{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:36:13Z","timestamp":1768574173044,"version":"3.49.0"},"reference-count":60,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A calcium phosphate (CaP)-based scaffold used as synthetic bone grafts, which smartly combines precise dimensions, controlled porosity and therapeutic functions, presents benefits beyond those offered by conventional practices, although its fabrication is still a challenge. The sintering step normally required to improve the strength of the ceramic scaffolds precludes the addition of any biomolecules or functional particles before this stage.<\/jats:p>\n                  <jats:p>This study presents a proof of concept of multifunctional CaP-based scaffolds, fabricated by additive manufacturing from an innovative ink composition, with potential for bone regeneration, cancer treatment by local magnetic hyperthermia and drug delivery platforms. Highly loaded inks comprising iron-doped hydroxyapatite and \u03b2-tricalcium phosphate powders suspended in a chitosan-based solution, in the presence of levofloxacin (LEV) as model drug and magnetic nanoparticles (MNP), were developed. The sintering step was removed from the production process, and the integrity of the printed scaffolds was assured by the polymerization capacity of the ink composite, using genipin as a crosslinking agent. The effects of MNP and LEV on the inks\u2019 rheological properties, as well as on the mechanical and structural behaviour of non-doped and iron-doped scaffolds, were evaluated. Magnetic and magneto-thermal response, drug delivery and biological performance, such as cell proliferation in the absence and presence of an applied magnetic field, were also assessed. The addition of a constant amount of MNP in the iron-doped and non-doped CaP-based inks enhances their magnetic response and induction heating, with these effects more pronounced for the iron-doped CaP-based ink. These results suggest a synergistic effect between the iron-doped CaP-based powders and the MNP due to ferro\/ferrimagnetic interactions. Furthermore, the iron presence enhances human mesenchymal stem cell metabolic activity and proliferation.<\/jats:p>","DOI":"10.1088\/1748-605x\/abac4c","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T18:32:10Z","timestamp":1596565930000},"page":"015011","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Effective production of multifunctional magnetic-sensitive biomaterial by an extrusion-based additive manufacturing technique"],"prefix":"10.1088","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5521-3992","authenticated-orcid":false,"given":"A F M","family":"Rodrigues","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7136-984X","authenticated-orcid":false,"given":"P M C","family":"Torres","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-2490","authenticated-orcid":false,"given":"M J S","family":"Barros","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4079-7291","authenticated-orcid":false,"given":"R","family":"Presa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9975-5432","authenticated-orcid":false,"given":"N","family":"Ribeiro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4595-3641","authenticated-orcid":false,"given":"J C C","family":"Abrantes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-1568","authenticated-orcid":false,"given":"J H","family":"Belo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0488-9372","authenticated-orcid":false,"given":"J S","family":"Amaral","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3359-7133","authenticated-orcid":false,"given":"V S","family":"Amaral","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4319-2631","authenticated-orcid":false,"given":"M","family":"Ba\u00f1obre-L\u00f3pez","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8498-5892","authenticated-orcid":false,"given":"A","family":"Bettencourt","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2191-8892","authenticated-orcid":false,"given":"A","family":"Sousa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1269-8683","authenticated-orcid":false,"given":"S M","family":"Olhero","sequence":"additional","affiliation":[]}],"member":"266","published-online":{"date-parts":[[2020,12,11]]},"reference":[{"key":"bmmabac4cbib1","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.tibtech.2015.06.006","type":"journal-article","article-title":"Harnessing magnetic-mechano actuation in regenerative medicine and tissue engineering","volume":"33","author":"Santos","year":"2015","journal-title":"Trends Biotechnol."},{"key":"bmmabac4cbib2","doi-asserted-by":"publisher","first-page":"360","DOI":"10.2174\/0929866523666160720094638","type":"journal-article","article-title":"Developing antitumor magnetic hyperthermia: principles, materials and devices","volume":"11","author":"Tishin","year":"2016","journal-title":"Recent Pat. Anti-Cancer Drug Discovery"},{"key":"bmmabac4cbib3","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S1507-1367(10)60065-X","type":"journal-article","article-title":"Hyperthermia \u2013 description of a method and a review of clinical applications","volume":"12","author":"Chiche\u0142","year":"2007","journal-title":"Rep. Pract. Oncol. Radiother."},{"key":"bmmabac4cbib4","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1080\/02656730902835664","type":"journal-article","article-title":"Combination of hyperthermia and bortezomib results in additive killing in mantle cell lymphoma cells","volume":"25","author":"Milani","year":"2009","journal-title":"Int. J. Hyperthermia"},{"key":"bmmabac4cbib5","doi-asserted-by":"publisher","first-page":"228","DOI":"10.11138\/jts\/2016.4.4.228","type":"journal-article","article-title":"The prospective opportunities offered by magnetic scaffolds for bone tissue engineering: a review","volume":"4","author":"Ortolani","year":"2016","journal-title":"Joints"},{"key":"bmmabac4cbib6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.actbio.2017.03.030","type":"journal-article","article-title":"3D printing for the design and fabrication of polymer-based gradient scaffolds","volume":"56","author":"Bracaglia","year":"2017","journal-title":"Acta Biomater."},{"key":"bmmabac4cbib7","doi-asserted-by":"publisher","first-page":"6905","DOI":"10.1021\/acsami.6b00815","type":"journal-article","article-title":"Low-temperature additive manufacturing of biomimic three-dimensional hydroxyapatite\/collagen scaffolds for bone regeneration","volume":"8","author":"Lin","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bmmabac4cbib8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mattod.2015.10.008","type":"journal-article","article-title":"Calcium phosphates in biomedical applications: materials for the future?","volume":"19","author":"Habraken","year":"2016","journal-title":"Mater. Today"},{"key":"bmmabac4cbib9","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/adhm.201300562","type":"journal-article","article-title":"Biopolymer\/calcium phosphate scaffolds for bone tissue engineering","volume":"3","author":"Li","year":"2013","journal-title":"Adv. Healthcare Mater."},{"key":"bmmabac4cbib10","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.actbio.2014.12.021","type":"journal-article","article-title":"Fabrication of novel Si-doped hydroxyapatite\/gelatine scaffolds by rapid prototyping for drug delivery and bone regeneration","volume":"15","author":"Mart\u00ednez-V\u00e1zquez","year":"2015","journal-title":"Acta Biomater."},{"key":"bmmabac4cbib11","doi-asserted-by":"publisher","first-page":"4377","DOI":"10.1039\/C5TB00062A","type":"journal-article","article-title":"Biocompatibility and osteogenic capacity of borosilicate bioactive glass scaffolds loaded with Fe3O4 magnetic nanoparticles","volume":"3","author":"Wang","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"bmmabac4cbib12","doi-asserted-by":"publisher","first-page":"495","DOI":"10.3390\/ijms19020495","type":"journal-article","article-title":"3D biomimetic magnetic structures for static magnetic field stimulation of osteogenesis","volume":"19","author":"Paun","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"bmmabac4cbib13","doi-asserted-by":"publisher","first-page":"541","DOI":"10.3390\/nano9040541","type":"journal-article","article-title":"Magnetic dehydrodipeptide-based self-assembled hydrogels for theragnostic applications","volume":"9","author":"Carvalho","year":"2019","journal-title":"Nanomaterials"},{"key":"bmmabac4cbib14","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1093\/rb\/rbw039","type":"journal-article","article-title":"A magnetic hydroxyapatite composite scaffold-based magnetic therapy for bone repair: an experimental study in canis lupus familiaris","volume":"4","author":"He","year":"2017","journal-title":"Regener. Biomater."},{"key":"bmmabac4cbib15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1109\/TMAG.2014.2327245","type":"journal-article","article-title":"Hyperthermia induced in magnetic scaffolds for bone tissue engineering","volume":"50","author":"Ba\u00f1obre-L\u00f3pez","year":"2014","journal-title":"IEEE Trans. Magn."},{"key":"bmmabac4cbib16","doi-asserted-by":"publisher","first-page":"2874","DOI":"10.1039\/C6TB00390G","type":"journal-article","article-title":"3D-printed bioceramic scaffolds with a Fe3O4\/graphene oxide nanocomposite interface for hyperthermia therapy of bone tumor cells","volume":"4","author":"Zhang","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"bmmabac4cbib17","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1002\/adfm.201504142","type":"journal-article","article-title":"A bifunctional biomaterial with photothermal effect for tumor therapy and bone regeneration","volume":"26","author":"Ma","year":"2016","journal-title":"Adv. Funct. Mater."},{"key":"bmmabac4cbib18","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.matdes.2017.03.036","type":"journal-article","article-title":"Review on magnetic nanoparticles for magnetic nanofluid hyperthermia application","volume":"123","author":"Hedayatnasab","year":"2017","journal-title":"Mater. Des."},{"key":"bmmabac4cbib19","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.pnsc.2016.09.004","type":"journal-article","article-title":"Structural effects on the magnetic hyperthermia properties of iron oxide","volume":"26","author":"Abenojar","year":"2016","journal-title":"Prog. Nat. Sci."},{"key":"bmmabac4cbib20","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.bbamcr.2016.12.002","type":"journal-article","article-title":"Iron mediated toxicity and programmed cell death: a review and a re-examination of existing paradigms","volume":"1864","author":"Eid","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"bmmabac4cbib21","doi-asserted-by":"publisher","first-page":"815","DOI":"10.2217\/nnm.11.79","type":"journal-article","article-title":"In vivo biodistribution of nanoparticles","volume":"6","author":"Almeida","year":"2011","journal-title":"Nanomedicine"},{"key":"bmmabac4cbib22","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.actbio.2011.11.017","type":"journal-article","article-title":"Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review","volume":"8","author":"Bose","year":"2012","journal-title":"Acta Biomater."},{"key":"bmmabac4cbib23","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.msec.2017.04.130","type":"journal-article","article-title":"Iron doped \u03b2-Tricalcium phosphate: synthesis, characterization, hyperthermia effect, biocompatibility and mechanical evaluation","volume":"78","author":"Sam","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"bmmabac4cbib24","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.actbio.2011.09.032","type":"journal-article","article-title":"Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite","volume":"8","author":"Tampieri","year":"2012","journal-title":"Acta Biomater."},{"key":"bmmabac4cbib25","doi-asserted-by":"publisher","first-page":"15697","DOI":"10.1021\/am5050967","type":"journal-article","article-title":"Magnetic bioinspired hybrid nanostructured collagen\u2212hydroxyapatite scaffolds supporting cell proliferation and tuning regenerative process","volume":"6","author":"Tampieri","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bmmabac4cbib26","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.msec.2018.09.050","type":"journal-article","article-title":"Novel sintering-free scaffolds obtained by additive manufacturing for concurrent bone regeneration and drug delivery: proof of concept","volume":"94","author":"Marques","year":"2019","journal-title":"Mater. Sci. Eng."},{"key":"bmmabac4cbib27","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.actbio.2016.12.011","type":"journal-article","article-title":"Atomic scale modeling of iron-doped biphasic calcium phosphate bioceramics","volume":"50","author":"Gomes","year":"2017","journal-title":"Acta Biomater."},{"key":"bmmabac4cbib28","doi-asserted-by":"publisher","first-page":"5719","DOI":"10.1016\/j.ceramint.2017.08.133","type":"journal-article","article-title":"Biocompatibility and antimicrobial activity of biphasic calcium phosphate powders doped with metal ions for regenerative medicine","volume":"43","author":"Marques","year":"2017","journal-title":"Ceram. Int."},{"key":"bmmabac4cbib29","doi-asserted-by":"publisher","first-page":"7314","DOI":"10.3390\/md13127068","type":"journal-article","article-title":"Genipin-crosslinked chitosan gels and scaffolds for tissue engineering and regeneration of cartilage and bone","volume":"13","author":"Muzzarelli","year":"2015","journal-title":"Mar. Drugs"},{"key":"bmmabac4cbib30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-40201-9","type":"journal-article","article-title":"The degradation of levofloxacin in infusions exposed to daylight with an identification of a degradation product with HPLC-MS","volume":"9","author":"Czyrski","year":"2019","journal-title":"Sci. Rep."},{"key":"bmmabac4cbib31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceramint.2014.02.009","type":"journal-article","article-title":"Dielectric properties of Fe doped hydroxyapatite prepared by sol-gel method","volume":"40","author":"Kaygili","year":"2014","journal-title":"Ceram. Int."},{"key":"bmmabac4cbib32","doi-asserted-by":"publisher","first-page":"11774","DOI":"10.1021\/ic801491t","type":"journal-article","article-title":"The crystal chemistry of ferric oxyhydroxyapatite","volume":"47","author":"Low","year":"2008","journal-title":"J. Inorg. Chem."},{"key":"bmmabac4cbib33","doi-asserted-by":"publisher","first-page":"6017","DOI":"10.1038\/s41598-017-06115-0","type":"journal-article","article-title":"Linking rheology and printability for dense and strong ceramics by direct ink writing","volume":"7","author":"Barki","year":"2017","journal-title":"Sci. Rep."},{"key":"bmmabac4cbib34","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.jeurceramsoc.2016.08.018","type":"journal-article","article-title":"Biphasic calcium phosphate scaffolds fabricated by direct write assembly: mechanical, anti-microbial and osteoblastic properties","volume":"37","author":"Marques","year":"2016","journal-title":"J. Eur. Ceram. Soc."},{"key":"bmmabac4cbib35","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.jcf.2006.01.003","type":"journal-article","article-title":"Altered steady state pharmacokinetics of levofloxacin in adult cystic fibrosis patients receiving calcium carbonate","volume":"5","author":"Pai","year":"2006","journal-title":"J. Cystic. Fibrosis"},{"key":"bmmabac4cbib36","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1111\/jace.13700","type":"journal-article","article-title":"Additive manufacturing of ceramics: issues, potentialities, and opportunities","volume":"98","author":"Zocca","year":"2015","journal-title":"J. Am. Ceram. Soc."},{"key":"bmmabac4cbib37","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S0955-2219(99)00182-X","type":"journal-article","article-title":"Synergy of polysaccharide mixtures in gelcasting of alumina J","volume":"20","author":"Olhero","year":"2000","journal-title":"Eur. Ceram. Soc."},{"key":"bmmabac4cbib38","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/B978-0-12-405545-2.00001-1","type":"book","author":"Reis","year":"2013"},{"key":"bmmabac4cbib39","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1021\/cm300301c","type":"journal-article","article-title":"Superparamagnetic MFe2O4 (M = Fe, Co, Mn) nanoparticles: tuning the particle size and magnetic properties through a novel one-step coprecipitation route","volume":"24","author":"Pereira","year":"2012","journal-title":"Chem. Mater."},{"key":"bmmabac4cbib40","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/3527602097.ch6","type":"book","author":"Cornell","year":"2003","edition":"2nd"},{"key":"bmmabac4cbib41","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1021\/la3037007","type":"journal-article","article-title":"Superparamagnetic iron oxide nanoparticles with variable size and an iron oxidation state as prospective imaging agents","volume":"29","author":"Kucheryavy","year":"2013","journal-title":"Langmuir"},{"key":"bmmabac4cbib42","doi-asserted-by":"publisher","first-page":"17380","DOI":"10.3390\/ijms151017380","type":"journal-article","article-title":"Hyperthermia induces apoptosis through endoplasmic reticulum and reactive oxygen species in human osteosarcoma cells","volume":"15","author":"Hou","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"bmmabac4cbib43","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.rpor.2013.09.011","type":"journal-article","article-title":"Magnetic nanoparticle-based hyperthermia for cancer treatment","volume":"18","author":"Ba\u00f1obre-L\u00f3pez","year":"2013","journal-title":"Rep. Pract. Oncol. Radiother."},{"key":"bmmabac4cbib44","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1080\/08927014.2013.834893","type":"journal-article","article-title":"Effect of magnetic hyperthermia on the structure of biofilm and cellular viability of a food spoilage bacterium","volume":"29","author":"Rodrigues","year":"2013","journal-title":"Biofouling"},{"key":"bmmabac4cbib45","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.bioactmat.2017.04.003","type":"journal-article","article-title":"3D additive-manufactured nanocomposite magnetic scaffolds: effect of the application mode of a time-dependent magnetic field on hMSCs behavior","volume":"2","author":"Amora","year":"2017","journal-title":"Bioact. Mater."},{"key":"bmmabac4cbib46","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1016\/j.biomaterials.2005.08.035","type":"journal-article","article-title":"A comparison of micro CT with other techniques used in the characterization of scaffolds","volume":"27","author":"Tuan Ho","year":"2006","journal-title":"Biomaterials"},{"key":"bmmabac4cbib47","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.actbio.2010.07.012","type":"journal-article","article-title":"A review of the mechanical behavior of CaP and CaP\/polymer composites for applications in bone replacement and repair","volume":"7","author":"Johnson","year":"2011","journal-title":"Acta Biomater."},{"key":"bmmabac4cbib48","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jconrel.2015.08.049","type":"journal-article","article-title":"Controlled drug release for tissue engineering","volume":"219","author":"Rambhia","year":"2015","journal-title":"J. Controlled Release"},{"key":"bmmabac4cbib49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/adhm.201801512","type":"journal-article","article-title":"3D plotted biphasic bone scaffolds for growth factor delivery: biological characterization in vitro and in vivo","volume":"8","author":"Ahlfeld","year":"2019","journal-title":"Adv. Healthcare Mater."},{"key":"bmmabac4cbib50","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jconrel.2008.05.020","type":"journal-article","article-title":"Antibiotic-eluting medical devices for various applications","volume":"130","author":"Zilberman","year":"2008","journal-title":"J. Controlled Release"},{"key":"bmmabac4cbib51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/ten.2005.11.1","type":"journal-article","article-title":"Mediation of biomaterial\u2013cell interactions by adsorbed proteins: a review","volume":"11","author":"Wilson","year":"2005","journal-title":"Tissue Eng."},{"key":"bmmabac4cbib52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40824-018-0149-3","type":"journal-article","article-title":"Bioactive calcium phosphate materials and applications in bone regeneration","volume":"23","author":"Jeong","year":"2019","journal-title":"Biomater. Res."},{"key":"bmmabac4cbib53","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.4103\/0366-6999.155121","type":"journal-article","article-title":"Calcium phosphate scaffolds combined with bone morphogenetic proteins or mesenchymal stem cells in bone tissue engineering","volume":"128","author":"Sun","year":"2015","journal-title":"Chin. Med. J. (Engl)."},{"key":"bmmabac4cbib54","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s10616-015-9895-4","type":"journal-article","article-title":"Scaffolds and cells for tissue regeneration: different scaffold pore sizes\u2014different cell effects","volume":"68","author":"Bru\u017eauskait\u0117","year":"2016","journal-title":"Cytotechnology"},{"key":"bmmabac4cbib55","first-page":"164","type":"journal-article","article-title":"Review on iron and its importance for human health","volume":"19","author":"Abbaspour","year":"2014","journal-title":"J. Res. Med. Sci."},{"key":"bmmabac4cbib56","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0005-2728(99)00088-2","type":"journal-article","article-title":"Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation","volume":"1413","author":"Oexle","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"bmmabac4cbib57","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1093\/rb\/rby001","type":"journal-article","article-title":"Effect of microporosity on scaffolds for bone tissue engineering","volume":"5","author":"Zhang","year":"2018","journal-title":"Regener. Biomater."},{"key":"bmmabac4cbib58","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1023\/B:JMSM.0000004006.90399.b4","type":"journal-article","article-title":"Effect of micro and macroporosity of bone substitutes on their mechanical properties and cellular response","volume":"14","author":"Bignon","year":"2003","journal-title":"J. Mater. Sci."},{"key":"bmmabac4cbib59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0038710","type":"journal-article","article-title":"Magnetic hydroxyapatite bone substitutes to enhance tissue regeneration: evaluation in vitro using osteoblast-like cells and in vivo in a bone defect","volume":"7","author":"Panseri","year":"2012","journal-title":"Plos One"},{"key":"bmmabac4cbib60","doi-asserted-by":"publisher","first-page":"263","DOI":"10.5923\/j.ajbe.20120206.05","type":"journal-article","article-title":"Evaluation of the effects of a moderate intensity static magnetic field application on human osteoblast-like cells","volume":"2","author":"Cunha","year":"2012","journal-title":"Am. J. Biomed. Eng."}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/abac4c","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/abac4c\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/abac4c","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/abac4c\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/abac4c\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/abac4c","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/abac4c\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/abac4c\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/abac4c\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/abac4c\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/abac4c\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/abac4c","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T13:22:27Z","timestamp":1765027347000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/abac4c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,11]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12,11]]},"published-print":{"date-parts":[[2021,1,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/abac4c","relation":{},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"value":"1748-6041","type":"print"},{"value":"1748-605X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,11]]},"assertion":[{"value":"Effective production of multifunctional magnetic-sensitive biomaterial by an extrusion-based additive manufacturing technique","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2020 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-04-27","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-08-04","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-12-11","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}