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1235-6533","authenticated-orcid":true,"given":"Ricardo","family":"Salvador","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1580-8750","authenticated-orcid":false,"given":"Roser","family":"Sanchez-Todo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2428-9665","authenticated-orcid":false,"given":"Fabrice","family":"Wendling","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-0297","authenticated-orcid":false,"given":"Fabrice","family":"Bartolomei","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3084-0177","authenticated-orcid":true,"given":"Giulio","family":"Ruffini","sequence":"additional","affiliation":[]}],"member":"266","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"jneae08e9bib1","article-title":"Epilepsy: a public health imperative","author":"World Health Organization","year":"2019","type":"other"},{"key":"jneae08e9bib2","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1056\/NEJM200002033420503","type":"journal-article","article-title":"Early identification of refractory epilepsy","volume":"342","author":"Kwan","year":"2000","journal-title":"New Engl. 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