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Additive manufacturing (AM) has an advantage in fabricating patient-specific and anatomical-shape-matching bone implants with controllable and well-designed porous architectures through tissue engineering. The sharp angles of strut joints in porous structures can cause stress concentration, reducing mechanical properties of the structures. In this study, porous Ta scaffolds comprising rhombic dodecahedron lattice unit cells with optimized node radius and porosities of 65%, 75%, and 85% were designed and fabricated by AM. The porous architecture and microstructure were characterized. The compressive behavior and failure mechanism of the material were explored through experimental compression tests and finite element analysis (FEA). Morphological evaluations revealed that the Ta scaffolds are fully interconnected, and the struts are dense. No processing defects and fractures were observed on the surface of struts. The scaffolds exhibited compressive yield strength of 5.8\u201332.3\u2009MPa and elastic modulus of 0.6\u20134.5 GPa, comparable to those of human cancellous and trabecular bone. The compressive stress\u2013strain curves of all samples show ductile deformation behavior accompanied by a smooth plateau region. The AM-fabricated rhombic dodecahedron lattice Ta scaffolds exhibited excellent ductility and mechanical reliability and plastic failure due to bending deformation under compressive loading. Deformation and factures primarily occurred at the junctions of the rhombus-arranged struts in the longitudinal section. Moreover, the struts in the middle of the scaffolds underwent a larger deformation than those close to the loading ends. FEA revealed a smooth stress distribution on the rhombic dodecahedron lattice structure with optimized node radius and stress concentration at the junctions of rhombus-arranged struts in the longitudinal section, which is in good agreement with the experimental results. Thus, the AM-fabricated Ta scaffolds with optimized node radius are promising alternatives for bone repair and regeneration.<\/jats:p>","DOI":"10.1089\/3dp.2021.0253","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T09:53:21Z","timestamp":1653472401000},"page":"887-904","source":"Crossref","is-referenced-by-count":7,"title":["Static Compressive Behavior and Failure Mechanism of Tantalum Scaffolds with Optimized Periodic Lattice Fabricated by Laser-Based Additive Manufacturing"],"prefix":"10.1177","volume":"10","author":[{"given":"Hairui","family":"Gao","sequence":"first","affiliation":[{"name":"School of Mechanical &amp; Automobile Engineering, Qingdao University of Technology, Qingdao, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhou","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Mechanical &amp; Automobile Engineering, Qingdao University of Technology, Qingdao, P.R. 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