{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T22:42:06Z","timestamp":1770763326959,"version":"3.50.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p>\n                    The objective of the study was to investigate antimicrobial resistance, plasmids and class 1 integrons in 150\n                    <jats:italic toggle=\"yes\">Shigella<\/jats:italic>\n                    strains isolated from patients with diarrhea in Vietnam. Most isolates were\n         resistant to the majority of antimicrobial agents used for treatment in the isolation areas and 90% were resistant to three or more antibiotics. A total of 20 strains yielded class 1 integrons, which harbored\n                    <jats:italic toggle=\"yes\">oxa1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">dfrA<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">orfF<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">aadA<\/jats:italic>\n                    gene cassettes. The most common gene cassette,\n                    <jats:italic toggle=\"yes\">aadA2<\/jats:italic>\n                    , was always located closest to the 3\u2032 conserved segment of the integrons and\n                    <jats:italic toggle=\"yes\">oxa1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">dfrA<\/jats:italic>\n                    closest to the 5\u2032 end. Plasmid profiles of the 20 class 1 integron-positive strains all contained more than one plasmid, and 14 different profiles were found. No correlation was found\n         between species, antibiograms, plasmid profiles, or presence of class 1 integrons. Conjugation resulted in 25 transconjugants, which all were resistant to four or more antimicrobial agents and all harbored\n         at least one plasmid (&gt;60 kb). Class 1 integrons were detected in 64% of the transconjugants. Phenotypic resistance pattern and plasmid profiles of the transconjugants seemed independent of the presence\n         of an integron. Class 1 integrons seemed of less importance in phenotypic antibiograms and in transfer of resistance genes than conjugative plasmids.\n                  <\/jats:p>","DOI":"10.1089\/107662903322541856","type":"journal-article","created":{"date-parts":[[2003,11,10]],"date-time":"2003-11-10T17:05:49Z","timestamp":1068483949000},"page":"17-24","source":"Crossref","is-referenced-by-count":11,"title":["Characterization of Antimicrobial Resistance, Plasmids, and Gene Cassettes in\n                    <i>Shigella<\/i>\n                    spp. from Patients in Vietnam"],"prefix":"10.1177","volume":"9","author":[{"given":"J.","family":"Iversen","sequence":"first","affiliation":[{"name":"Department of Veterinary Microbiology, Royal Veterinary and Agricultural University, DK-1870 Frederiksberg C, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sandvang","sequence":"additional","affiliation":[{"name":"Statens Serum Institute, DK-2300 Copenhagen S, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Srijan","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, 10400 Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.D.","family":"Cam","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology, Hanoi, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dalsgaard","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology, Royal Veterinary and Agricultural University, DK-1870 Frederiksberg C, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,10]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/107662903322541856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/107662903322541856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:14:12Z","timestamp":1770747252000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/107662903322541856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":0,"journal-issue":{"issue":"1_suppl","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.1089\/107662903322541856"],"URL":"https:\/\/doi.org\/10.1089\/107662903322541856","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10]]}}}