{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:06:55Z","timestamp":1792001215803,"version":"4.4.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2001,12]]},"abstract":"\n A susceptibility surveillance study of 1,274 bacterial isolates recovered from various clinical specimens from patients in intensive care units (ICUs) of five major teaching hospitals was carried out from\n March, 2000, to June, 2000, in Taiwan. This study demonstrated a high rate (66%) of oxacillin resistance in\n Staphylococcus aureus<\/jats:italic>\n (ORSA), a high rate of nonsusceptibility to penicillin (intermediate,\n 50% and highly resistant, 8%), and high rates of cefotaxime nonsusceptibility for\n S. pneumoniae<\/jats:italic>\n (intermediate, 29% and resistant, 4%),\n Enterobacter cloacae<\/jats:italic>\n (57%),\n Serratia marcescens<\/jats:italic>\n (34%), and\n Citrobacter freundii<\/jats:italic>\n (60%). High rate of ceftazidime nonsusceptibility for\n Pseudomonas aeruginosa<\/jats:italic>\n (22%), and high rates of imipenem nonsusceptibility for\n P. aeruginosa<\/jats:italic>\n (15%)\n and\n Acinetobacter baumannii<\/jats:italic>\n (22%) were also found. The percentage (11.9%) of extended-spectrum\n \u03b2<\/jats:italic>\n -lactamase (ESBL)-producing\n Escherichia coli<\/jats:italic>\n was greater than that (11.3%) for\n Klebsiella\n pneumoniae<\/jats:italic>\n . Rates of quinupristin-dalfopristin nonsusceptibility for\n S. pneumoniae<\/jats:italic>\n (42%),\n Enterococcus faecium<\/jats:italic>\n (71%), and ORSA (39%) were high, but no vancomycin-resistant enterococci\n were found in this study. The resistance rates of some pathogen varied by institution or type of ICUs. Surveillance for antimicrobial resistance among bacterial pathogens in hospitals, particularly in ICU\n settings with a preexisting higher resistance burden, is mandatory in establishing and\/or modifying guidelines for empirical treatment of severe infections in ICU patients caused by these antimicrobial-resistant\n pathogens.\n <\/jats:p>","DOI":"10.1089\/10766290152773383","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:08:35Z","timestamp":1027706915000},"page":"373-382","source":"Crossref","is-referenced-by-count":55,"title":["Multicenter Surveillance of Antimicrobial Resistance of Major Bacterial Pathogens in Intensive Care Units in 2000 in Taiwan"],"prefix":"10.1177","volume":"7","author":[{"given":"Po-Ren","family":"Hsueh","sequence":"first","affiliation":[{"name":"Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Ching","family":"Liu","sequence":"additional","affiliation":[{"name":"Departments of Clinical Pathology and Internal Medicine, Veterans General Hospital-Kaohsiung, and National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dine","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Mackay Memorial Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jou","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, National Cheng-Kung University Hospital, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsu-Lan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Chang Gung Memorial Hospital, Lin-Kou, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Kuei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Veterans General Hospital-Kaohsiung, and National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn-Jong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, National Cheng-Kung University Hospital, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chien","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Cheng-Kung University Hospital, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsieh-Shong","family":"Leu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chang Gung Memorial Hospital, Lin-Kou, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong-Ren","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwen-Tay","family":"Luh","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2001,12]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/10766290152773383","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/10766290152773383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:13:58Z","timestamp":1770747238000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/10766290152773383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1089\/10766290152773383"],"URL":"https:\/\/doi.org\/10.1089\/10766290152773383","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}