{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T09:06:41Z","timestamp":1770800801210,"version":"3.50.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p>\n                    The increasing incidence of ciprofloxacin resistance in\n                    <jats:italic toggle=\"yes\">Streptococcus pneumoniae<\/jats:italic>\n                    may limit the efficacy of the new quinolones in difficult-to-treat infections such as meningitis. The aim of the present\n         study was to determine the efficacy of clinafloxacin alone and in combination with teicoplanin and rifampin in the therapy of ciprofloxacin-susceptible and ciprofloxacin-resistant pneumococcal meningitis\n         in rabbits. When used against a penicillin-resistant ciprofloxacin-susceptible strain (Clinafloxacin MIC 0.12\n                    <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>\n                    g\/ml), clinafloxacin at a dose of 20 mg\/kg per day b.i.d. decreased bacterial concentration\n         by -5.10 log cfu\/ml at 24 hr. Combinations did not improve activity. The same clinafloxacin schedule against a penicillin- and ciprofloxacin-resistant strain (Clinafloxacin MIC 0.5\n                    <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>\n                    g\/ml) was\n         totally ineffective. Our data suggest that a moderate decrease in quinolone susceptibility, as indicated by the detection of any degree of ciprofloxacin resistance, may render these antibiotics unsuitable\n         for the management of pneumococcal meningitis.\n                  <\/jats:p>","DOI":"10.1089\/107662903322541900","type":"journal-article","created":{"date-parts":[[2003,11,10]],"date-time":"2003-11-10T17:05:49Z","timestamp":1068483949000},"page":"53-59","source":"Crossref","is-referenced-by-count":4,"title":["Experimental Study of Clinafloxacin Alone and in Combination in the Treatment of Ciprofloxacin-Susceptible and -Resistant Pneumococcal Meningitis"],"prefix":"10.1177","volume":"9","author":[{"given":"A.","family":"Domenech","sequence":"first","affiliation":[{"name":"Experimental Infection Laboratory, Infectious Diseases Service and Microbiology Service, Hospital Universitari de Bellvitge, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cabellos","sequence":"additional","affiliation":[{"name":"Experimental Infection Laboratory, Infectious Diseases Service and Microbiology Service, Hospital Universitari de Bellvitge, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ribes","sequence":"additional","affiliation":[{"name":"Experimental Infection Laboratory, Infectious Diseases Service and Microbiology Service, Hospital Universitari de Bellvitge, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Tubau","sequence":"additional","affiliation":[{"name":"Experimental Infection Laboratory, Infectious Diseases Service and Microbiology Service, Hospital Universitari de Bellvitge, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.F.","family":"Viladrich","sequence":"additional","affiliation":[{"name":"Experimental Infection Laboratory, Infectious Diseases Service and Microbiology Service, Hospital Universitari de Bellvitge, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Li\u00f1ares","sequence":"additional","affiliation":[{"name":"Experimental Infection Laboratory, Infectious Diseases Service and Microbiology Service, Hospital Universitari de Bellvitge, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Gudiol","sequence":"additional","affiliation":[{"name":"Experimental Infection Laboratory, Infectious Diseases Service and Microbiology Service, Hospital Universitari de Bellvitge, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,10]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/107662903322541900","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/107662903322541900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:14:14Z","timestamp":1770747254000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/107662903322541900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":0,"journal-issue":{"issue":"1_suppl","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.1089\/107662903322541900"],"URL":"https:\/\/doi.org\/10.1089\/107662903322541900","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10]]}}}