{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:53:48Z","timestamp":1778511228505,"version":"3.51.4"},"reference-count":30,"publisher":"IOP Publishing","issue":"3","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Portuguese Platform of BioImaging","award":["POCI-01-0145-FEDER-022122"],"award-info":[{"award-number":["POCI-01-0145-FEDER-022122"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/BTM-MAT\/31498\/2017"],"award-info":[{"award-number":["PTDC\/BTM-MAT\/31498\/2017"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biofabrication"],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Embedded bio-printing has fostered significant advances toward the fabrication of soft complex tissue-like constructs, by providing a physical support that allows the freeform shape maintenance within the prescribed spatial arrangement, even under gravity force. Current supporting materials still present major drawbacks for up-scaling embedded 3D bio-printing technology towards tissue-like constructs with clinically relevant dimensions. Herein, we report a a cost-effective and widely available supporting material for embedded bio-printing consisting on a continuous pseudo-plastic matrix of xanthan-gum (XG). This natural polisaccharide exhibits peculiar rheological properties that have enabled the rapid generation of complex volumetric 3D constructs with out-of-plane features. The freedom of design within the three orthogonal axes through the independent and controlled bio-printing process opens new opportunities to produce on demand large arbitrary shapes for personalized medicine. Additionally, we have demonstrated the versatile functionality of XG as a photocurable gel reservoir to engineer perfused cell-laden hydrogel constructs, addressing other practical biomedical applications such as\n                    <jats:italic>in vitro<\/jats:italic>\n                    models and organ-on-chip platforms.\n                  <\/jats:p>","DOI":"10.1088\/1758-5090\/ab8bc3","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T18:45:11Z","timestamp":1587494711000},"page":"035017","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":85,"title":["Freeform 3D printing using a continuous viscoelastic supporting matrix"],"prefix":"10.1088","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4976-7662","authenticated-orcid":false,"given":"S\u00f3nia G","family":"Patr\u00edcio","sequence":"first","affiliation":[]},{"given":"Liliana R","family":"Sousa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-4698","authenticated-orcid":false,"given":"Tiago R","family":"Correia","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0372-2493","authenticated-orcid":false,"given":"V\u00edtor M","family":"Gaspar","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9054-468X","authenticated-orcid":false,"given":"Liliana S","family":"Pires","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8846-439X","authenticated-orcid":false,"given":"Jorge L","family":"Lu\u00eds","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-5728","authenticated-orcid":false,"given":"Jos\u00e9 M","family":"Oliveira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-3765","authenticated-orcid":false,"given":"Jo\u00e3o F","family":"Mano","sequence":"additional","affiliation":[]}],"member":"266","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"key":"bfab8bc3bib1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2019.100589","type":"journal-article","article-title":"Modular fabrication of intelligent material-tissue interfaces for bioinspired and biomimetic devices","volume":"106","author":"Clegg","year":"2019","journal-title":"Prog. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-01-17","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-04-21","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-05-13","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}