{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T13:26:32Z","timestamp":1763817992231,"version":"3.45.0"},"reference-count":44,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["SFRH\/BD\/71113\/2010"],"award-info":[{"award-number":["SFRH\/BD\/71113\/2010"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Additive Manufacturing (AM) technologies are an effective route to fabricate tailor made scaffolds for tissue engineering (TE) and regenerative medicine, with microstereo-lithography (\u00b5SLA) being one of the most promising techniques to produce high quality 3D structures. Here, we report the crosslinking studies of fully biobased unsaturated polyesters (UPs) with 2-hydroxyethyl methacrylate (HEMA) as the unsaturated monomer (UM), using thermal and \u00b5SLA crosslinking processes. The resulting resins were fully characterized in terms of their thermal and mechanical properties. Determination of gel content, water contact angle, topography and morphology analysis by atomic force microscopy and scanning electron microscopy were also performed. The results show that the developed UP resins (UPRs) have promising properties for \u00b5SLA.\n                    <jats:italic>In vitro<\/jats:italic>\n                    cytotoxicity assays performed with 3T3-L1 cell lines showed that the untreated scaffolds exhibited a maximum cellular viability around 60%, which was attributed to the acidic nature of the UPRs. The treatment of the UPRs and scaffolds with ethanol (EtOH) improved the cellular viability to 100%. The data presented in this manuscript contribute to improve the performance of biobased UPs in AM.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ac4b46","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T17:47:07Z","timestamp":1642096027000},"page":"025010","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Fabrication of 3D scaffolds based on fully biobased unsaturated polyester resins by microstereo-lithography"],"prefix":"10.1088","volume":"17","author":[{"given":"Filipa A M M","family":"Gon\u00e7alves","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7145-2472","authenticated-orcid":true,"given":"Ana C","family":"Fonseca","sequence":"additional","affiliation":[]},{"given":"Rosemeyre","family":"Cordeiro","sequence":"additional","affiliation":[]},{"given":"Ana P","family":"Piedade","sequence":"additional","affiliation":[]},{"given":"Henrique","family":"Faneca","sequence":"additional","affiliation":[]},{"given":"Arm\u00e9nio","family":"Serra","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9351-1704","authenticated-orcid":true,"given":"Jorge F J","family":"Coelho","sequence":"additional","affiliation":[]}],"member":"266","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"bmmac4b46bib1","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.progpolymsci.2011.11.007","type":"journal-article","article-title":"Additive manufacturing of tissues and organs","volume":"37","author":"Melchels","year":"2012","journal-title":"Prog. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2021-08-06","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2022-01-13","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2022-02-03","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}